The JI Acurri Cytometers
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bucy, R. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bucy, R. P.

The Journal of Immunology, Vol 137, Issue 3 809-813, Copyright © 1986 by American Association of Immunologists

ARTICLES

Alloantigen-specific suppressor T cells are not inhibited by cyclosporin A, but do require IL 2 for activation

RP Bucy

Alloantigen-specific suppressor T cells are activated from normal murine spleen cells in mixed lymphocyte reactions (MLR). These T cells are radioresistant and suppress the activation of cytotoxic T lymphocytes (CTL) in second primary MLR cultures. This report demonstrates that cyclosporin A (CsA) blocks the activation of these suppressor cells at a dose of 1 microgram/ml. However, reconstitution of CsA blocked cultures with IL 2 restores the activation of the suppressor T cells, but fails to significantly restore the activation of CTL in these same cultures. This differential activation requirement was used to establish T cell lines that demonstrate enriched suppressor cell activity but depletion of CTL activity. These findings are discussed in terms of the mechanism of action of CsA in these distinct T cell subsets and the relevance to models of allograft unresponsiveness.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
J. A. Kapp, K. Honjo, L. M. Kapp, K. Goldsmith, and R. P. Bucy
Antigen, in the Presence of TGF-beta, Induces Up-Regulation of FoxP3gfp+ in CD4+ TCR Transgenic T Cells That Mediate Linked Suppression of CD8+ T Cell Responses
J. Immunol., August 15, 2007; 179(4): 2105 - 2114.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. A. Kapp, K. Honjo, L. M. Kapp, X. y. Xu, A. Cozier, and R. P. Bucy
TCR transgenic CD8+ T cells activated in the presence of TGF{beta} express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection
Int. Immunol., November 1, 2006; 18(11): 1549 - 1562.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. L. Ierino, K. Yamada, T. Hatch, J. Rembert, and D. H. Sachs
Peripheral Tolerance to Class I Mismatched Renal Allografts in Miniature Swine: Donor Antigen-Activated Peripheral Blood Lymphocytes from Tolerant Swine Inhibit Antidonor CTL Reactivity
J. Immunol., January 1, 1999; 162(1): 550 - 559.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1986 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1986 by The American Association of Immunologists, Inc. All rights reserved.