| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 140, Issue 11 3801-3807, Copyright © 1988 by American Association of Immunologists
ARTICLES |
DV Serreze and EH Leiter
Jackson Laboratory, Bar Harbor, ME 04609.
Nonobese diabetic (NOD) is an inbred mouse strain susceptible to development of T cell-mediated autoimmune diabetes. The strain is characterized by high percentages of T lymphocytes in lymphoid organs. The syngeneic mixed lymphocyte reaction (SMLR), a T cell response to self MHC class II Ag, is reportedly involved in the generation of a number of immunoregulatory cells, including suppressor inducers. A severely depressed SMLR characteristic of certain other autoimmune strains was found in NOD but not in nonautoimmune SWR/Bm mice. Moreover, IL-2 produced by NOD T cells at day 6 in an SMLR was at least one hundredfold reduced compared with SWR, and NOD T cells harvested from an SMLR at day 6 were functionally defective when tested for ability to induce suppression of an allogeneic MLR. However, functionally competent suppressor T cells were generated in NOD splenic leukocyte cultures in response to Con A, and IL-2 release from these was equivalent to that released by Con A-stimulated SWR splenocytes. A deficiency in cytokine release was not limited to IL-2, because peritoneal exudate cells from NOD exhibited a greatly diminished sensitivity to LPS-stimulated IL-1 release in comparison to SWR mice. IL-2 supplementation both in vitro and in vivo restored the ability of NOD T cells to respond in a SMLR, with production of cells capable of inducing suppression. Like SMLR-activated T cells from untreated SWR controls, SMLR blasts from IL-2-treated NOD mice were enriched for the L3T4 phenotype. IL-1 supplementation in vitro resulted in partial restoration of T suppressor activation in a SMLR. The depressed SMLR exhibited by NOD mice was apparently a stimulator cell dysfunction, because NOD stimulator cells failed to activate T cells from (SWR x NOD)F1 mice, whereas stimulators from SWR or F1 mice were capable of doing so. Collectively, these results suggest a defect in suppressor cell activation rather than an absence of this immunoregulatory cell population.
This article has been cited by other articles:
|
|
 |
|
  S. D. Burke, H. Dong, A. D. Hazan, and B. A. Croy Aberrant Endometrial Features of Pregnancy in Diabetic NOD Mice Diabetes, December 1, 2007; 56(12): 2919 - 2926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S. Mohamood, M. L. Guler, Z. Xiao, D. Zheng, A. Hess, Y. Wang, H. Yagita, J. P. Schneck, and A. R. A. Hamad Protection from Autoimmune Diabetes and T-Cell Lymphoproliferation Induced by FasL Mutation Are Differentially Regulated and Can Be Uncoupled Pharmacologically Am. J. Pathol., July 1, 2007; 171(1): 97 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. V. Serreze, M. A. Osborne, Y.-G. Chen, H. D. Chapman, T. Pearson, M. A. Brehm, and D. L. Greiner Partial versus Full Allogeneic Hemopoietic Chimerization Is a Preferential Means to Inhibit Type 1 Diabetes as the Latter Induces Generalized Immunosuppression J. Immunol., November 15, 2006; 177(10): 6675 - 6684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Alard, J. N. Manirarora, S. A. Parnell, J. L. Hudkins, S. L. Clark, and M. M. Kosiewicz Deficiency in NOD Antigen-Presenting Cell Function May Be Responsible for Suboptimal CD4+CD25+ T-Cell-Mediated Regulation and Type 1 Diabetes Development in NOD Mice. Diabetes, July 1, 2006; 55(7): 2098 - 2105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-H. Lee, Y.-G. Chen, J. Chen, P. C. Reifsnyder, D. V. Serreze, M. Clare-Salzler, M. Rodriguez, C. Wasserfall, M. A. Atkinson, and E. H. Leiter Novel Leptin Receptor Mutation in NOD/LtJ Mice Suppresses Type 1 Diabetes Progression: II. Immunologic Analysis Diabetes, January 1, 2006; 55(1): 171 - 178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Steptoe, J. M. Ritchie, L. K. Jones, and L. C. Harrison Autoimmune Diabetes Is Suppressed by Transfer of Proinsulin-Encoding Gr-1+ Myeloid Progenitor Cells That Differentiate In Vivo Into Resting Dendritic Cells Diabetes, February 1, 2005; 54(2): 434 - 442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-G. Chen, C.-M. Choisy-Rossi, T. M. Holl, H. D. Chapman, G. S. Besra, S. A. Porcelli, D. J. Shaffer, D. Roopenian, S. B. Wilson, and D. V. Serreze Activated NKT Cells Inhibit Autoimmune Diabetes through Tolerogenic Recruitment of Dendritic Cells to Pancreatic Lymph Nodes J. Immunol., February 1, 2005; 174(3): 1196 - 1204. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fan, A. Longacre, F. Meng, V. Patel, K. Hsiao, J. S. Koh, and J. S. Levine Cytokine Dysregulation Induced by Apoptotic Cells Is a Shared Characteristic of Macrophages from Nonobese Diabetic and Systemic Lupus Erythematosus-Prone Mice J. Immunol., April 15, 2004; 172(8): 4834 - 4843. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Silveira, J. Dombrowsky, E. Johnson, H. D. Chapman, D. Nemazee, and D. V. Serreze B Cell Selection Defects Underlie the Development of Diabetogenic APCs in Nonobese Diabetic Mice J. Immunol., April 15, 2004; 172(8): 5086 - 5094. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pearson, T. G. Markees, D. V. Serreze, M. A. Pierce, M. P. Marron, L. S. Wicker, L. B. Peterson, L. D. Shultz, J. P. Mordes, A. A. Rossini, et al. Genetic Disassociation of Autoimmunity and Resistance to Costimulation Blockade-Induced Transplantation Tolerance in Nonobese Diabetic Mice J. Immunol., July 1, 2003; 171(1): 185 - 195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Serreze, M. A. Pierce, C. M. Post, H. D. Chapman, H. Savage, R. T. Bronson, P. B. Rothman, and G. A. Cox Paralytic Autoimmune Myositis Develops in Nonobese Diabetic Mice Made Th1 Cytokine-Deficient by Expression of an IFN-{gamma} Receptor {beta}-Chain Transgene J. Immunol., March 1, 2003; 170(5): 2742 - 2749. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. P. Berzins, E. S. Venanzi, C. Benoist, and D. Mathis T-Cell Compartments of Prediabetic NOD Mice Diabetes, February 1, 2003; 52(2): 327 - 334. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yang, M. Bao, and J.-W. Yoon Intrinsic Defects in the T-Cell Lineage Results in Natural Killer T-Cell Deficiency and the Development of Diabetes in the Nonobese Diabetic Mouse Diabetes, December 1, 2001; 50(12): 2691 - 2699. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Quinn, M. Melo, D. Ethell, and Eli. E. Sercarz Relative resistance to nasally induced tolerance in non-obese diabetic mice but not other I-Ag7-expressing mouse strains Int. Immunol., October 1, 2001; 13(10): 1321 - 1333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. T. C. Kreuwel, J. A. Biggs, I. M. Pilip, E. G. Pamer, D. Lo, and L. A. Sherman Defective CD8+ T Cell Peripheral Tolerance in Nonobese Diabetic Mice J. Immunol., July 15, 2001; 167(2): 1112 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. G. A. Delemarre, P. G. Hoogeveen, M. de Haan-Meulman, P. J. Simons, and H. A. Drexhage Homotypic cluster formation of dendritic cells, a close correlate of their state of maturation. Defects in the biobreeding diabetes-prone rat J. Leukoc. Biol., March 1, 2001; 69(3): 373 - 380. [Abstract] [Full Text]
|
|
|
|
|
|
D. V. Serreze, H. D. Chapman, C. M. Post, E. A. Johnson, W. L. Suarez-Pinzon, and A. Rabinovitch Th1 to Th2 Cytokine Shifts in Nonobese Diabetic Mice: Sometimes an Outcome, Rather Than the Cause, of Diabetes Resistance Elicited by Immunostimulation J. Immunol., January 15, 2001; 166(2): 1352 - 1359. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Trembleau, G. Penna, S. Gregori, G. Magistrelli, A. Isacchi, and L. Adorini Early Th1 Response in Unprimed Nonobese Diabetic Mice to the Tyrosine Phosphatase-Like Insulinoma-Associated Protein 2, an Autoantigen in Type 1 Diabetes J. Immunol., December 15, 2000; 165(12): 6748 - 6755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. G. A. Delemarre, P. J. Simons, H. J. de Heer, and H. A. Drexhage Signs of Immaturity of Splenic Dendritic Cells from the Autoimmune Prone Biobreeding Rat: Consequences for the In Vitro Expansion of Regulator and Effector T Cells J. Immunol., February 1, 1999; 162(3): 1795 - 1801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. V. Serreze, S. A. Fleming, H. D. Chapman, S. D. Richard, E. H. Leiter, and R. M. Tisch B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice J. Immunol., October 15, 1998; 161(8): 3912 - 3918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Takahashi, M. C. Honeyman, and L. C. Harrison Impaired Yield, Phenotype, and Function of Monocyte-Derived Dendritic Cells in Humans at Risk for Insulin-Dependent Diabetes J. Immunol., September 1, 1998; 161(5): 2629 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Greiner, R. A. Hesselton, and L. D. Shultz SCID Mouse Models of Human Stem Cell Engraftment Stem Cells, May 1, 1998; 16(3): 166 - 177. [Abstract] [Full Text]
|
|
|
|
|
|
D. V. Serreze, M. Bridgett, H. D. Chapman, E. Chen, S. D. Richard, and E. H. Leiter Subcongenic Analysis of the Idd13 Locus in NOD/Lt Mice: Evidence for Several Susceptibility Genes Including a Possible Diabetogenic Role for {beta}2-Microglobulin J. Immunol., February 1, 1998; 160(3): 1472 - 1478. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Casteels, C. Mathieu, M. Waer, D. Valckx, L. Overbergh, J. M. Laureys, and R. Bouillon Prevention of Type I Diabetes in Nonobese Diabetic Mice by Late Intervention with Nonhypercalcemic Analogs of 1,25-Dihydroxyvitamin D3 in Combination with a Short Induction Course of Cyclosporin A Endocrinology, January 1, 1998; 139(1): 95 - 102. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Prins, J. Todd, N. Rodrigues, S Ghosh, P. Hogarth, L. Wicker, E Gaffney, P. Podolin, P. Fischer, A Sirotina, et al. Linkage on chromosome 3 of autoimmune diabetes and defective Fc receptor for IgG in NOD mice Science, April 30, 1993; 260(5108): 695 - 698. [Abstract] [PDF]
|
|
|
|
|
|
D. Faustman, X. Li, H. Y. Lin, R. Huang, and J. Guo Response Science, June 26, 1992; 256(5065): 1830 - 1831. [PDF]
|
|
|
|
|
|
D Faustman, X. Li, H. Lin, Y. Fu, G Eisenbarth, J Avruch, and J Guo Linkage of faulty major histocompatibility complex class I to autoimmune diabetes Science, December 20, 1991; 254(5039): 1756 - 1761. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
