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The Journal of Immunology, Vol 140, Issue 6 1895-1902, Copyright © 1988 by American Association of Immunologists
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W Lew, JJ Oppenheim and K Matsushima
Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21701.
The suppression of IL-1 production in human adherent PBMC by a glucocorticoid hormone was studied. From 10(-5) to 10(-8) M glucocorticoid hormone (prednisolone) inhibited both IL-1 alpha and IL- 1 beta production by LPS-stimulated adherent human PBMC in a dose- dependent fashion, as assayed by Western blotting of cell-associated IL- 1 and a thymocyte comitogenic bioassay. IL-1 alpha and -beta mRNA levels were concomitantly suppressed by glucocorticoid treatment, as determined by Northern blotting analysis. These data suggest that the suppression of IL-1 activity by glucocorticoids is consistently associated with decreased levels of IL-1 proteins and mRNA expression and therefore presumably regulated at the transcriptional level.
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