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The Journal of Immunology, Vol 137, Issue 6 1845-1849, Copyright © 1986 by American Association of Immunologists

ARTICLES

Immune response gene control of lymphocyte proliferation induced by acetylcholine receptor-specific helper factor derived from lymphocytes of myasthenic mice

P Christadoss, JM Lindstrom, N Talal, CR Duvic, A Kalantri and M Shenoy

The role of lymphokines secreted by acetylcholine receptor (AChR)- reactive lymphocytes in the regulation of an autoimmune response to AChR has not been studied in the human or murine model of myasthenia gravis. We investigated whether AChR-immune lymphocytes derived from mice with experimental autoimmune myasthenia gravis (EAMG) can produce an AChR-specific, genetically controlled soluble factor with biologic activity. AChR-reactive lymphocytes of mice with EAMG secreted an AChR- specific helper factor in vitro, which induced proliferation of AChR- immune but not Mycobacterium tuberculosis-immune lymphocytes. Recombinant, I-A mutant, and monoclonal anti-I-A antibody analyses suggest that AChR-specific helper factor-induced lymphocyte proliferation is controlled by an immune response gene at the I-A subregion of the murine major histocompatibility complex, and is mediated by the I-A molecule.




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