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The Journal of Immunology, Vol 138, Issue 9 2960-2963, Copyright © 1987 by American Association of Immunologists

ARTICLES

Brain microvascular smooth muscle expresses class II antigens

MN Hart, MM Waldschmidt, JM Hanley-Hyde, SA Moore, JD Kemp and RL Schelper

Mouse (BALB/c) splenic lymphocytes co-cultured in vitro with syngeneic brain-derived microvascular smooth muscle (SM) proliferate and become activated. After subsequent transfer of the activated lymphocytes to a syngeneic host, a vasculitis develops in the host. Investigation of the possible antigen-presenting properties of the cultured SM has resulted in the demonstration of class II (Ia) antigens on the SM. Fluorescence- activated cell sorter analysis has shown that an average of 31% of unstimulated SM cells in culture were positive when stained with an anti-IE of the appropriate haplotype (H2d), and an average of 20% were positive with an anti-IA of the H2d haplotype. Controls consisting of irrelevant antibodies of the same isotype, as well as an anti-IA of the H2s haplotype, were negative. In contrast, BALB/c-derived brain microvascular endothelial cells showed considerably less class II antigen expression (7% for both IA and IE).


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D. C. Baiu, B. Barger, M. Sandor, Z. Fabry, and M. N. Hart
Autoantibodies to Vascular Smooth Muscle Are Pathogenic for Vasculitis
Am. J. Pathol., June 1, 2005; 166(6): 1851 - 1860.
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