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The Journal of Immunology, Vol 139, Issue 6 1935-1938, Copyright © 1987 by American Association of Immunologists

ARTICLES

Induction of interleukin 2 receptor (TAC) by tumor necrosis factor in YT cells

JC Lee, A Truneh, MF Smith Jr and KY Tsang

The effect of human recombinant tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) on interleukin 2 receptor (IL-2R) expression on YT cells was examined. IL-2R expression was assessed by flow cytometric analysis with a monoclonal antibody to IL-2R (anti- TAC). TNF-alpha, like IL-1 beta, induced increased levels of IL-2R expression on YT cells with similar kinetics of induction. Maximum induction occurred at 20 to 30 hr. On a molar basis. TNF was less active than IL-1 beta. RNA isolated from TNF-alpha- or IL-1 beta- treated YT cells contained increased levels of IL-2R-specific mRNA as indicated by slot blot analysis by using an IL-2R-specific mRNA probe. Kinetic and IL-1 beta mRNA expression studies indicated that the TNF effect was a direct one. Because IL-2R expression is known to be associated with lymphocyte activation, the present results suggest that TNF-alpha may play a role in the regulation of immune responses.


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G. Crabtree
Contingent genetic regulatory events in T lymphocyte activation
Science, January 20, 1989; 243(4889): 355 - 361.
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