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The Journal of Immunology, Vol 140, Issue 4 1139-1141, Copyright © 1988 by American Association of Immunologists

ARTICLES

Soluble IL-2 receptor levels in serum from blood donors seropositive for HIV

HE Prince, S Kleinman and AE Williams
American Red Cross Blood Services, Los Angeles/Orange Countries Region, CA 90006.

Serum levels of soluble IL-2R (sIL-2R) were measured in blood donors seropositive for HIV. Approximately one-half (53/101) of these seropositive donors exhibited increased serum sIL-2R levels compared with seronegative controls (n = 65). Further, a significant inverse correlation was observed between serum sIL-2R levels and CD4 cell levels in seropositive study participants. These findings suggest that increased serum sIL-2R levels in HIV infection may be linked to CD4 cell loss, and thus reflective of the stage of HIV-induced disease.




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