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The Journal of Immunology, Vol 137, Issue 10 3254-3258, Copyright © 1986 by American Association of Immunologists
ARTICLES |
LE Samelson, AM Weissman, FA Robey, I Berkower and RD Klausner
The T cell antigen receptor consists of two disulfide-linked 40,000 to 45,000 dalton glycoproteins (alpha and beta) that contain variable and constant regions analogous to those found in immunoglobulin molecules. The antigen receptor on murine T cells is noncovalently associated with four additional nonpolymorphic structures. We describe an antibody that binds one of these molecules, a 26,000 dalton glycoprotein homologous to the human T3 delta-chain. This antibody immunoprecipitates the entire antigen receptor complex from a T cell hybridoma and from normal murine thymocytes. It represents the first reagent that can immunoprecipitate the antigen receptor complex on all murine T cells.
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S. Tiwari and A. M. Weissman Endoplasmic Reticulum (ER)-associated Degradation of T Cell Receptor Subunits. INVOLVEMENT OF ER-ASSOCIATED UBIQUITIN-CONJUGATING ENZYMES (E2s) J. Biol. Chem., May 4, 2001; 276(19): 16193 - 16200. [Abstract] [Full Text] [PDF]
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