The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Folks, T. M.
Right arrow Articles by Fauci, A. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Folks, T. M.
Right arrow Articles by Fauci, A. S.

The Journal of Immunology, Vol 140, Issue 4 1117-1122, Copyright © 1988 by American Association of Immunologists

ARTICLES

Characterization of a promonocyte clone chronically infected with HIV and inducible by 13-phorbol-12-myristate acetate

TM Folks, J Justement, A Kinter, S Schnittman, J Orenstein, G Poli and AS Fauci
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

The present study has investigated the effect of PMA, an inducer of monocyte differentiation, on HIV expression in a chronically infected promonocyte clone. After acute HIV infection of U937 cells, clones that constitutively expressed varying levels of HIV were isolated by limiting dilution. One clone (U1) produced low levels of HIV but was found to increase its production 20-fold after PMA induction, as detected by reverse transcriptase or A capture. Further characterization of U1 indicated that PMA could induce cellular differentiation and maturation in the clone similar to that in uninfected U937 cells. In addition, functional studies revealed that superoxide anion production from the U1 clone was not different from that of uninfected U937 cells. Electron microscopic studies of U1 indicated that PMA induced endocytotic vesicles containing many HIV particles. These studies provide a model at the clonal level to 1) examine latency or chronicity of HIV infection in monocytes and 2) delineate the signals required for conversion to high level viral expression.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. F. Nold, C. A. Nold-Petry, G. B. Pott, J. A. Zepp, M. T. Saavedra, S.-H. Kim, and C. A. Dinarello
Endogenous IL-32 Controls Cytokine and HIV-1 Production
J. Immunol., July 1, 2008; 181(1): 557 - 565.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Klatt, Z. Zhang, P. Kalantari, P. A. Hankey, D. S. Gilmour, and A. J. Henderson
The Receptor Tyrosine Kinase RON Represses HIV-1 Transcription by Targeting RNA Polymerase II Processivity
J. Immunol., February 1, 2008; 180(3): 1670 - 1677.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. R. Patel, J. Zhu, S. D. Tachado, J. Zhang, Z. Wan, J. Saukkonen, and H. Koziel
HIV Impairs TNF-{alpha} Mediated Macrophage Apoptotic Response to Mycobacterium tuberculosis
J. Immunol., November 15, 2007; 179(10): 6973 - 6980.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
C. Elia, E. Cassol, N. Sidenius, F. Blasi, A. Castagna, G. Poli, and M. Alfano
Inhibition of HIV replication by the plasminogen activator is dependent on vitronectin-mediated cell adhesion
J. Leukoc. Biol., November 1, 2007; 82(5): 1212 - 1220.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
Z. Zhang, A. Klatt, A. J. Henderson, and D. S. Gilmour
Transcription termination factor Pcf11 limits the processivity of Pol II on an HIV provirus to repress gene expression
Genes & Dev., July 1, 2007; 21(13): 1609 - 1614.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Zhang, A. Klatt, D. S. Gilmour, and A. J. Henderson
Negative Elongation Factor NELF Represses Human Immunodeficiency Virus Transcription by Pausing the RNA Polymerase II Complex
J. Biol. Chem., June 8, 2007; 282(23): 16981 - 16988.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. M. Oguariri, T. W. Brann, and T. Imamichi
Hydroxyurea and Interleukin-6 Synergistically Reactivate HIV-1 Replication in a Latently Infected Promonocytic Cell Line via SP1/SP3 Transcription Factors
J. Biol. Chem., February 9, 2007; 282(6): 3594 - 3604.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
A. Brown, H. Zhang, P. Lopez, C. A. Pardo, and S. Gartner
In vitro modeling of the HIV-macrophage reservoir
J. Leukoc. Biol., November 1, 2006; 80(5): 1127 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
E. Cassol, M. Alfano, P. Biswas, and G. Poli
Monocyte-derived macrophages and myeloid cell lines as targets of HIV-1 replication and persistence
J. Leukoc. Biol., November 1, 2006; 80(5): 1018 - 1030.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
X. Wang, S. D. Douglas, J.-S. Peng, D.-J. Zhou, Q. Wan, and W.-Z. Ho
An in Vitro Model of Morphine Withdrawal Manifests the Enhancing Effect on Human Immunodeficiency Virus Infection of Human T Lymphocytes through the Induction of Substance P
Am. J. Pathol., November 1, 2006; 169(5): 1663 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Rizzi, M. P. Crippa, R. E. Jeeninga, B. Berkhout, F. Blasi, G. Poli, and M. Alfano
Pertussis Toxin B-Oligomer Suppresses IL-6 Induced HIV-1 and Chemokine Expression in Chronically Infected U1 Cells via Inhibition of Activator Protein 1
J. Immunol., January 15, 2006; 176(2): 999 - 1006.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Varin, A.-Z. Decrion, E. Sabbah, V. Quivy, J. Sire, C. Van Lint, B. P. Roques, B. B. Aggarwal, and G. Herbein
Synthetic Vpr Protein Activates Activator Protein-1, c-Jun N-terminal Kinase, and NF-{kappa}B and Stimulates HIV-1 Transcription in Promonocytic Cells and Primary Macrophages
J. Biol. Chem., December 30, 2005; 280(52): 42557 - 42567.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. D. Tachado, J. Zhang, J. Zhu, N. Patel, and H. Koziel
HIV Impairs TNF-{alpha} Release in Response to Toll-Like Receptor 4 Stimulation in Human Macrophages In Vitro
Am. J. Respir. Cell Mol. Biol., December 1, 2005; 33(6): 610 - 621.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Caselli, M. Galvan, E. Cassai, A. Caruso, L. Sighinolfi, and D. Di Luca
Human herpesvirus 8 enhances human immunodeficiency virus replication in acutely infected cells and induces reactivation in latently infected cells
Blood, October 15, 2005; 106(8): 2790 - 2797.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. Rogez-Kreuz, B. Maneglier, M. Martin, N. Dereuddre-Bosquet, J. Martal, D. Dormont, and P. Clayette
Involvement of IL-6 in the anti-human immunodeficiency virus activity of IFN-{tau} in human macrophages
Int. Immunol., August 1, 2005; 17(8): 1047 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
V. Krishnan and S. L. Zeichner
Host Cell Gene Expression during Human Immunodeficiency Virus Type 1 Latency and Reactivation and Effects of Targeting Genes That Are Differentially Expressed in Viral Latency
J. Virol., September 1, 2004; 78(17): 9458 - 9473.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
T. M. Hanley, H. L. B. Kiefer, A. C. Schnitzler, J. E. Marcello, and G. A. Viglianti
Retinoid-Dependent Restriction of Human Immunodeficiency Virus Type 1 Replication in Monocytes/Macrophages
J. Virol., March 15, 2004; 78(6): 2819 - 2830.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. Pinti, P. Biswas, L. Troiano, M. Nasi, R. Ferraresi, C. Mussini, J. Vecchiet, R. Esposito, R. Paganelli, and A. Cossarizza
Different Sensitivity to Apoptosis in Cells of Monocytic or Lymphocytic Origin Chronically Infected with Human Immunodeficiency Virus Type-1
Experimental Biology and Medicine, December 1, 2003; 228(11): 1346 - 1354.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
D. G. Brooks, P. A. Arlen, L. Gao, C. M. R. Kitchen, and J. A. Zack
Identification of T cell-signaling pathways that stimulate latent HIV in primary cells
PNAS, October 28, 2003; 100(22): 12955 - 12960.
[Abstract] [Full Text] [PDF]

Home page
 J Med MicrobiolHome page
M. Ghassemi, R. M. Novak, M. F. Khalili, and J. Zhou
Viable Mycobacterium avium is required for the majority of human immunodeficiency virus-induced upregulation in monocytoid cells
J. Med. Microbiol., October 1, 2003; 52(10): 877 - 882.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Varin, S. K. Manna, V. Quivy, A.-Z. Decrion, C. Van Lint, G. Herbein, and B. B. Aggarwal
Exogenous Nef Protein Activates NF-kappa B, AP-1, and c-Jun N-Terminal Kinase and Stimulates HIV Transcription in Promonocytic Cells. ROLE IN AIDS PATHOGENESIS
J. Biol. Chem., January 17, 2003; 278(4): 2219 - 2227.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Sonza, H. P. Mutimer, K. O'Brien, P. Ellery, J. L. Howard, J. H. Axelrod, N. J. Deacon, S. M. Crowe, and D. F. J. Purcell
Selectively Reduced tat mRNA Heralds the Decline in Productive Human Immunodeficiency Virus Type 1 Infection in Monocyte-Derived Macrophages
J. Virol., November 13, 2002; 76(24): 12611 - 12621.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
O. Kutsch, E. N. Benveniste, G. M. Shaw, and D. N. Levy
Direct and Quantitative Single-Cell Analysis of Human Immunodeficiency Virus Type 1 Reactivation from Latency
J. Virol., July 29, 2002; 76(17): 8776 - 8786.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. Alfano, N. Sidenius, B. Panzeri, F. Blasi, and G. Poli
Urokinase-urokinase receptor interaction mediates an inhibitory signal for HIV-1 replication
PNAS, June 25, 2002; 99(13): 8862 - 8867.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. M. Hayes, B. R. Lane, S. R. King, D. M. Markovitz, and M. J. Coffey
Peroxisome Proliferator-activated Receptor gamma Agonists Inhibit HIV-1 Replication in Macrophages by Transcriptional and Post-transcriptional Effects
J. Biol. Chem., May 3, 2002; 277(19): 16913 - 16919.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Alfano, G. Vallanti, P. Biswas, C. Bovolenta, E. Vicenzi, B. Mantelli, T. Pushkarsky, R. Rappuoli, A. Lazzarin, M. Bukrinsky, et al.
The Binding Subunit of Pertussis Toxin Inhibits HIV Replication in Human Macrophages and Virus Expression in Chronically Infected Promonocytic U1 Cells
J. Immunol., February 1, 2001; 166(3): 1863 - 1870.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
M. Martin, N. Serradji, N. Dereuddre-Bosquet, G. Le Pavec, G. Fichet, A. Lamouri, F. Heymans, J. J. Godfroid, P. Clayette, and D. Dormont
PMS-601, a New Platelet-Activating Factor Receptor Antagonist That Inhibits Human Immunodeficiency Virus Replication and Potentiates Zidovudine Activity in Macrophages
Antimicrob. Agents Chemother., November 1, 2000; 44(11): 3150 - 3154.
[Abstract] [Full Text]

Home page
 J. Leukoc. Biol.Home page
W. Barcellini, G. Colombo, L. La Maestra, G. Clerici, L. Garofalo, A. T. Brini, J. M. Lipton, and A. Catania
{alpha}-Melanocyte-stimulating hormone peptides inhibit HIV-1 expression in chronically infected promonocytic U1 cells and in acutely infected monocytes
J. Leukoc. Biol., November 1, 2000; 68(5): 693 - 699.
[Abstract] [Full Text]

Home page
 Antimicrob. Agents Chemother.Home page
M. Thornton, L. Barkley, J. C. Mason, and S. Shaunak
Anti-Kaposi's Sarcoma and Antiangiogenic Activities of Sulfated Dextrins
Antimicrob. Agents Chemother., October 1, 1999; 43(10): 2528 - 2533.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
X. Yang, Y. Chen, and D. Gabuzda
ERK MAP Kinase Links Cytokine Signals to Activation of Latent HIV-1 Infection by Stimulating a Cooperative Interaction of AP-1 and NF-kappa B
J. Biol. Chem., September 24, 1999; 274(39): 27981 - 27988.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. W. Dow, C. K. Mathiason, and E. A. Hoover
In Vivo Monocyte Tropism of Pathogenic Feline Immunodeficiency Viruses
J. Virol., August 1, 1999; 73(8): 6852 - 6861.
[Abstract] [Full Text]

Home page
 Infect. Immun.Home page
S. Meddows-Taylor, D. J. Martin, and C. T. Tiemessen
Dysregulated Production of Interleukin-8 in Individuals Infected with Human Immunodeficiency Virus Type 1 and Mycobacterium tuberculosis
Infect. Immun., March 1, 1999; 67(3): 1251 - 1260.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
J. A. Turpin, R. W. Buckheit Jr., D. Derse, M. Hollingshead, K. Williamson, C. Palamone, M. C. Osterling, S. A. Hill, L. Graham, C. A. Schaeffer, et al.
Inhibition of Acute-, Latent-, and Chronic-Phase Human Immunodeficiency Virus Type 1 (HIV-1) Replication by a Bistriazoloacridone Analog That Selectively Inhibits HIV-1 Transcription
Antimicrob. Agents Chemother., March 1, 1998; 42(3): 487 - 494.
[Abstract] [Full Text]

Home page
 J. Virol.Home page
S. Emiliani, W. Fischle, M. Ott, C. Van Lint, C. A. Amella, and E. Verdin
Mutations in the tat Gene Are Responsible for Human Immunodeficiency Virus Type 1 Postintegration Latency in the U1 Cell Line
J. Virol., February 1, 1998; 72(2): 1666 - 1670.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Biswas, F. Delfanti, S. Bernasconi, M. Mengozzi, M. Cota, N. Polentarutti, A. Mantovani, A. Lazzarin, S. Sozzani, and G. Poli
Interleukin-6 Induces Monocyte Chemotactic Protein-1 in Peripheral Blood Mononuclear Cells and in the U937 Cell Line
Blood, January 1, 1998; 91(1): 258 - 265.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Yang, M. O. Gold, D. N. Tang, D. E. Lewis, E. Aguilar-Cordova, A. P. Rice, and C. H. Herrmann
TAK, an HIV Tat-associated kinase, is a member of the cyclin-dependent family of protein kinases and is induced by activation of peripheral blood lymphocytes and differentiation of promonocytic cell lines
PNAS, November 11, 1997; 94(23): 12331 - 12336.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
C. Giovannangeli, S. Diviacco, V. Labrousse, S. Gryaznov, P. Charneau, and C. Helene
Accessibility of nuclear DNA to triplex-forming oligonucleotides: The integrated HIV-1 provirus as a target
PNAS, January 7, 1997; 94(1): 79 - 84.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
W. G. Rice, J. G. Supko, L. Malspeis, R. W. Buckheit Jr., D. Clanton, M. Bu, L. Graham, C. A. Schaeffer, J. A. Turpin, J. Domagala, et al.
Inhibitors of HIV Nucleocapsid Protein Zinc Fingers as Candidates for the Treatment of AIDS
Science, November 17, 1995; 270(5239): 1194 - 1197.
[Abstract] [PDF]

Home page
 J. Biol. Chem.Home page
S. Legrand-Poels, V. Bours, B. Piret, M. Pflaum, B. Epe, B. Rentier, and J. Piette
Transcription Factor NF-kappaB Is Activated by Photosensitization Generating Oxidative DNA Damages
J. Biol. Chem., March 24, 1995; 270(12): 6925 - 6934.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
M. Garcia-Blanco and B. Cullen
Molecular basis of latency in pathogenic human viruses
Science, November 8, 1991; 254(5033): 815 - 820.
[Abstract] [PDF]

Home page
 ScienceHome page
G Poli, J. Orenstein, A Kinter, T. Folks, and A. Fauci
Interferon-alpha but not AZT suppresses HIV expression in chronically infected cell lines
Science, May 5, 1989; 244(4904): 575 - 577.
[Abstract] [PDF]

Home page
 ScienceHome page
T. Folks, S. Kessler, J. Orenstein, J. Justement, E. Jaffe, and A. Fauci
Infection and replication of HIV-1 in purified progenitor cells of normal human bone marrow
Science, November 11, 1988; 242(4880): 919 - 922.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1988 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1988 by The American Association of Immunologists, Inc. All rights reserved.