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The Journal of Immunology, Vol 140, Issue 5 1421-1424, Copyright © 1988 by American Association of Immunologists

ARTICLES

Intrathymic differentiation and tolerance induction of lymphokine- secreting Lyt-2+ T helper cells

T Mizuochi and A Singer
Immunology Branch, National Cancer Institute, Bethesda, MD 20892.

The present study has assessed thymic influence on the differentiation and recognition specificity of developing Lyt-2+ lymphokine-secreting T cells, and compared it with those of developing Lyt-2+ CTL. It was demonstrated that development of Lyt-2+ lymphokine-secreting Th cells requires an intrathymic differentiation step, and that peripheral Lyt- 2+ lymphokine-secreting Th cells, unlike peripheral Lyt-2+ CTL, are profoundly tolerant to intrathymically expressed alloantigens. These data are interpreted as demonstrating that functionally distinct Lyt-2+ T cell populations are heterogeneous in their requirements for differentiation and/or activation.


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