The Journal of Immunology, Vol 137, Issue 6 1893-1896, Copyright © 1986 by American Association of Immunologists

ARTICLES

Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon

JS Pober, MA Gimbrone Jr, LA Lapierre, DL Mendrick, W Fiers, R Rothlein and TA Springer

We have used the quantitative binding of murine monoclonal antibodies to the surface of cultured human umbilical vein endothelial (HUVE) cells to study the responses of HUVE cells to three different immune mediators: interleukin 1 (IL 1), tumor necrosis factor (TNF), and immune interferon (IFN-gamma). Antibody H4/18, reactive with an endothelial cell-specific activation antigen, does not bind to unstimulated HUVE cells but shows rapidly and transiently inducible binding (peak 4 to 6 hr) to cells stimulated by IL 1 or TNF that declines to basal levels by 24 hr, even in the continued presence of mediator. Binding of H4/18 is unaffected by IFN-gamma. Antibody RR1/1, reactive with intercellular adhesion molecule 1, binds to unstimulated HUVE cells, but binding is rapidly increased (plateau 24 hr) after stimulation by IL 1 or TNF and slowly increased (over several days) by IFN-gamma. In contrast to H4/18 binding, the increase in RR1/1 binding is sustained in the continued presence of mediator. Antibody W6/32, reactive with HLA-A,B antigens, binds to unstimulated HUVE cells and shows gradually progressive increases (over several days) in binding upon treatment with IFN-gamma or TNF. These observations demonstrate that HUVE cells show distinct but overlapping patterns of antigenic modulation in response to three different lymphokines, and suggest that the "activation" of endothelial cells observed in situ may represent a complex integration of several lymphokine-mediated signals.

This article has been cited by other articles:

				N. E. Hastings, R. E. Feaver, M. Y. Lee, B. R. Wamhoff, and B. R. Blackman Human IL-8 Regulates Smooth Muscle Cell VCAM-1 Expression in Response to Endothelial Cells Exposed to Atheroprone Flow Arterioscler Thromb Vasc Biol, May 1, 2009; 29(5): 725 - 731. [Abstract] [Full Text] [PDF]

				F. Roche, J-M. Gaspoz, V. Pichot, M. Picard-Kossovsky, D. Maudoux, A. Garcin, S. Celle, E. Sforza, J. C. Barthelemy, and on behalf of the PROOF and SYNAPSE Study Groups Association between C-reactive protein and unrecognised sleep-disordered breathing in the elderly Eur. Respir. J., April 1, 2009; 33(4): 797 - 803. [Abstract] [Full Text] [PDF]

				J. D. Walker, C. L. Maier, and J. S. Pober Cytomegalovirus-Infected Human Endothelial Cells Can Stimulate Allogeneic CD4+ Memory T Cells by Releasing Antigenic Exosomes J. Immunol., February 1, 2009; 182(3): 1548 - 1559. [Abstract] [Full Text] [PDF]

				J. A Belperio and A. Ardehali Chemokines and Transplant Vasculopathy Circ. Res., August 29, 2008; 103(5): 454 - 466. [Abstract] [Full Text] [PDF]

				C. A. Reichel, M. Rehberg, P. Bihari, C. M. Moser, S. Linder, A. Khandoga, and F. Krombach Gelatinases mediate neutrophil recruitment in vivo: evidence for stimulus specificity and a critical role in collagen IV remodeling J. Leukoc. Biol., April 1, 2008; 83(4): 864 - 874. [Abstract] [Full Text] [PDF]

				A. Woodfin, C. A. Reichel, A. Khandoga, M. Corada, M.-B. Voisin, C. Scheiermann, D. O. Haskard, E. Dejana, F. Krombach, and S. Nourshargh JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration Blood, September 15, 2007; 110(6): 1848 - 1856. [Abstract] [Full Text] [PDF]

				J. D. van Buul, E. Kanters, and P. L. Hordijk Endothelial Signaling by Ig-Like Cell Adhesion Molecules Arterioscler Thromb Vasc Biol, September 1, 2007; 27(9): 1870 - 1876. [Abstract] [Full Text] [PDF]

				R. Goel, D. Swanlund, J. Coad, G. F. Paciotti, and J. C. Bischof TNF-{alpha}-based accentuation in cryoinjury--dose, delivery, and response Mol. Cancer Ther., July 1, 2007; 6(7): 2039 - 2047. [Abstract] [Full Text] [PDF]

				G. Tellides and J. S. Pober Interferon-{gamma} Axis in Graft Arteriosclerosis Circ. Res., March 16, 2007; 100(5): 622 - 632. [Abstract] [Full Text] [PDF]

				E. Simeoni, J. Dudler, S. Fleury, J. Li, M. Pagnotta, M. Pascual, L. K. von Segesser, and G. Vassalli Gene transfer of a soluble IL-1 type 2 receptor-Ig fusion protein improves cardiac allograft survival in rats Eur. J. Cardiothorac. Surg., February 1, 2007; 31(2): 222 - 228. [Abstract] [Full Text] [PDF]

				L. M. O'Brien, L. D. Serpero, R. Tauman, and D. Gozal Plasma adhesion molecules in children with sleep-disordered breathing. Chest, April 1, 2006; 129(4): 947 - 953. [Abstract] [Full Text] [PDF]

				M. A. Amin, C. S. Haas, K. Zhu, P. J. Mansfield, M. J. Kim, N. P. Lackowski, and A. E. Koch Migration inhibitory factor up-regulates vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 via Src, PI3 kinase, and NF{kappa}B Blood, March 15, 2006; 107(6): 2252 - 2261. [Abstract] [Full Text] [PDF]

				S.-Q. Wu and W. C. Aird Thrombin, TNF-{alpha}, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H873 - H885. [Abstract] [Full Text] [PDF]

				K. D. Puri, T. A. Doggett, C.-Y. Huang, J. Douangpanya, J. S. Hayflick, M. Turner, J. Penninger, and T. G. Diacovo The role of endothelial PI3K{gamma} activity in neutrophil trafficking Blood, July 1, 2005; 106(1): 150 - 157. [Abstract] [Full Text] [PDF]

				M. J. Sylte, C. J. Kuckleburg, T. J. Inzana, P. J. Bertics, and C. J. Czuprynski Stimulation of P2X receptors enhances lipooligosaccharide-mediated apoptosis of endothelial cells J. Leukoc. Biol., June 1, 2005; 77(6): 958 - 965. [Abstract] [Full Text] [PDF]

				G. P.A. Rice, H.-P. Hartung, and P. A. Calabresi Anti-{alpha}4 integrin therapy for multiple sclerosis: Mechanisms and rationale Neurology, April 26, 2005; 64(8): 1336 - 1342. [Abstract] [Full Text] [PDF]

				S.-H. Cho, L. A. Stanciu, S. T. Holgate, and S. L. Johnston Increased Interleukin-4, Interleukin-5, and Interferon-{gamma} in Airway CD4+ and CD8+ T Cells in Atopic Asthma Am. J. Respir. Crit. Care Med., February 1, 2005; 171(3): 224 - 230. [Abstract] [Full Text] [PDF]

				R. L. Yauch, E. E. Kadel III, C. Nicholas, S. Tetangco, and D. O. Clary Transcriptional-Based Screens for Pathway-Specific, High-Throughput Target Discovery in Endothelial Cells J Biomol Screen, December 1, 2004; 9(8): 704 - 711. [Abstract] [PDF]

				T. Simoncini, P. Mannella, L. Fornari, A. Caruso, M. Y. Willis, S. Garibaldi, C. Baldacci, and A. R. Genazzani Differential Signal Transduction of Progesterone and Medroxyprogesterone Acetate in Human Endothelial Cells Endocrinology, December 1, 2004; 145(12): 5745 - 5756. [Abstract] [Full Text] [PDF]

				T. Vincent, R. F. Pettersson, R. G. Crystal, and P. L. Leopold Cytokine-Mediated Downregulation of Coxsackievirus-Adenovirus Receptor in Endothelial Cells J. Virol., August 1, 2004; 78(15): 8047 - 8058. [Abstract] [Full Text] [PDF]

				K. A. Lindstedt, M. J. Leskinen, and P. T. Kovanen Proteolysis of the Pericellular Matrix: A Novel Element Determining Cell Survival and Death in the Pathogenesis of Plaque Erosion and Rupture Arterioscler Thromb Vasc Biol, August 1, 2004; 24(8): 1350 - 1358. [Abstract] [Full Text] [PDF]

				T. El-Sawy, M. Miura, and R. Fairchild Early T Cell Response to Allografts Occuring Prior to Alloantigen Priming Up-Regulates Innate-Mediated Inflammation and Graft Necrosis Am. J. Pathol., July 1, 2004; 165(1): 147 - 157. [Abstract] [Full Text] [PDF]

				N. ISOGAI, H. TANAKA, and S. ASAMURA Thrombosis and Altered expression of Intercellular Adhesion Molecule-1 (Icam-1) after Avulsion Injury in Rat Vessels J Hand Surg Eur Vol., June 1, 2004; 29(3): 228 - 232. [Abstract] [Full Text] [PDF]

				R. Tauman, A. Ivanenko, L. M. O'Brien, and D. Gozal Plasma C-Reactive Protein Levels Among Children With Sleep-Disordered Breathing Pediatrics, June 1, 2004; 113(6): e564 - e569. [Abstract] [Full Text]

				E. Hagi-Pavli, P. M. Farthing, and S. Kapas Stimulation of adhesion molecule expression in human endothelial cells (HUVEC) by adrenomedullin and corticotrophin Am J Physiol Cell Physiol, February 1, 2004; 286(2): C239 - C246. [Abstract] [Full Text]

				G. Asimakopoulos Invited commentary Ann. Thorac. Surg., August 1, 2003; 76(2): 458 - 458. [Full Text] [PDF]

				M. A. Carluccio, L. Siculella, M. A. Ancora, M. Massaro, E. Scoditti, C. Storelli, F. Visioli, A. Distante, and R. De Caterina Olive Oil and Red Wine Antioxidant Polyphenols Inhibit Endothelial Activation: Antiatherogenic Properties of Mediterranean Diet Phytochemicals Arterioscler Thromb Vasc Biol, April 1, 2003; 23(4): 622 - 629. [Abstract] [Full Text] [PDF]

				M. M. Burdick, J. M. McCaffery, Y. S. Kim, B. S. Bochner, and K. Konstantopoulos Colon carcinoma cell glycolipids, integrins, and other glycoproteins mediate adhesion to HUVECs under flow Am J Physiol Cell Physiol, April 1, 2003; 284(4): C977 - C987. [Abstract] [Full Text] [PDF]

				W.-C. Huang, J.-J. Chen, and C.-C. Chen c-Src-dependent Tyrosine Phosphorylation of IKKbeta Is Involved in Tumor Necrosis Factor-alpha -induced Intercellular Adhesion Molecule-1 Expression J. Biol. Chem., March 7, 2003; 278(11): 9944 - 9952. [Abstract] [Full Text] [PDF]

				M. Xia, W. H. Ling, J. Ma, D. D. Kitts, and J. Zawistowski Supplementation of Diets with the Black Rice Pigment Fraction Attenuates Atherosclerotic Plaque Formation in Apolipoprotein E Deficient Mice J. Nutr., March 1, 2003; 133(3): 744 - 751. [Abstract] [Full Text] [PDF]

				O. M. Tepper, R. D. Galiano, J. M. Capla, C. Kalka, P. J. Gagne, G. R. Jacobowitz, J. P. Levine, and G. C. Gurtner Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures Circulation, November 26, 2002; 106(22): 2781 - 2786. [Abstract] [Full Text] [PDF]

				R. Besch, C. Giovannangeli, C. Kammerbauer, and K. Degitz Specific Inhibition of ICAM-1 Expression Mediated by Gene Targeting with Triplex-forming Oligonucleotides J. Biol. Chem., August 30, 2002; 277(36): 32473 - 32479. [Abstract] [Full Text] [PDF]

				A. D. Pradhan, N. Rifai, and P. M. Ridker Soluble Intercellular Adhesion Molecule-1, Soluble Vascular Adhesion Molecule-1, and the Development of Symptomatic Peripheral Arterial Disease in Men Circulation, August 13, 2002; 106(7): 820 - 825. [Abstract] [Full Text] [PDF]

				A. A. Kulidjian, A. C. Issekutz, and T. B. Issekutz Differential role of E-selectin and P-selectin in T lymphocyte migration to cutaneous inflammatory reactions induced by cytokines Int. Immunol., July 1, 2002; 14(7): 751 - 760. [Abstract] [Full Text] [PDF]

				S. Sheikh, R. Parhar, and F. Al-Mohanna Rapid static adhesion of human naive neutrophil to naive xenoendothelium under physiologic flow is independent of Gal{alpha}1,3-gal structures J. Leukoc. Biol., June 1, 2002; 71(6): 932 - 940. [Abstract] [Full Text] [PDF]

				A. A. El-Solh, M. J. Mador, P. Sikka, R. S. Dhillon, D. Amsterdam, and B. J. B. Grant Adhesion Molecules in Patients With Coronary Artery Disease and Moderate-to-Severe Obstructive Sleep Apnea* Chest, May 1, 2002; 121(5): 1541 - 1547. [Abstract] [Full Text] [PDF]

				G Riemekasten, S Ziemer, T Haupl, C Melzer, K Loddenkemper, S Hauptmann, G R Burmester, and F Hiepe Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation Lupus, April 1, 2002; 11(4): 204 - 207. [Abstract] [PDF]

				F. McLaughlin, V. J. Ludbrook, J. Cox, I. von Carlowitz, S. Brown, and A. M. Randi Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation Blood, December 1, 2001; 98(12): 3332 - 3339. [Abstract] [Full Text] [PDF]

				J. Lou, R. Lucas, and G. E. Grau Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans Clin. Microbiol. Rev., October 1, 2001; 14(4): 810 - 820. [Abstract] [Full Text]

				A. E. Hak, H. A. P. Pols, C. D. A. Stehouwer, J. Meijer, A. J. Kiliaan, A. Hofman, M. M. B. Breteler, and J. C. M. Witteman Markers of Inflammation and Cellular Adhesion Molecules in Relation to Insulin Resistance in Nondiabetic Elderly: The Rotterdam Study J. Clin. Endocrinol. Metab., September 1, 2001; 86(9): 4398 - 4405. [Abstract] [Full Text] [PDF]

				K. Morita, M. Miura, D. R. Paolone, T. M. Engeman, A. Kapoor, D. G. Remick, and R. L. Fairchild Early Chemokine Cascades in Murine Cardiac Grafts Regulate T Cell Recruitment and Progression of Acute Allograft Rejection J. Immunol., September 1, 2001; 167(5): 2979 - 2984. [Abstract] [Full Text] [PDF]

				D. K. Bishop, S. C. Wood, E. J. Eichwald, and C. G. Orosz Immunobiology of Allograft Rejection in the Absence of IFN-{{gamma}}: CD8+ Effector Cells Develop Independently of CD4+ Cells and CD40-CD40 Ligand Interactions J. Immunol., March 1, 2001; 166(5): 3248 - 3255. [Abstract] [Full Text] [PDF]

				S. D. AARON, J. B. ANGEL, M. LUNAU, K. WRIGHT, C. FEX, N. LE SAUX, and R. E. DALES Granulocyte Inflammatory Markers and Airway Infection during Acute Exacerbation of Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., February 1, 2001; 163(2): 349 - 355. [Abstract] [Full Text]

				R. De Caterina, T. Bourcier, U. Laufs, V. La Fata, G. Lazzerini, A. S. Neish, P. Libby, and J. K. Liao Induction of Endothelial-Leukocyte Interaction by Interferon-{{gamma}} Requires Coactivation of Nuclear Factor-{{kappa}}B Arterioscler Thromb Vasc Biol, February 1, 2001; 21(2): 227 - 232. [Abstract] [Full Text] [PDF]

				A. Hill, S. Gompertz, and R. Stockley Factors influencing airway inflammation in chronic obstructive pulmonary disease Thorax, November 1, 2000; 55(11): 970 - 977. [Full Text]

				N. Xu, A. Rahman, R. D. Minshall, C. Tiruppathi, and A. B. Malik {beta}2-Integrin Blockade Driven by E-Selectin Promoter Prevents Neutrophil Sequestration and Lung Injury in Mice Circ. Res., August 4, 2000; 87(3): 254 - 260. [Abstract] [Full Text] [PDF]

				N. Mozaffarian, A. Casadevall, and J. W. Berman Inhibition of Human Endothelial Cell Chemokine Production by the Opportunistic Fungal Pathogen Cryptococcus neoformans J. Immunol., August 1, 2000; 165(3): 1541 - 1547. [Abstract] [Full Text] [PDF]

				T. Simoncini, S. Maffei, G. Basta, G. Barsacchi, A. R. Genazzani, J. K. Liao, and R. De Caterina Estrogens and Glucocorticoids Inhibit Endothelial Vascular Cell Adhesion Molecule-1 Expression by Different Transcriptional Mechanisms Circ. Res., July 7, 2000; 87(1): 19 - 25. [Abstract] [Full Text] [PDF]

				C. M. Woods, G. Neslund, E. Kornbrust, and S. F. Flaim Perflubron attenuates neutrophil adhesion to activated endothelial cells in vitro Am J Physiol Lung Cell Mol Physiol, May 1, 2000; 278(5): L1008 - L1017. [Abstract] [Full Text] [PDF]

				D. A. Fox Cytokine Blockade as a New Strategy to Treat Rheumatoid Arthritis: Inhibition of Tumor Necrosis Factor Arch Intern Med, February 28, 2000; 160(4): 437 - 444. [Abstract] [Full Text] [PDF]

				D. Zohlnhofer, K. Brand, K. Schipek, G. Pogatsa-Murray, A. Schomig, and F.-J. Neumann Adhesion of Monocyte Very Late Antigen-4 to Endothelial Vascular Cell Adhesion Molecule-1 Induces Interleukin-1{beta}-Dependent Expression of Interleukin-6 in Endothelial Cells Arterioscler Thromb Vasc Biol, February 1, 2000; 20(2): 353 - 359. [Abstract] [Full Text] [PDF]

				M. J. Giese, D. C. Shum, S. A. Rayner, B. J. Mondino, and J. A. Berliner Adhesion Molecule Expression in a Rat Model of Staphylococcus aureus Endophthalmitis Invest. Ophthalmol. Vis. Sci., January 1, 2000; 41(1): 145 - 153. [Abstract] [Full Text]

				Y. Furukawa, G. Becker, J. L. Stinn, K. Shimizu, P. Libby, and R. N. Mitchell Interleukin-10 (IL-10) Augments Allograft Arterial Disease : Paradoxical Effects of IL-10 in Vivo Am. J. Pathol., December 1, 1999; 155(6): 1929 - 1939. [Abstract] [Full Text] [PDF]

				P. De Cesaris, D. Starace, G. Starace, A. Filippini, M. Stefanini, and E. Ziparo Activation of Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway by Tumor Necrosis Factor alpha Leads to Intercellular Adhesion Molecule-1 Expression J. Biol. Chem., October 8, 1999; 274(41): 28978 - 28982. [Abstract] [Full Text] [PDF]

				S. J. Han, J. H. Kim, Y. J. Noh, H. S. Chang, C. S. Kim, K.-S. Kim, S. Y. Ki, C. S. Park, and I. Y. Chung Interleukin (IL)-5 Downregulates Tumor Necrosis Factor (TNF)-Induced Eotaxin Messenger RNA (mRNA) Expression in Eosinophils . Induction of Eotaxin mRNA by TNF and IL-5 in Eosinophils Am. J. Respir. Cell Mol. Biol., September 1, 1999; 21(3): 303 - 310. [Abstract] [Full Text]

				K F Chung and P J Barnes Cytokines in asthma Thorax, September 1, 1999; 54(9): 825 - 857. [Full Text]

				G. Barillari, C. Sgadari, C. Palladino, R. Gendelman, A. Caputo, C. B. Morris, B. C. Nair, P. Markham, A. Nel, M. Sturzl, et al. Inflammatory Cytokines Synergize with the HIV-1 Tat Protein to Promote Angiogenesis and Kaposi's Sarcoma Via Induction of Basic Fibroblast Growth Factor and the {alpha}v{beta}3 Integrin J. Immunol., August 15, 1999; 163(4): 1929 - 1935. [Abstract] [Full Text] [PDF]

				K. Unkelbach, A. Gardemann, M. Kostrzewa, M. Philipp, H. Tillmanns, and W. Haberbosch A New Promoter Polymorphism in the Gene of Lipopolysaccharide Receptor CD14 Is Associated With Expired Myocardial Infarction in Patients With Low Atherosclerotic Risk Profile Arterioscler Thromb Vasc Biol, April 1, 1999; 19(4): 932 - 938. [Abstract] [Full Text] [PDF]

				W. Luttmann, T. Matthiesen, H. Matthys, and J. C. Virchow Jr. Synergistic Effects of Interleukin-4 or Interleukin-13 and Tumor Necrosis Factor-alpha on Eosinophil Activation In Vitro Am. J. Respir. Cell Mol. Biol., March 1, 1999; 20(3): 474 - 480. [Abstract] [Full Text]

				A. T. Gewirtz, A. M. Siber, J. L. Madara, and B. A. McCormick Orchestration of Neutrophil Movement by Intestinal Epithelial Cells in Response to Salmonella typhimurium Can Be Uncoupled from Bacterial Internalization Infect. Immun., February 1, 1999; 67(2): 608 - 617. [Abstract] [Full Text] [PDF]

				M. A. Carluccio, M. Massaro, C. Bonfrate, L. Siculella, M. Maffia, G. Nicolardi, A. Distante, C. Storelli, and Raffaele De Caterina Oleic Acid Inhibits Endothelial Activation : A Direct Vascular Antiatherogenic Mechanism of a Nutritional Component in the Mediterranean Diet Arterioscler Thromb Vasc Biol, February 1, 1999; 19(2): 220 - 228. [Abstract] [Full Text] [PDF]

				J. F. McHale, O. A. Harari, D. Marshall, and D. O. Haskard Vascular Endothelial Cell Expression of ICAM-1 and VCAM-1 at the Onset of Eliciting Contact Hypersensitivity in Mice: Evidence for a Dominant Role of TNF-{alpha} J. Immunol., February 1, 1999; 162(3): 1648 - 1655. [Abstract] [Full Text] [PDF]

				F McLaughlin, V. Ludbrook, I Kola, C. Campbell, and A. Randi Characterisation of the tumour necrosis factor (TNF)-(alpha) response elements in the human ICAM-2 promoter J. Cell Sci., January 12, 1999; 112(24): 4695 - 4703. [Abstract] [PDF]

				P. J. Barnes, K. F. Chung, and C. P. Page Inflammatory Mediators of Asthma: An Update Pharmacol. Rev., December 1, 1998; 50(4): 515 - 596. [Abstract] [Full Text] [PDF]

				B. Liliensiek, M. Rocha, V. Umansky, A. Benner, J. Lin, R. Ziegler, P. P. Nawroth, and V. Schirrmacher Identification of Four Genes in Endothelial Cells Whose Expression Is Affected by Tumor Cells and Host Immune Status---A Study in Ex Vivo-Isolated Endothelial Cells Blood, November 1, 1998; 92(9): 3394 - 3404. [Abstract] [Full Text] [PDF]

				P. Lorenzon, E. Vecile, E. Nardon, E. Ferrero, J.M. Harlan, F. Tedesco, and A. Dobrina Endothelial Cell E- and P-Selectin and Vascular Cell Adhesion Molecule-1 Function as Signaling Receptors J. Cell Biol., September 7, 1998; 142(5): 1381 - 1391. [Abstract] [Full Text] [PDF]

				A. M. Kas-Deelen, M. C. Harmsen, E. F. de Maar, W. J. van Son, and T. H. The A Sensitive Method for Quantifying Cytomegalic Endothelial Cells in Peripheral Blood from Cytomegalovirus-Infected Patients Clin. Vaccine Immunol., September 1, 1998; 5(5): 622 - 626. [Abstract] [Full Text]

				B. A. McCormick, A. M. Siber, and A. T. Maurelli Requirement of the Shigella flexneri Virulence Plasmid in the Ability To Induce Trafficking of Neutrophils across Polarized Monolayers of the Intestinal Epithelium Infect. Immun., September 1, 1998; 66(9): 4237 - 4243. [Abstract] [Full Text] [PDF]

				D. T. Ashby, K.-A. Rye, M. A. Clay, M. A. Vadas, J. R. Gamble, and P. J. Barter Factors Influencing the Ability of HDL to Inhibit Expression of Vascular Cell Adhesion Molecule-1 in Endothelial Cells Arterioscler Thromb Vasc Biol, September 1, 1998; 18(9): 1450 - 1455. [Abstract] [Full Text] [PDF]

				S. Guerder, E. E. Eynon, and R. A. Flavell Autoimmunity Without Diabetes in Transgenic Mice Expressing {beta} Cell-Specific CD86, But Not CD80: Parameters that Trigger Progression to Diabetes J. Immunol., September 1, 1998; 161(5): 2128 - 2140. [Abstract] [Full Text] [PDF]

				S. J. Compton, J. A. Cairns, S. T. Holgate, and A. F. Walls The Role of Mast Cell Tryptase in Regulating Endothelial Cell Proliferation, Cytokine Release, and Adhesion Molecule Expression: Tryptase Induces Expression of mRNA for IL-1{beta} and IL-8 and Stimulates the Selective Release of IL-8 from Human Umbilical Vein Endothelial Cells J. Immunol., August 15, 1998; 161(4): 1939 - 1946. [Abstract] [Full Text] [PDF]

				M. Yoshida, B. E. Szente, J.-M. Kiely, A. Rosenzweig, and M. A. Gimbrone Jr. Phosphorylation of the Cytoplasmic Domain of E-Selectin Is Regulated During Leukocyte-Endothelial Adhesion J. Immunol., July 15, 1998; 161(2): 933 - 941. [Abstract] [Full Text] [PDF]

				R. Hayward, R. Scalia, B. Hopper, J. Z. Appel III, and A. M. Lefer Cellular mechanisms of heparinase III protection in rat traumatic shock Am J Physiol Heart Circ Physiol, July 1, 1998; 275(1): H23 - H30. [Abstract] [Full Text] [PDF]

				J. Lin, B. Liliensiek, M. Kanitz, U. Schimanski, H. Bohrer, R. Waldherr, E. Martin, G. Kauffmann, R. Ziegler, and P. P. Nawroth Molecular cloning of genes differentially regulated by TNF-{alpha} in bovine aortic endothelial cells, fibroblasts and smooth muscle cells Cardiovasc Res, June 1, 1998; 38(3): 802 - 813. [Abstract] [Full Text] [PDF]

				K. Blease, J. Seybold, I. M. Adcock, P. G. Hellewell, and A. Burke-Gaffney Interleukin-4 and Lipopolysaccharide Synergize to Induce Vascular Cell Adhesion Molecule-1 Expression in Human Lung Microvascular Endothelial Cells Am. J. Respir. Cell Mol. Biol., May 1, 1998; 18(5): 620 - 630. [Abstract] [Full Text]

				R. Kacimi, J. S. Karliner, F. Koudssi, and C. S. Long Expression and Regulation of Adhesion Molecules in Cardiac Cells by Cytokines : Response to Acute Hypoxia Circ. Res., March 23, 1998; 82(5): 576 - 586. [Abstract] [Full Text] [PDF]

				J. M. Miotla, M. M. Teixeira, and P. G. Hellewell Suppression of Acute Lung Injury in Mice by an Inhibitor of Phosphodiesterase Type 4  Am. J. Respir. Cell Mol. Biol., March 1, 1998; 18(3): 411 - 420. [Abstract] [Full Text]

				L. E. Cano, S. S. Kashino, C. Arruda, D. Andre, C. F. Xidieh, L. M. Singer-Vermes, C. A. C. Vaz, E. Burger, and V. L. G. Calich Protective Role of Gamma Interferon in Experimental Pulmonary Paracoccidioidomycosis Infect. Immun., February 1, 1998; 66(2): 800 - 806. [Abstract] [Full Text] [PDF]

				M Trojano, C Avolio, M Ruggieri, F De Robertis, F Giuliani, D Paolicelli, and P Livrea Soluble Intercellular Adhesion Molecule-1 (sICAM-1) in serum and cerebrospinal fluid of demyelinating diseases of the central and peripheral nervous system Multiple Sclerosis, February 1, 1998; 4(1): 39 - 44. [Abstract] [PDF]

				T. Yen, C. A. Harrison, J. M. Devery, S. Leong, S. E. Iismaa, T. Yoshimura, and C. L. Geczy Induction of the S100 Chemotactic Protein, CP-10, in Murine Microvascular Endothelial Cells by Proinflammatory Stimuli Blood, December 15, 1997; 90(12): 4812 - 4821. [Abstract] [Full Text] [PDF]

				M.-J. Sanz, A. Hartnell, P. Chisholm, C. Williams, D. Davies, V. B. Weg, M. Feldmann, M. A. Bolanowski, R. R. Lobb, and S. Nourshargh Tumor Necrosis Factor alpha -Induced Eosinophil Accumulation in Rat Skin Is Dependent on alpha 4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways Blood, November 15, 1997; 90(10): 4144 - 4152. [Abstract] [Full Text] [PDF]

				M. Litwin, K. Clark, L. Noack, J. Furze, M. Berndt, S. Albelda, M. Vadas, and J. Gamble Novel Cytokine-independent Induction of Endothelial Adhesion Molecules Regulated by Platelet/Endothelial Cell Adhesion Molecule (CD31) J. Cell Biol., October 6, 1997; 139(1): 219 - 228. [Abstract] [Full Text] [PDF]

				K. Iwaki, K. Ohashi, M. Ikeda, K. Tsujioka, F. Kajiya, and M. Kurimoto Decrease in the Amount of Focal Adhesion Kinase (p125FAK) in Interleukin-1beta -stimulated Human Umbilical Vein Endothelial Cells by Binding of Human Monocytic Cell Lines J. Biol. Chem., August 15, 1997; 272(33): 20665 - 20670. [Abstract] [Full Text] [PDF]

				L. L. L. Paxton, L.-J. Li, V. Secor, J. L. Duff, S. M. Naik, N. Shibagaki, and S. W. Caughman Flanking Sequences for the Human Intercellular Adhesion Molecule-1 NF-kappa B Response Element Are Necessary for Tumor Necrosis Factor alpha -Induced Gene Expression J. Biol. Chem., June 20, 1997; 272(25): 15928 - 15935. [Abstract] [Full Text] [PDF]

				F. Tedesco, M. Pausa, E. Nardon, M. Introna, A. Mantovani, and A. Dobrina The Cytolytically Inactive Terminal Complement Complex Activates Endothelial Cells to Express Adhesion Molecules and Tissue Factor Procoagulant Activity J. Exp. Med., May 5, 1997; 185(9): 1619 - 1628. [Abstract] [Full Text] [PDF]

				G. Sais, A. Vidaller, A. Jucgla, E. Condom, and J. Peyri Adhesion Molecule Expression and Endothelial Cell Activation in Cutaneous Leukocytoclastic Vasculitis: An Immunohistologic and Clinical Study in 42 Patients Arch Dermatol, April 1, 1997; 133(4): 443 - 450. [Abstract] [PDF]

				M. R. Adams, W. Jessup, D. Hailstones, and D. S. Celermajer L-Arginine Reduces Human Monocyte Adhesion to Vascular Endothelium and Endothelial Expression of Cell Adhesion Molecules Circulation, February 4, 1997; 95(3): 662 - 668. [Abstract] [Full Text]

				A. Duperray, L. R. Languino, J. Plescia, A. McDowall, N. Hogg, A. G. Craig, A. R. Berendt, and D. C. Altieri Molecular Identification of a Novel Fibrinogen Binding Site on the First Domain of ICAM-1 Regulating Leukocyte-Endothelium Bridging J. Biol. Chem., January 3, 1997; 272(1): 435 - 441. [Abstract] [Full Text] [PDF]

				H. Nakamura, T. Yamamura, S. Umemoto, S. Fukuta, T. Shioi, A. Matsumori, S. Sasayama, and M. Matsuzaki Autoimmune Response in Chronic Ongoing Myocarditis Demonstrated by Heterotopic Cardiac Transplantation in Mice Circulation, December 15, 1996; 94(12): 3348 - 3354. [Abstract] [Full Text]

				J. Galea, J. Armstrong, P. Gadsdon, H. Holden, S. E. Francis, and C. M. Holt Interleukin-1ß in Coronary Arteries of Patients With Ischemic Heart Disease Arterioscler Thromb Vasc Biol, August 1, 1996; 16(8): 1000 - 1006. [Abstract] [Full Text]

				M. Kaneko, J. Hayashi, I. Saito, and N. Miyasaka Probucol Downregulates E-Selectin Expression on Cultured Human Vascular Endothelial Cells Arterioscler Thromb Vasc Biol, August 1, 1996; 16(8): 1047 - 1051. [Abstract] [Full Text]

				S. Nystedt, V. Ramakrishnan, and J. Sundelin The Proteinase-activated Receptor 2Is Induced by Inflammatory Mediators in Human Endothelial Cells. COMPARISON WITH THE THROMBIN RECEPTOR J. Biol. Chem., June 21, 1996; 271(25): 14910 - 14915. [Abstract] [Full Text] [PDF]

				J. M Courtney, B. M Matata, H. Q Yin, A. Esposito, A. Mahiout, D. P Taggart, and G. Lowe The influence of biomaterials on inflammatory responses to cardiopulmonary bypass Perfusion, May 1, 1996; 11(3): 220 - 228. [PDF]

				A. Hackman, Y. Abe, W. Insull Jr, H. Pownall, L. Smith, K. Dunn, A. M. Gotto Jr, and C. M. Ballantyne Levels of Soluble Cell Adhesion Molecules in Patients With Dyslipidemia Circulation, April 1, 1996; 93(7): 1334 - 1338. [Abstract] [Full Text]

				H. Tanaka, G. Sukhova, D. Schwartz, and P. Libby Proliferating Arterial Smooth Muscle Cells After Balloon Injury Express TNF-{alpha} but Not Interleukin-1 or Basic Fibroblast Growth Factor Arterioscler Thromb Vasc Biol, January 1, 1996; 16(1): 12 - 18. [Abstract] [Full Text]

				P. W. Weerwind, J. G. Maessen, L. J. H. van Tits, R. K. Stad, E. J. Fransen, D. S. de Jong, and O. C. K. M. Penn INFLUENCE OF DURAFLO II HEPARIN-TREATED EXTRACORPOREAL CIRCUITS ON THE SYSTEMIC INFLAMMATORY RESPONSE IN PATIENTS HAVING CORONARY BYPASS J. Thorac. Cardiovasc. Surg., December 1, 1995; 110(6): 1633 - 1641. [Abstract] [Full Text]

				P. A. Kiener, B. M. Rankin, P. M. Davis, S. A. Yocum, G. A. Warr, and R. I. Grove Immune Complexes of LDL Induce Atherogenic Responses in Human Monocytic Cells Arterioscler Thromb Vasc Biol, July 1, 1995; 15(7): 990 - 999. [Abstract] [Full Text]

				H. C. Ledebur and T. P. Parks Transcriptional Regulation of the Intercellular Adhesion Molecule-1 Gene by Inflammatory Cytokines in Human Endothelial Cells J. Biol. Chem., January 13, 1995; 270(2): 933 - 943. [Abstract] [Full Text] [PDF]

				R. Neumann, H. Leonhartsberger, R. Knobler, and H. Honigsmann Immunohistochemistry of Port-wine Stains and Normal Skin With Endothelium-Specific Antibodies PAL-E, Anti--ICAM-1, Anti--ELAM-1, and Anti--Factor VIIIrAg Arch Dermatol, July 1, 1994; 130(7): 879 - 883. [Abstract] [PDF]

				P. M. Kilbridge, J. E. Mayer, J. W. Newburger, P. R. Hickey, A. Z. Walsh, and E. J. Neufeld Induction of intercellular adhesion molecule-1 and E-selectin mRNA in heart and skeletal muscle of pediatric patients undergoing cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1183 - 1192. [Abstract] [Full Text]