The Journal of Immunology, Vol 140, Issue 5 1555-1560, Copyright © 1988 by American Association of Immunologists

ARTICLES

Autocrine growth of CD4+ T cells. Differential effects of IL-1 on helper and inflammatory T cells

LA Greenbaum, JB Horowitz, A Woods, T Pasqualini, EP Reich and K Bottomly
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510.

The growth factor requirements of cloned lines representing two major subsets of CD4+ T cells were examined. The helper subset, which produces IL-4 as its autocrine growth factor, proliferates in response to IL-2 or to IL-4 in the presence of IL-1. The inflammatory subset, which produces IL-2 as its autocrine growth factor, proliferates in response to IL-2 and, in the presence of limiting amounts of IL-2, shows increased proliferation in the presence of IL-4. The inflammatory subset does not proliferate in response to IL-1 plus IL-4. This ability to respond to the combination of IL-1 plus IL-4 correlates with the presence of IL-1R on the cloned lines tested. These data suggest that IL-1 may play a controlling role in the clonal expansion of CD4+ T cells of different functional types. This, in turn, suggests means by which the immune response could be directed into humoral or cell- mediated responses.

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