The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shastri, N.
Right arrow Articles by Sercarz, E. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shastri, N.
Right arrow Articles by Sercarz, E. E.

The Journal of Immunology, Vol 137, Issue 3 911-915, Copyright © 1986 by American Association of Immunologists

ARTICLES

The choice between two distinct T cell determinants within a 23-amino acid region of lysozyme depends on their structural context

N Shastri, G Gammon, S Horvath, A Miller and EE Sercarz

The specificity of C57BL/6 T cells reactive to peptide aa 74-96 of hen egg-white lysozyme (HEL) was analyzed by using a panel of synthetic peptides of varying lengths from this region. It was found that peptide 74-96-reactive T cells induced by native HEL (aa 1-129) or its denatured fragment L2 (aa 13-105) recognized two distinct but overlapping determinants contained within aa 74-90 or aa 81-96, respectively. Peptide 74-96 itself induced both peptide 74-90-and peptide 81-96-specific T cells. Thus, a choice was made between these two potential T cell determinants on peptide 74-96, depending on which immunogen was used. Interestingly, the ability of both peptide determinants aa 74-90 and aa 81-96 to stimulate peptide 74-96-reactive T cells was partly dependent on the presence of residues within the overlap region (aa 81-90), suggesting that this region may play an important role in Iab-restricted T cell activation. This was further supported by the poor immunogenicity of shorter peptides 74-86 or 85- 96, lacking residues from the overlap region in B6 mice. These two short peptides were nevertheless capable of eliciting T cell responses in B10.A mice, suggesting that the importance of this overlap region in obtaining a response to peptide 74-96 is related to the MHC haplotype.


This article has been cited by other articles:


Home page
 CVIHome page
R. Sealy, W. Chaka, S. Surman, S. A. Brown, P. Cresswell, and J. L. Hurwitz
Target Peptide Sequence within Infectious Human Immunodeficiency Virus Type 1 Does Not Ensure Envelope-Specific T-Helper Cell Reactivation: Influences of Cysteine Protease and Gamma Interferon-Induced Thiol Reductase Activities
Clin. Vaccine Immunol., April 1, 2008; 15(4): 713 - 719.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Q. Lou, R. J. Kelleher Jr, A. Sette, J. Loyall, S. Southwood, R. B. Bankert, and S. H. Bernstein
Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells
Blood, August 1, 2004; 104(3): 752 - 759.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
V. Paharkova-Vatchkova, R. Maldonado, and S. Kovats
Estrogen Preferentially Promotes the Differentiation of CD11c+ CD11bintermediate Dendritic Cells from Bone Marrow Precursors
J. Immunol., February 1, 2004; 172(3): 1426 - 1436.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Li, M. A. Haque, and J. S. Blum
Role of Disulfide Bonds in Regulating Antigen Processing and Epitope Selection
J. Immunol., September 1, 2002; 169(5): 2444 - 2450.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. A. Haque, P. Li, S. K. Jackson, H. M. Zarour, J. W. Hawes, U. T. Phan, M. Maric, P. Cresswell, and J. S. Blum
Absence of {gamma}-Interferon-inducible Lysosomal Thiol Reductase in Melanomas Disrupts T Cell Recognition of Select Immunodominant Epitopes
J. Exp. Med., May 20, 2002; 195(10): 1267 - 1277.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H.-K. Kang, J. A. Mikszta23, H. Deng, E. E. Sercarz, P. E. Jensen, and B. S. Kim
Processing and Reactivity of T Cell Epitopes Containing Two Cysteine Residues from Hen Egg-White Lysozyme (HEL74-90)
J. Immunol., February 15, 2000; 164(4): 1775 - 1782.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Ma, P. E. Whiteley, P. M. Cameron, D. C. Freed, A. Pressey, S.-L. Chen, B. Garni-Wagner, C. Fang, D. M. Zaller, L. S. Wicker, et al.
Role of APC in the Selection of Immunodominant T Cell Epitopes
J. Immunol., December 15, 1999; 163(12): 6413 - 6423.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. D. Moudgil, S. Southwood, A. Ametani, K. Kim, A. Sette, and E. E. Sercarz
The Self-Directed T Cell Repertoire Against Mouse Lysozyme Reflects the Influence of the Hierarchy of Its Own Determinants and Can Be Engaged by a Foreign Lysozyme
J. Immunol., October 15, 1999; 163(8): 4232 - 4237.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
B. Arunachalam, M. Pan, and P. Cresswell
Intracellular Formation and Cell Surface Expression of a Complex of an Intact Lysosomal Protein and MHC Class II Molecules
J. Immunol., June 15, 1998; 160(12): 5797 - 5806.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1986 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1986 by The American Association of Immunologists, Inc. All rights reserved.