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The Journal of Immunology, Vol 140, Issue 4 1076-1080, Copyright © 1988 by American Association of Immunologists

ARTICLES

IL-2-dependent proliferation of thymic accessory cells

B Rocha, A Lehuen and M Papiernik
Institut National de la Sante et de la Recherche Medicale U 25, Centre National de la Recherche Scientifique UA 122 Hopital Necker, Paris, France.

Phagocytic cells of the thymic reticulum are Ia-positive accessory cells continuously produced in long term thymic stroma cultures. We show in the present paper that phagocytic cells of the thymic reticulum have R for IL-2. They share this property with splenic accessory cells produced in vitro by the same technique but have the unique property of proliferating in the presence of rIL-2. This proliferation is not enhanced by Con-A, is not linked to a lymphoid contaminant, and is specifically inhibited by an anti-IL-2R mAb.


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