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The Journal of Immunology, Vol 136, Issue 12 4561-4564, Copyright © 1986 by American Association of Immunologists

ARTICLES

Cloning, sequence, and expression of bovine interferon-gamma

DP Cerretti, K McKereghan, A Larsen, D Cosman, S Gillis and PE Baker

Bovine interferon-gamma (IFN-gamma) sequences have been isolated by screening a cDNA library with a human IFN-gamma cDNA probe. The cDNA library was constructed from RNA isolated from concanavalin A- stimulated bovine lymph node cells. The open reading frame predicts that the bovine IFN-gamma precursor is composed of 166 amino acids with a predicted m.w. of 19,393. Alignment of the amino acid sequence with human IFN-gamma indicates that mature bovine IFN-gamma is composed of 143 amino acids with a predicted m.w. of 16,858. It has an amino acid homology of 63% with human IFN-gamma, and 47% with murine IFN-gamma. Biologically active bovine IFN-gamma was synthesized in an Escherichia coli expression system.


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C. Raggo, M. Habermehl, L. A. Babiuk, and P. Griebel
The in vivo effects of recombinant bovine herpesvirus-1 expressing bovine interferon-{gamma}
J. Gen. Virol., November 1, 2000; 81(11): 2665 - 2673.
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