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The Journal of Immunology, Vol 140, Issue 11 3745-3750, Copyright © 1988 by American Association of Immunologists

ARTICLES

Antigen-presenting cells for Lyt-2+ cells. I. Stimulation of unprimed Lyt-2+ cells by H-2 different Thy-1-Ia- cells prepared from spleen and bone marrow

J Sprent and M Schaefer
Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

In agreement with previous studies on Ia- tumor cells, evidence is presented that primary MLR of purified Lyt-2+ T cells to class I alloantigens can be elicited by a minor population of Thy 1- Ia- cells present in normal spleen, bone marrow, and day-13 fetal liver; these cells are non-stimulatory for L3T4+ T cells. The data strengthen the view that primary responses of Lyt-2+ cells do not require the presence of Ia+ cells.


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C. Hauser, F. Zipprich, I. Leblond, S. Wirth, and A. W. Hugin
Protective Immunity from Naive CD8+ T Cells Activated In Vitro with MHC Class I Binding Immunogenic Peptides and IL-2 in the Absence of Specialized APCs
J. Immunol., July 1, 1999; 163(1): 330 - 336.
[Abstract] [Full Text] [PDF]


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