| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 138, Issue 10 3120-3129, Copyright © 1987 by American Association of Immunologists
ARTICLES |
RC Budd, JC Cerottini, C Horvath, C Bron, T Pedrazzini, RC Howe and HR MacDonald
The Pgp-1 glycoprotein was identified on a minor (27%) subset of peripheral Lyt-2+ or L3T4+ T cells. In contrast, mature medullary-type thymocytes (Lyt-2+ L3T4-, Lyt-2- L3T4+) were nearly devoid of cells expressing detectable surface Pgp-1. The appearance of peripheral Pgp-1- T cells was found to be thymus dependent, as demonstrated by the diminished proportion of Pgp-1- T cells after thymectomy and their virtual absence in athymic nude mice. The subsequent acquisition of surface Pgp-1 was found to be a stable differentiation event occurring concomitantly with primary antigenic stimulation; selected Pgp-1- mature T cells from thymus or periphery acquired constitutive expression of Pgp-1 after stimulation in vitro with alloantigen or mitogens. These observations were extended by studies in vivo showing that immunization with various antigens augmented the percentage of Pgp- 1+ spleen cells within the Lyt-2+ subset. Furthermore, the frequencies of antigen-specific CTLp, after immunization by any of three different antigens tested, were greatly enriched in the Pgp-1+ compared with the Pgp-1- subpopulations. Peritoneal exudate Lyt-2+ cells, after a localized allograft rejection, demonstrated a particularly prominent Pgp-1+ subpopulation (78%) that contained virtually all the allospecific cytolytic activity. A model consistent with all of these data proposes that mature thymocytes lacking surface Pgp-1 upon emigration to the periphery acquire its expression at the time of primary antigenic stimulation. Hence, expression of Pgp-1 among peripheral T cells is an important differentiation marker for identifying antigen-stimulated memory T cells.
This article has been cited by other articles:
|
|
 |
|
  D. R. Kaufman, J. Liu, A. Carville, K. G. Mansfield, M. J. E. Havenga, J. Goudsmit, and D. H. Barouch Trafficking of Antigen-Specific CD8+ T Lymphocytes to Mucosal Surfaces following Intramuscular Vaccination J. Immunol., September 15, 2008; 181(6): 4188 - 4198. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Vrisekoop, I. den Braber, A. B. de Boer, A. F. C. Ruiter, M. T. Ackermans, S. N. van der Crabben, E. H. R. Schrijver, G. Spierenburg, H. P. Sauerwein, M. D. Hazenberg, et al. Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool PNAS, April 22, 2008; 105(16): 6115 - 6120. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dutt, D. Tseng, J. Ermann, T. I. George, Y. P. Liu, C. R. Davis, C. G. Fathman, and S. Strober Naive and Memory T Cells Induce Different Types of Graft-versus-Host Disease J. Immunol., November 15, 2007; 179(10): 6547 - 6554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Valujskikh and X. C. Li Frontiers in Nephrology: T Cell Memory as a Barrier to Transplant Tolerance J. Am. Soc. Nephrol., August 1, 2007; 18(8): 2252 - 2261. [Full Text] [PDF]
|
|
|
|
|
|
M. S. Russell, M. Iskandar, O. L. Mykytczuk, J. H. E. Nash, L. Krishnan, and S. Sad A Reduced Antigen Load In Vivo, Rather Than Weak Inflammation, Causes a Substantial Delay in CD8+ T Cell Priming against Mycobacterium bovis (Bacillus Calmette-Guerin) J. Immunol., July 1, 2007; 179(1): 211 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shi, S. Hao, T. Chan, and J. Xiang CD4+ T cells stimulate memory CD8+ T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion J. Leukoc. Biol., December 1, 2006; 80(6): 1354 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Burne-Taney, M. Liu, D. Ascon, R. R. Molls, L. Racusen, and H. Rabb Transfer of lymphocytes from mice with renal ischemia can induce albuminuria in naive mice: a possible mechanism linking early injury and progressive renal disease? Am J Physiol Renal Physiol, November 1, 2006; 291(5): F981 - F986. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wang, K. G. McDonald, J. S. McDonough, and R. D. Newberry Murine isolated lymphoid follicles contain follicular B lymphocytes with a mucosal phenotype Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G595 - G604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Dubois, T. A. Waldmann, and J. R. Muller ITK and IL-15 support two distinct subsets of CD8+ T cells PNAS, August 8, 2006; 103(32): 12075 - 12080. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Shi and J. Xiang CD4+ T cell-independent maintenance and expansion of memory CD8+ T cells derived from in vitro dendritic cell activation Int. Immunol., June 1, 2006; 18(6): 887 - 895. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Bianchi, S. Gasser, A. Trumpp, and H. R. MacDonald c-Myc acts downstream of IL-15 in the regulation of memory CD8 T-cell homeostasis Blood, May 15, 2006; 107(10): 3992 - 3999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M Strutt, J. Uzonna, K. K McKinstry, and P. A Bretscher Activation of thymic T cells by MHC alloantigen requires syngeneic, activated CD4+ T cells and B cells as APC Int. Immunol., May 1, 2006; 18(5): 719 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Lindell, T. A. Moore, R. A. McDonald, G. B. Toews, and G. B. Huffnagle Distinct Compartmentalization of CD4+ T-Cell Effector Function Versus Proliferative Capacity during Pulmonary Cryptococcosis Am. J. Pathol., March 1, 2006; 168(3): 847 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. A. Rouschop, J. J. T. H. Roelofs, A. T. Rowshani, J. C. Leemans, T. van der Poll, I. J. M. ten Berge, J. J. Weening, and S. Florquin Pre-transplant plasma and cellular levels of CD44 correlate with acute renal allograft rejection Nephrol. Dial. Transplant., October 1, 2005; 20(10): 2248 - 2254. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Parameswaran, R. Suresh, V. Bal, S. Rath, and A. George Lack of ICAM-1 on APCs during T Cell Priming Leads to Poor Generation of Central Memory Cells J. Immunol., August 15, 2005; 175(4): 2201 - 2211. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Sloma, M. J. Hansen, A. A. MacDougall, V. P. Van Keulen, R. B. Jenkins, and L. R. Pease A Class I Transgene Reveals Regulatory Events on Chromosome 1 Marking Peripheral T Cell Differentiation and Memory J. Immunol., June 15, 2005; 174(12): 7564 - 7572. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Parretta, G. Cassese, P. Barba, A. Santoni, J. Guardiola, and F. Di Rosa CD8 Cell Division Maintaining Cytotoxic Memory Occurs Predominantly in the Bone Marrow J. Immunol., June 15, 2005; 174(12): 7654 - 7664. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. van Faassen, M. Saldanha, D. Gilbertson, R. Dudani, L. Krishnan, and S. Sad Reducing the Stimulation of CD8+ T Cells during Infection with Intracellular Bacteria Promotes Differentiation Primarily into a Central (CD62LhighCD44high) Subset J. Immunol., May 1, 2005; 174(9): 5341 - 5350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Zielinski, S. N. Jacob, F. Bouzahzah, B. E. Ehrlich, and J. Craft Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation J. Immunol., April 15, 2005; 174(8): 5100 - 5109. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Afanasyeva, D. Georgakopoulos, D. F. Belardi, D. Bedja, D. Fairweather, Y. Wang, Z. Kaya, K. L. Gabrielson, E. R. Rodriguez, P. Caturegli, et al. Impaired up-regulation of CD25 on CD4+ T cells in IFN-{gamma} knockout mice is associated with progression of myocarditis to heart failure PNAS, January 4, 2005; 102(1): 180 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Publicover, E. Ramsburg, and J. K. Rose Characterization of Nonpathogenic, Live, Viral Vaccine Vectors Inducing Potent Cellular Immune Responses J. Virol., September 1, 2004; 78(17): 9317 - 9324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Szanto, I. Gal, A. Gonda, T. T. Glant, and K. Mikecz Expression of L-Selectin, but Not CD44, Is Required for Early Neutrophil Extravasation in Antigen-Induced Arthritis J. Immunol., June 1, 2004; 172(11): 6723 - 6734. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, G. Joe, J. Zhu, R. Carroll, B. Levine, E. Hexner, C. June, and S. G. Emerson Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity Blood, May 15, 2004; 103(10): 3970 - 3978. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Richards, S. L. Dalheimer, B. D. Ehst, T. L. Vanasek, M. K. Jenkins, M. I. Hertz, and D. L. Mueller Indirect Minor Histocompatibility Antigen Presentation by Allograft Recipient Cells in the Draining Lymph Node Leads to the Activation and Clonal Expansion of CD4+ T Cells That Cause Obliterative Airways Disease J. Immunol., March 15, 2004; 172(6): 3469 - 3479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. van Faassen, R. Dudani, L. Krishnan, and S. Sad Prolonged Antigen Presentation, APC-, and CD8+ T Cell Turnover during Mycobacterial Infection: Comparison with Listeria monocytogenes J. Immunol., March 15, 2004; 172(6): 3491 - 3500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Bischof, M. Hofmann, T. N. M. Schumacher, F. A. Vyth-Dreese, R. Weissert, H. Schild, A. M. Kruisbeek, and A. Melms Analysis of Autoreactive CD4 T Cells in Experimental Autoimmune Encephalomyelitis after Primary and Secondary Challenge Using MHC Class II Tetramers J. Immunol., March 1, 2004; 172(5): 2878 - 2884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Chapdelaine, D. K. Smith, J. A. Pedras-Vasconcelos, L. Krishnan, and S. Sad Increased CD8+ T Cell Memory to Concurrent Infection at the Expense of Increased Erosion of Pre-existing Memory: The Paradoxical Role of IL-15 J. Immunol., November 15, 2003; 171(10): 5454 - 5460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. G. Barin, M. Afanasyeva, M. V. Talor, N. R. Rose, C. L. Burek, and P. Caturegli Thyroid-Specific Expression of IFN-{gamma} Limits Experimental Autoimmune Thyroiditis by Suppressing Lymphocyte Activation in Cervical Lymph Nodes J. Immunol., June 1, 2003; 170(11): 5523 - 5529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. I. McFarland, S. A. Hansal, D. I. Morris, D. W. McVicar, P. E. Love, and A. S. Rosenberg Signaling through MHC in transgenic mice generates a population of memory phenotype cytolytic cells that lack TCR Blood, June 1, 2003; 101(11): 4520 - 4528. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. M. Kerksiek, A. Ploss, I. Leiner, D. H. Busch, and E. G. Pamer H2-M3-Restricted Memory T Cells: Persistence and Activation Without Expansion J. Immunol., February 15, 2003; 170(4): 1862 - 1869. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Aggarwal, N. Ghilardi, M.-H. Xie, F. J. de Sauvage, and A. L. Gurney Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17 J. Biol. Chem., January 10, 2003; 278(3): 1910 - 1914. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Haglund, I. Leiner, K. Kerksiek, L. Buonocore, E. Pamer, and J. K. Rose Robust Recall and Long-Term Memory T-Cell Responses Induced by Prime-Boost Regimens with Heterologous Live Viral Vectors Expressing Human Immunodeficiency Virus Type 1 Gag and Env Proteins J. Virol., June 27, 2002; 76(15): 7506 - 7517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Lucas, L. O. Atherly, and L. J. Berg The Absence of Itk Inhibits Positive Selection Without Changing Lineage Commitment J. Immunol., June 15, 2002; 168(12): 6142 - 6151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Arimura, H. Kato, U. Dianzani, T. Okamoto, S. Kamekura, D. Buonfiglio, T. Miyoshi-Akiyama, T. Uchiyama, and J. Yagi A co-stimulatory molecule on activated T cells, H4/ICOS, delivers specific signals in Th cells and regulates their responses Int. Immunol., June 1, 2002; 14(6): 555 - 566. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Lang, P. Nguyen, R. Peach, W. C. Gause, and C. S. Via In Vivo CD86 Blockade Inhibits CD4+ T Cell Activation, Whereas CD80 Blockade Potentiates CD8+ T Cell Activation and CTL Effector Function J. Immunol., April 15, 2002; 168(8): 3786 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Ramsey, O. Winqvist, L. Puhakka, M. Halonen, A. Moro, O. Kampe, P. Eskelin, M. Pelto-Huikko, and L. Peltonen Aire deficient mice develop multiple features of APECED phenotype and show altered immune response Hum. Mol. Genet., February 1, 2002; 11(4): 397 - 409. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Anderson and A. R. Means Defective Signaling in a Subpopulation of CD4+ T Cells in the Absence of Ca2+/Calmodulin-Dependent Protein Kinase IV Mol. Cell. Biol., January 1, 2002; 22(1): 23 - 29. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-W. Mittrucker, A. Kohler, and S. H. E. Kaufmann Characterization of the Murine T-Lymphocyte Response to Salmonella enterica Serovar Typhimurium Infection Infect. Immun., January 1, 2002; 70(1): 199 - 203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Evans, R. A. Prell, C. J. Thalhofer, A. A. Hurwitz, and A. D. Weinberg Engagement of OX40 Enhances Antigen-Specific CD4+ T Cell Mobilization/Memory Development and Humoral Immunity: Comparison of {alpha}OX-40 with {alpha}CTLA-4 J. Immunol., December 15, 2001; 167(12): 6804 - 6811. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Wang and T. Mosmann In Vivo Priming of CD4 T Cells that Produce Interleukin (IL)-2 but not IL-4 or Interferon (IFN)-{gamma}, and Can Subsequently Differentiate into IL-4- or IFN-{gamma}-secreting Cells J. Exp. Med., October 8, 2001; 194(8): 1069 - 1080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Adolfsson, B. T. Huber, and S. N. Meydani Vitamin E-Enhanced IL-2 Production in Old Mice: Naive But Not Memory T Cells Show Increased Cell Division Cycling and IL-2-Producing Capacity J. Immunol., October 1, 2001; 167(7): 3809 - 3817. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. V. Serbina and J. L. Flynn CD8+ T Cells Participate in the Memory Immune Response to Mycobacterium tuberculosis Infect. Immun., July 1, 2001; 69(7): 4320 - 4328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Snider and H. Liang Early Intestinal Th1 Inflammation and Mucosal T Cell Recruitment During Acute Graft-Versus-Host Reaction J. Immunol., May 15, 2001; 166(10): 5991 - 5999. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Geiselhart, C. A. Humphries, T. A. Gregorio, S. Mou, J. Subleski, and K. L. Komschlies IL-7 Administration Alters the CD4:CD8 Ratio, Increases T Cell Numbers, and Increases T Cell Function in the Absence of Activation J. Immunol., March 1, 2001; 166(5): 3019 - 3027. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Pasare, P. Mukherjee, A. Verhoef, P. Bansal, S. K. Mendiratta, A. George, J. R. Lamb, S. Rath, and V. Bal T cells in mice expressing a transgenic human TCR{beta} chain get positively selected but cannot be activated in the periphery by signaling through TCR Int. Immunol., January 1, 2001; 13(1): 53 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Cerasoli, G. Kelsoe, and M. Sarzotti CD4+Thy1- thymocytes with a Th-type 2 cytokine response Int. Immunol., January 1, 2001; 13(1): 75 - 83. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Watanabe, K. Ikuta, S. Fagarasan, S. Yazumi, T. Chiba, and T. Honjo Migration and Differentiation of Autoreactive B-1 Cells Induced by Activated {gamma}/{delta} T Cells in Antierythrocyte Immunoglobulin Transgenic Mice J. Exp. Med., November 27, 2000; 192(11): 1577 - 1586. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Eberl, P. Brawand, and H. R. MacDonald Selective Bystander Proliferation of Memory CD4+ and CD8+ T Cells Upon NK T or T Cell Activation J. Immunol., October 15, 2000; 165(8): 4305 - 4311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Ramirez and D. Mason Recirculatory and Sessile CD4+ T Lymphocytes Differ on CD45RC Expression J. Immunol., August 15, 2000; 165(4): 1816 - 1823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Andersen, D. Dempsey, R. Chervenak, and S. R. Jennings Expression of Intracellular IFN-{gamma} in HSV-1-Specific CD8+ T Cells Identifies Distinct Responding Subpopulations During the Primary Response to Infection J. Immunol., August 15, 2000; 165(4): 2101 - 2107. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Dalton, L. Haynes, C.-Q. Chu, S. L. Swain, and S. Wittmer Interferon {gamma} Eliminates Responding CD4 T Cells during Mycobacterial Infection by Inducing Apoptosis of Activated CD4 T Cells J. Exp. Med., July 3, 2000; 192(1): 117 - 122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-Q. Chu, S. Wittmer, and D. K. Dalton Failure to Suppress the Expansion of the Activated CD4 T Cell Population in Interferon {gamma}-deficient Mice Leads to Exacerbation of Experimental Autoimmune Encephalomyelitis J. Exp. Med., July 3, 2000; 192(1): 123 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gasser, P. Corthesy, F. Beerman, H. R. MacDonald, and M. Nabholz Constitutive Expression of a Chimeric Receptor That Delivers IL-2/IL-15 Signals Allows Antigen-Independent Proliferation of CD8+CD44high But Not Other T Cells J. Immunol., June 1, 2000; 164(11): 5659 - 5667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Maeurer, P. Trinder, G. Hommel, W. Walter, K. Freitag, D. Atkins, and S. Storkel Interleukin-7 or Interleukin-15 Enhances Survival of Mycobacterium tuberculosis-Infected Mice Infect. Immun., May 1, 2000; 68(5): 2962 - 2970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Aung and B. S. Graham IL-4 Diminishes Perforin-Mediated and Increases Fas Ligand-Mediated Cytotoxicity In Vivo J. Immunol., April 1, 2000; 164(7): 3487 - 3493. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. N. Lambrecht, R. A. Pauwels, and B. Fazekas de St. Groth Induction of Rapid T Cell Activation, Division, and Recirculation by Intratracheal Injection of Dendritic Cells in a TCR Transgenic Model J. Immunol., March 15, 2000; 164(6): 2937 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. T. M. Chan and M. J. Shlomchik Cutting Edge: B Cells Promote CD8+ T Cell Activation in MRL-Faslpr Mice Independently of MHC Class I Antigen Presentation J. Immunol., February 15, 2000; 164(4): 1658 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Andersen and B. Smedegaard CD4+ T-Cell Subsets That Mediate Immunological Memory to Mycobacterium tuberculosis Infection in Mice Infect. Immun., February 1, 2000; 68(2): 621 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. M. Jones, S. C. Cose, J. M. McNally, S. R. Jennings, W. R. Heath, and F. R. Carbone Diminished secondary CTL response in draining lymph nodes on cutaneous challenge with herpes simplex virus J. Gen. Virol., February 1, 2000; 81(2): 407 - 414. [Abstract] [Full Text]
|
|
|
|
|
|
M. K. Slifka and J. L. Whitton Activated and Memory CD8+ T Cells Can Be Distinguished by Their Cytokine Profiles and Phenotypic Markers J. Immunol., January 1, 2000; 164(1): 208 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Manjunath, P. Shankar, B. Stockton, P. D. Dubey, J. Lieberman, and U. H. von Andrian A transgenic mou |
