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The Journal of Immunology, Vol 140, Issue 12 4253-4255, Copyright © 1988 by American Association of Immunologists
ARTICLES |
F Kievits, WJ Boerenkamp and P Ivanyi
Central Laboratory, Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Sera of C57BL/6 mice contained lymphocytotoxic antibodies after injections with syngeneic lymphoblasts. The antibodies were directed against bovine beta 2-microglobulin, a component of the culture medium, and mimicked H-2-specific antibodies by a preferential recognition of target cells expressing certain H-2 Ag. This "polymorphic" reactivity pattern was due to a variable capacity of H-2 molecules associated with bovine beta 2-microglobulin.
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