| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 138, Issue 9 2826-2830, Copyright © 1987 by American Association of Immunologists
ARTICLES |
FD Finkelman, CM Snapper, JD Mountz and IM Katona
The possibility that injection of mice with an affinity-purified goat antibody to mouse IgD (GaM delta) that stimulates polyclonal IgG1 secretion might also stimulate differentiation of B cells into IgE- secreting cells was suggested by the observation that such treatment induces T cells from those mice to secrete a lymphokine, B cell stimulatory factor 1 (BSF-1), that can stimulate both IgG1 and IgE secretion in vitro. Studies described in this paper show that injection of BALB/c mice with 200 to 3200 micrograms of GaM delta greatly increased the quantity of splenic epsilon chain-encoding mRNA, the number of spleen cells with cytoplasmic IgE, and the concentration of serum IgE 7 days after injection. Serum IgE levels obtained in these mice were approximately 100 times baseline levels and were comparable with those found in mice infected with the nematode parasite Nippostrongylus brasiliensis, but were approximately 2000-fold less than the peak serum IgG1 levels induced by GaM delta injection. Both IgE and IgG1 secretion in GaM delta injected mice were T dependent (blocked by anti-L3T4 antibody). These observations are consistent with the hypothesis that BSF-1 may play a role in the in vivo stimulation of IgE secretion and provide an easy to apply model for the investigation of in vivo regulation of IgE responses.
This article has been cited by other articles:
|
|
 |
|
  M. A. Brown IL-4 Production by T Cells: You Need a Little to Get a Lot J. Immunol., September 1, 2008; 181(5): 2941 - 2942. [Full Text] [PDF]
|
|
|
|
|
|
P. P. Ho, P. Fontoura, M. Platten, R. A. Sobel, J. J. DeVoss, L. Y. Lee, B. A. Kidd, B. H. Tomooka, J. Capers, A. Agrawal, et al. A Suppressive Oligodeoxynucleotide Enhances the Efficacy of Myelin Cocktail/IL-4-Tolerizing DNA Vaccination and Treats Autoimmune Disease J. Immunol., November 1, 2005; 175(9): 6226 - 6234. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Forssell, P. Sideras, C. Eriksson, M. Malm-Erjefalt, K. Rydell-Tormanen, P.-O. Ericsson, and J. S. Erjefalt Interleukin-2-Inducible T Cell Kinase Regulates Mast Cell Degranulation and Acute Allergic Responses Am. J. Respir. Cell Mol. Biol., June 1, 2005; 32(6): 511 - 520. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Kelly-Welch, H. Y. Wang, L.-M. Wang, J. H. Pierce, G. Jay, F. Finkelman, and A. D. Keegan Transgenic Expression of Insulin Receptor Substrate 2 in Murine B Cells Alters the Cell Density-Dependence of IgE Production In Vitro and Enhances IgE Production In Vivo J. Immunol., March 1, 2004; 172(5): 2803 - 2810. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Woo, L. A. Gildea, L. M. Tack, M. L. Miller, Z. Spicer, D. E. Millhorn, F. D. Finkelman, D. J. Hassett, and G. E. Shull In Vivo Evidence for Interferon-gamma -mediated Homeostatic Mechanisms in Small Intestine of the NHE3 Na+/H+ Exchanger Knockout Model of Congenital Diarrhea J. Biol. Chem., December 6, 2002; 277(50): 49036 - 49046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ozaki, R. Spolski, C. G. Feng, C.-F. Qi, J. Cheng, A. Sher, H. C. Morse III, C. Liu, P. L. Schwartzberg, and W. J. Leonard A Critical Role for IL-21 in Regulating Immunoglobulin Production Science, November 22, 2002; 298(5598): 1630 - 1634. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Morris, W. C. Gause, and F. D. Finkelman IL-4 Suppression of In Vivo T Cell Activation and Antibody Production J. Immunol., February 15, 2000; 164(4): 1734 - 1740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. D. Finkelman and S. C. Morris Development of an assay to measure in vivo cytokine production in the mouse Int. Immunol., November 1, 1999; 11(11): 1811 - 1818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Payet, E. C. Woodward, and D. H. Conrad Humoral Response Suppression Observed with CD23 Transgenics J. Immunol., July 1, 1999; 163(1): 217 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gurunathan, K. R. Irvine, C.-Y. Wu, J. I. Cohen, E. Thomas, C. Prussin, N. P. Restifo, and R. A. Seder CD40 Ligand/Trimer DNA Enhances Both Humoral and Cellular Immune Responses and Induces Protective Immunity to Infectious and Tumor Challenge J. Immunol., November 1, 1998; 161(9): 4563 - 4571. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Foucras, C. Coureau, L. Beijleveld, P. Druet, A. Saoudi, and J.-C. Guery {beta}2-Microglobulin-Dependent T Cells Are Not Necessary for Alloantigen-Induced Th2 Responses After Neonatal Induction of Lymphoid Chimerism in Mice J. Immunol., August 15, 1998; 161(4): 1751 - 1757. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Renjifo, S. Wolf, P.-P. Pastoret, H. Bazin, J. Urbain, O. Leo, and M. Moser Carrier-Induced, Hapten-Specific Suppression: A Problem of Antigen Presentation? J. Immunol., July 15, 1998; 161(2): 702 - 706. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Maecker, M.-S. Do, and S. Levy CD81 on B cells promotes interleukin 4 secretion and antibody production during T helper type 2 immune responses PNAS, March 3, 1998; 95(5): 2458 - 2462. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamaguchi, C. S. Lantz, H. C. Oettgen, I. M. Katona, T. Fleming, I. Miyajima, J.-P. Kinet, and S. J. Galli IgE Enhances Mouse Mast Cell Fcepsilon RI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions J. Exp. Med., February 17, 1997; 185(4): 663 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Yoshimoto, A. Bendelac, C. Watson, J. Hu-Li, and W. E. Paul Role of NK1.1+ T Cells in a TH2 Response and in Immunoglobulin E Production Science, December 15, 1995; 270(5243): 1845 - 1847. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
