| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 140, Issue 8 2625-2632, Copyright © 1988 by American Association of Immunologists
ARTICLES |
F Rousset, RW Malefijt, B Slierendregt, JP Aubry, JY Bonnefoy, T Defrance, J Banchereau and JE de Vries
UNICET, Laboratory for Immunological Research, Dardilly, France.
The effect of rIL-4 on the expression of low affinity receptor for the Fc part of IgE (Fc epsilon R2/CD23) and class II MHC antigens on Burkitt's lymphoma (BL) cell lines was investigated. Some of the BL lines contained low percentages of CD23 and HLA-DQ-positive cells, but virtually all cells expressed HLA-DR. IL-4 induced CD23 and class II MHC Ag expression on 7 of 9 BL. Optimal CD23 and class II MHC expression was observed after 48-72 h of incubation. Induction of CD23 and class II MHC Ag in the BL cell line BL2 by IL-4 was confirmed at the specific mRNA level. Significant activation of HLA-DQ mRNA was obtained after 6 h of incubation with IL-4 and gradually increased during prolonged incubation. Maximal induction of mRNA transcription occurred after 48 to 72 h. Optimal induction of HLA-DR and CD23 transcription in BL2 was also observed after 48 to 72 h. The induction of CD23 and class II MHC Ag seems to be specific for IL-4, because rIL- 1, rIL-2, rIFN-gamma, recombinant granulocyte-macrophage-CSF, and a commercial source of low m.w. B cell growth factor were ineffective. In addition, the expression of class I MHC Ag, the transferrin receptor, CD38, CD25, CD10, CD20, and CD21 were not affected by IL-4. Interestingly, IFN-gamma and PGE2 suppressed the IL-4-induced membrane expression of CD23 and class II MHC Ag in a dose-dependent way. IFN- gamma also blocked IL-4-induced CD23 mRNA transcription in BL2 completely, whereas PGE2 (10(-7) M) was partially inhibitory. The induction of CD23 and class II MHC Ag by IL-4 required intact protein synthesis as shown by its inhibition by cycloheximide. These results indicate that the induction of CD23 and class II MHC Ag by IL-4 is regulated in a coordinated way.
This article has been cited by other articles:
|
|
 |
|
  A. Inoue, T. Yasuda, T. Yamamoto, and Y. Yamanashi Dok-1 is a Positive Regulator of IL-4 Signalling and IgE Response J. Biochem., August 1, 2007; 142(2): 257 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Valineva, J. Yang, R. Palovuori, and O. Silvennoinen The Transcriptional Co-activator Protein p100 Recruits Histone Acetyltransferase Activity to STAT6 and Mediates Interaction between the CREB-binding Protein and STAT6 J. Biol. Chem., April 15, 2005; 280(15): 14989 - 14996. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Schroder, P. J. Hertzog, T. Ravasi, and D. A. Hume Interferon-{gamma}: an overview of signals, mechanisms and functions J. Leukoc. Biol., February 1, 2004; 75(2): 163 - 189. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ek, C.-M. Hogerkorp, M. Dictor, M. Ehinger, and C. A. K. Borrebaeck Mantle Cell Lymphomas Express a Distinct Genetic Signature Affecting Lymphocyte Trafficking and Growth Regulation as Compared with Subpopulations of Normal Human B Cells Cancer Res., August 1, 2002; 62(15): 4398 - 4405. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Schroder, P. Pavlidis, A. Arimura, D. Capece, and P. B. Rothman Cutting Edge: STAT6 Serves as a Positive and Negative Regulator of Gene Expression in IL-4-Stimulated B Lymphocytes J. Immunol., February 1, 2002; 168(3): 996 - 1000. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Y. Larbi, A. R. Allen, F. W. K. Tam, D. O. Haskard, R. R. Lobb, P. M. R. Silva, and S. Nourshargh VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration Blood, November 15, 2000; 96(10): 3601 - 3609. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Pesu, K. Takaluoma, S. Aittomaki, A. Lagerstedt, K. Saksela, P. E. Kovanen, and O. Silvennoinen Interleukin-4-induced transcriptional activation by Stat6 involves multiple serine/threonine kinase pathways and serine phosphorylation of Stat6 Blood, January 15, 2000; 95(2): 494 - 502. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Gupta, M. Jiang, A. Anthony, and A. B. Pernis Lineage-specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4 J. Exp. Med., December 20, 1999; 190(12): 1837 - 1848. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Goenka, J. Youn, L. M. Dzurek, U. Schindler, L.-y. Yu-Lee, and M. Boothby Paired Stat6 C-Terminal Transcription Activation Domains Required Both for Inhibition of an IFN-Responsive Promoter and Trans-Activation J. Immunol., November 1, 1999; 163(9): 4663 - 4672. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hunot, N. Dugas, B. Faucheux, A. Hartmann, M. Tardieu, P. Debre, Y. Agid, B. Dugas, and E. C. Hirsch Fcepsilon RII/CD23 Is Expressed in Parkinson's Disease and Induces, In Vitro, Production of Nitric Oxide and Tumor Necrosis Factor-alpha in Glial Cells J. Neurosci., May 1, 1999; 19(9): 3440 - 3447. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Profita, A. M. Vignola, A. Sala, A. Mirabella, L. Siena, E. Pace, G. Folco, and G. Bonsignore Interleukin-4 Enhances 15-Lipoxygenase Activity and Incorporation of 15(S)-HETE into Cellular Phospholipids in Cultured Pulmonary Epithelial Cells Am. J. Respir. Cell Mol. Biol., January 1, 1999; 20(1): 61 - 68. [Abstract] [Full Text]
|
|
|
|
 |
|
 W Reith, C Herrero-Sanchez, M Kobr, P Silacci, C Berte, E Barras, S Fey, and B Mach MHC class II regulatory factor RFX has a novel DNA-binding domain and a functionally independent dimerization domain. Genes & Dev., September 1, 1990; 4(9): 1528 - 1540. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
