The Journal of Immunology, Vol 141, Issue 10 3306-3312, Copyright © 1988 by American Association of Immunologists

ARTICLES

Bone marrow cells from allogeneic bone marrow chimeras inhibit the generation of cytotoxic lymphocyte responses against both donor and recipient cells

M Ogasawara, K Iwabuchi, RA Good and K Onoe
Institute of Immunological Science, Hokkaido University, Sapporo, Japan.

When added to a mixed lymphocyte culture, bone marrow cells suppress the generation of CTL activity against H-2 Ag shared by the BM cells and the stimulator cells. These cells have been referred to as veto cells and are thought to play a role in maintaining self-tolerance. We analyzed the H-2 specificity of the suppression expressed by the veto cells from H-2 incompatible bone marrow chimeras, because lymphocytes of such chimeras had been shown to be tolerant to both donor and recipient Ag when tested by CTL responses. We found that the bone marrow cells of such chimeras which were featured by non-T and non-B cell characteristics inhibited the generation of CTL directed against either donor or recipient Ag, but not against third-party Ag. These observations suggest that in allogeneic chimeras the veto or veto-like cells alter the inhibitory specificity exhibited in the recipient microenvironment and indicate that these cells are directly involved in the induction and maintenance of self-tolerance.

This article has been cited by other articles:

				S. Reich-Zeliger, E. Bachar-Lustig, J. Gan, and Y. Reisner Tolerance Induction by Veto CTLs in the TCR Transgenic 2C Mouse Model. I. Relative Reactivity of Different Veto Cells J. Immunol., December 1, 2004; 173(11): 6654 - 6659. [Abstract] [Full Text] [PDF]