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The Journal of Immunology, Vol 140, Issue 4 1236-1238, Copyright © 1988 by American Association of Immunologists

ARTICLES

Protein Rou. A human IgA hybrid

E Mihaesco, MC Gendron, N Congy and B Frangione
Laboratory of Immunochemistry and Immunopathology, Hopital Saint-Louis, Paris, France.

Protein Rou is a human IgA2 myeloma protein that carries the isoallotype marker n A2m(2). Partial amino acid sequence of its H chain (alpha) shows that the hinge region and the CH2 domain are homologous to alpha 2-chain and the CH1 and the CH3 domains homologous to alpha 1. Moreover, the CH1 domain contains the H-L disulfide bond identical to alpha 1. It is concluded that Rou H chain is a hybrid molecule caused by a recombination between alpha 1 and alpha 2 genes. The recombination event occurred between alpha 1-exon 1 and alpha 2-exon hinge and corresponds to position 222-223 of the alpha-chain.




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