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The Journal of Immunology, Vol 137, Issue 4 1270-1274, Copyright © 1986 by American Association of Immunologists

ARTICLES

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1

R Rothlein, ML Dustin, SD Marlin and TA Springer

Homotypic adhesion by phorbol ester-stimulated lymphocytes requires LFA- 1 and Mg+2 and does not involve like-like interactions between LFA-1 molecules on adjacent cells. The latter finding suggested that a second molecule, distinct from LFA-1, also participates in LFA-1-dependent adhesion. The identification of such a molecule was the object of this investigation. After immunization with LFA-1-deficient EBV-transformed lymphoblastoid cells, a MAb was obtained that inhibits phorbol ester- stimulated aggregation of LFA-1+ EBV lines. This MAb defines a novel cell surface molecule, which is designated intercellular adhesion molecule 1 (ICAM-1). ICAM-1 is distinct from LFA-1 in both cell distribution and structure. In SDS-PAGE, ICAM-1 isolated from JY cells is a single chain of Mr = 90,000. As shown by MAb inhibition, ICAM-1 participates in phorbol ester-stimulated adhesion reactions of B lymphocyte and myeloid cell lines and T lymphocyte blasts. However, aggregation of one T lymphocyte cell line (SKW-3) was inhibited by LFA- 1 but not ICAM-1 MAb. It is proposed that ICAM-1 may be a ligand in many, but not all, LFA-1-dependent adhesion reactions.


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M. Takahashi, S. Kitagawa, J.-I. Masuyama, U. Ikeda, T. Kasahara, Y.-I. Takahashi, Y. Furukawa, S. Kano, and K. Shimada
Human Monocyte–Endothelial Cell Interaction Induces Synthesis of Granulocyte-Macrophage Colony-Stimulating Factor
Circulation, March 15, 1996; 93(6): 1185 - 1193.
[Abstract] [Full Text]

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 JDRHome page
K. Matsushita, A. Sugiyama, T. Uchiyama, H. Igarashi, H. Ohkuni, S. Nagaoka, S. Kotani, and H. Takada
Induction of Lymphocytes Cytotoxic to Oral Epithelial Cells by Streptococcus mitis Superantigen
Journal of Dental Research, March 1, 1996; 75(3): 927 - 934.
[Abstract] [PDF]

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 Circ. Res.Home page
D. Kling, J. Fingerle, J. M. Harlan, R. R. Lobb, and F. Lang
Mononuclear Leukocytes Invade Rabbit Arterial Intima During Thickening Formation via CD18- and VLA-4–Dependent Mechanisms and Stimulate Smooth Muscle Migration
Circ. Res., December 1, 1995; 77(6): 1121 - 1128.
[Abstract] [Full Text]

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 CirculationHome page
M. M.H. Marijianowski, M. van Laar, J. Bras, and A. E. Becker
Chronic Congestive Heart Failure Is Associated With a Phenotypic Shift of Intramyocardial Endothelial Cells
Circulation, September 15, 1995; 92(6): 1494 - 1498.
[Abstract] [Full Text]

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 Ann. Thorac. Surg.Home page
J. F. Seccombe and H. V. Schaff
Coronary Artery Endothelial Function After Myocardial Ischemia and Reperfusion
Ann. Thorac. Surg., September 1, 1995; 60(3): 778 - 788.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
C. Huang and T. A. Springer
A Binding Interface on the I Domain of Lymphocyte Function-associated Antigen-1 (LFA-1) Required for Specific Interaction with Intercellular Adhesion Molecule 1 (ICAM-1)
J. Biol. Chem., August 11, 1995; 270(32): 19008 - 19016.
[Abstract] [Full Text] [PDF]

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 StrokeHome page
R. L. Zhang, M. Chopp, N. Jiang, W. X. Tang, J. Prostak, A. M. Manning, and D. C. Anderson
Anti–Intercellular Adhesion Molecule–1 Antibody Reduces Ischemic Cell Damage After Transient But Not Permanent Middle Cerebral Artery Occlusion in the Wistar Rat
Stroke, August 1, 1995; 26(8): 1438 - 1443.
[Abstract] [Full Text]

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 Circ. Res.Home page
M. Takahashi, J.-I. Masuyama, U. Ikeda, T. Kasahara, S.-I. Kitagawa, Y.-I. Takahashi, K. Shimada, and S. Kano
Induction of Monocyte Chemoattractant Protein-1 Synthesis in Human Monocytes During Transendothelial Migration In Vitro
Circ. Res., May 1, 1995; 76(5): 750 - 757.
[Abstract] [Full Text]

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 J. Biol. Chem.Home page
M. Champe, B. W. McIntyre, and P. W. Berman
Monoclonal Antibodies That Block the Activity of Leukocyte Function-associated Antigen 1 Recognize Three Discrete Epitopes in the Inserted Domain of CD11a
J. Biol. Chem., January 20, 1995; 270(3): 1388 - 1394.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C. L. Holness, P. A. Bates, A. J. Littler, C. D. Buckley, A. McDowall, D. Bossy, N. Hogg, and D. L. Simmons
Analysis of the Binding Site on Intercellular Adhesion Molecule 3 for the Leukocyte Integrin Lymphocyte Function-associated Antigen 1
J. Biol. Chem., January 13, 1995; 270(2): 877 - 884.
[Abstract] [Full Text] [PDF]

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 CROBMHome page
J. M. Crawford and K. Watanabe
Cell Adhesion Molecules in Inflammation and Immunity: Relevance to Periodontal Diseases
Critical Reviews in Oral Biology & Medicine, January 1, 1994; 5(2): 91 - 123.
[Abstract] [Full Text] [PDF]

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 Arch DermatolHome page
A. Gilhar, E. Aizen, N. Ohana, and A. Etzioni
Vitiliginous vs Pigmented Skin Response to Intradermal Administration of Interferon Gamma
Arch Dermatol, May 1, 1993; 129(5): 600 - 604.
[Abstract] [PDF]

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 Arch Otolaryngol Head Neck SurgHome page
R. L. Scher, W. M. Koch, and W. J. Richtsmeier
Induction of the Intercellular Adhesion Molecule (ICAM-1) on Squamous Cell Carcinoma by Interferon Gamma
Arch Otolaryngol Head Neck Surg, April 1, 1993; 119(4): 432 - 438.
[Abstract] [PDF]

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 Arch OphthalmolHome page
S. M. Whitcup, C.-C. Chan, Q. Li, and R. B. Nussenblatt
Expression of Cell Adhesion Molecules in Posterior Uveitis
Arch Ophthalmol, May 1, 1992; 110(5): 662 - 666.
[Abstract] [PDF]

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 Arch DermatolHome page
R. S. Kalish
Recent Developments in the Pathogenesis of Allergic Contact Dermatitis
Arch Dermatol, October 1, 1991; 127(10): 1558 - 1563.
[Abstract] [PDF]

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 VASC ENDOVASCULAR SURGHome page
R. Fasol, P. Zilla, P. Preiss, U. von Oppell, J. Odell, and B. Reichart
Allogenic, Multidonor In Vitro Endothelialization of Small Diameter PTFE Grafts in Baboons
Vascular and Endovascular Surgery, January 1, 1991; 25(1): 64 - 71.
[Abstract] [PDF]

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 ScienceHome page
A. Freedman, J. Munro, G. Rice, M. Bevilacqua, C Morimoto, B. McIntyre, K Rhynhart, J. Pober, and L. Nadler
Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110
Science, August 31, 1990; 249(4972): 1030 - 1033.
[Abstract] [PDF]

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 ScienceHome page
C. Wegner, R. Gundel, P Reilly, N Haynes, L. Letts, and R Rothlein
Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma
Science, January 26, 1990; 247(4941): 456 - 459.
[Abstract] [PDF]

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 ScienceHome page
G. Rice and M. Bevilacqua
An inducible endothelial cell surface glycoprotein mediates melanoma adhesion
Science, December 8, 1989; 246(4935): 1303 - 1306.
[Abstract] [PDF]

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 Cold Spring Harb Symp Quant BiolHome page
M.E.F. Smith, J.G. Bodmer, A.P. Kelly, J. Trowsdale, S.C. Kirkland, and W.F. Bodmer
Variation in HLA Expression on Tumors: An Escape from Immune Response
Cold Spring Harb Symp Quant Biol, January 1, 1989; 54(0): 581 - 586.
[Abstract] [PDF]

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 Cold Spring Harb Symp Quant BiolHome page
M.L. Dustin, J. Garcia-Aguilar, M.L. Hibbs, R.S. Larson, S.A. Stacker, D.E. Staunton, A.J. Wardlaw, and T.A. Springer
Structure and Regulation of the Leukocyte Adhesion Receptor LFA-1 and Its Counterreceptors, ICAM-1 and ICAM-2
Cold Spring Harb Symp Quant Biol, January 1, 1989; 54(0): 753 - 765.
[Abstract] [PDF]

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 ScienceHome page
J. Gamble and M. Vadas
Endothelial adhesiveness for blood neutrophils is inhibited by transforming growth factor-beta
Science, October 7, 1988; 242(4875): 97 - 99.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
C. Huang, Q. Zang, J. Takagi, and T. A. Springer
Structural and Functional Studies with Antibodies to the Integrin beta 2 Subunit. A MODEL FOR THE I-LIKE DOMAIN
J. Biol. Chem., July 7, 2000; 275(28): 21514 - 21524.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Roy, M. Audette, and M. J. Tremblay
Intercellular Adhesion Molecule-1 (ICAM-1) Gene Expression in Human T Cells Is Regulated by Phosphotyrosyl Phosphatase Activity. INVOLVEMENT OF NF-kappa B, Ets, AND PALINDROMIC INTERFERON-gamma -RESPONSIVE ELEMENT-BINDING SITES
J. Biol. Chem., April 27, 2001; 276(18): 14553 - 14561.
[Abstract] [Full Text] [PDF]


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