| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 138, Issue 1 37-44, Copyright © 1987 by American Association of Immunologists
ARTICLES |
I Athanassakis, RC Bleackley, V Paetkau, L Guilbert, PJ Barr and TG Wegmann
Evidence for maternal immune recognition of the fetus can be found during pregnancy, yet the conceptus remains unharmed. Indeed, in some cases immunizing the mother with cells sharing histocompatibility antigens with the fetus is beneficial to fetal survival. This could be due to the effect of maternally derived lymphokines on placental growth and function, according to the immunostimulation hypothesis. We demonstrate here that placental cells in culture proliferate upon the addition of T cell-derived lymphokines. The lymphokine activity has been separated from IL 2 and B cell growth factor, and copurified with IL 3 and granulocyte-macrophage colony-stimulating factor (CSF-GM). Recombinant CSF-GM and recombinant IL 3 showed a similar effect. The placental cells that proliferate in culture are of fetal origin and are characterized by strong adherence, phagocytosis, nonspecific esterase staining, and response to the macrophage-specific colony-stimulating factor CSF-1. In addition, treatment of pregnant females with anti- thymocyte serum as well as anti-Ly-2.1 monoclonal antibody, at gestational times before Ly-2 antigen appearance in the fetus, leads to a reduction of the proliferative and phagocytic capacity of day 12 placentae. These results clearly demonstrate that maternal T cells act upon fetally derived placental cells to improve their proliferative and phagocytic potential, and thus provide evidence for the immunostimulatory role of these cells during pregnancy.
This article has been cited by other articles:
|
|
 |
|
  J. S. Fitzgerald, T. G. Poehlmann, E. Schleussner, and U. R. Markert Trophoblast invasion: the role of intracellular cytokine signalling via signal transducer and activator of transcription 3 (STAT3) Hum. Reprod. Update, April 17, 2008; (2008) dmn010v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Arcuri, L. Buchwalder, P. Toti, M. Cintorino, P. Tosi, C. J. Lockwood, B. Rybalov, and F. Schatz Differential Regulation of Colony Stimulating Factor 1 and Macrophage Migration Inhibitory Factor Expression by Inflammatory Cytokines in Term Human Decidua: Implications for Macrophage Trafficking at the Fetal-Maternal Interface Biol Reprod, March 1, 2007; 76(3): 433 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Dosiou and L. C. Giudice Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunologic Perspectives Endocr. Rev., February 1, 2005; 26(1): 44 - 62. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Amarante-Paffaro, G S Queiroz, S T Correa, B Spira, and E Bevilacqua Phagocytosis as a potential mechanism for microbial defense of mouse placental trophoblast cells Reproduction, August 1, 2004; 128(2): 207 - 218. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Malamitsi-Puchner, A. Sarandakou, V. Papagianni, E. Protonotarious, J. Tziotis, and D. Botsis Concentrations of Soluble Fas in Maternal Serum and Amniotic Fluid During Uncomplicated Pregnancies Reproductive Sciences, April 1, 2003; 10(3): 158 - 160. [Abstract] [PDF]
|
|
|
|
|
|
K. Nagaoka, A. Sakai, H. Nojima, Y. Suda, Y. Yokomizo, K. Imakawa, S. Sakai, and R. K. Christenson A Chemokine, Interferon (IFN)-{gamma}-Inducible Protein 10 kDa, Is Stimulated by IFN-{tau} and Recruits Immune Cells in the Ovine Endometrium Biol Reprod, April 1, 2003; 68(4): 1413 - 1421. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamasaki, T. Sasho, H. Moriya, M. Kanno, M. Harada, N. Kamada, E. Shimizu, T. Nakayama, and M. Taniguchi Extrathymic Development of V{{alpha}}11 T Cells in Placenta During Pregnancy and Their Possible Physiological Role J. Immunol., June 15, 2001; 166(12): 7244 - 7249. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Makhseed, R. Raghupathy, F. Azizieh, R. Farhat, N. Hassan, and A. Bandar Circulating cytokines and CD30 in normal human pregnancy and recurrent spontaneous abortions Hum. Reprod., September 1, 2000; 15(9): 2011 - 2017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Emond, E. Asselin, M. A. Fortier, B. D. Murphy, and R. D. Lambert Interferon-Tau Stimulates Granulocyte-Macrophage Colony-Stimulating Factor Gene Expression in Bovine Lymphocytes and Endometrial Stromal Cells Biol Reprod, June 1, 2000; 62(6): 1728 - 1737. [Abstract] [Full Text]
|
|
|
|
|
|
K. Ejima, T. Koji, D. Tsuruta, H. Nanri, M. Kashimura, and M. Ikeda Induction of Apoptosis in Placentas of Pregnant Mice Exposedto Lipopolysaccharides: Possible Involvement of Fas/Fas Ligand System Biol Reprod, January 1, 2000; 62(1): 178 - 185. [Abstract] [Full Text]
|
|
|
|
|
|
I. T. Manyonda and M. Y. Choy Collagen Phagocytosis by Human Extravillous Trophoblast: Potential Role in Trophoblastic Invasion Reproductive Sciences, May 1, 1999; 6(3): 158 - 166. [Abstract] [PDF]
|
|
|
|
|
|
S.A. Robertson, C.T. Roberts, K.L. Farr, A.R. Dunn, and R.F. Seamark Fertility Impairment in Granulocyte-Macrophage Colony-Stimulating Factor-Deficient Mice Biol Reprod, February 1, 1999; 60(2): 251 - 261. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Rivera, S. M. Olister, X. Liu, J. H. Thompson, X. Zhang, K. Pennline, R. Azuero, D. A. Clark, and M. J. S. Miller Interleukin-10 attenuates experimental fetal growth restriction and demise FASEB J, February 1, 1998; 12(2): 189 - 197. [Abstract] [Full Text]
|
|
|
|
 |
|
 J. F. Seymour, G. J. Lieschke, D. Grail, C. Quilici, G. Hodgson, and A. R. Dunn Mice Lacking Both Granulocyte Colony-Stimulating Factor (CSF) and Granulocyte-Macrophage CSF Have Impaired Reproductive Capacity, Perturbed Neonatal Granulopoiesis, Lung Disease, Amyloidosis, and Reduced Long-Term Survival Blood, October 15, 1997; 90(8): 3037 - 3049. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
