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The Journal of Immunology, Vol 137, Issue 3 948-951, Copyright © 1986 by American Association of Immunologists

ARTICLES

E alpha u and E beta u chain association: where lies the anomaly?

M Ayane, L Mengle-Gaw, HO McDevitt, C Benoist and D Mathis

H-2u haplotype mice are unique among all E alpha+ strains because they do not provide in heterozygotes an E alpha chain that interacts with E betak,s,etc. sufficiently well to allow certain E-restricted immune responses. As a first step in understanding this peculiarity, we have sequenced E alpha u and E beta u cDNA and compared the derived amino acid sequences with those of previously analyzed alleles. Although no glaring structural abnormalities were found, we have identified some u- specific residues and suggest which are the most likely to provoke a pairing anomaly.


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