The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Phadke, K.
Right arrow Articles by Butler, L. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Phadke, K.
Right arrow Articles by Butler, L. D.

The Journal of Immunology, Vol 136, Issue 11 4085-4091, Copyright © 1986 by American Association of Immunologists

ARTICLES

Role of interleukin 1 and interleukin 2 in rat and mouse arthritis models

K Phadke, DG Carlson, BD Gitter and LD Butler

The production of interleukin 1 (IL 1) and interleukin 2 (IL 2) by macrophages and lymphocytes from three animal models commonly used for rheumatoid arthritis, viz. adjuvant-induced and type II collagen- induced rat arthritis, and MRL/1 murine arthritis was studied. Although the peritoneal macrophages from adjuvant-arthritic rats in culture produced increased amounts of prostaglandin E2 (PGE2) and lower levels of IL 1 than the control group, cells from collagen-arthritic rats released normal levels of PGE2, but increased amounts of IL 1. After activation with lipopolysaccharides, the IL 1 production by macrophages from all groups was comparable. Addition of indomethacin did not significantly change the IL 1 production in any of these groups. In the absence of any exogenous mitogen, IL 2 production by the lymphocytes of adjuvant-arthritic rats was low, but could be restored to the normal levels when phytohemagglutinin A (PHA) or concanavalin A (Con A) was added. The lymphocytes from collagen-arthritic rats were capable of producing IL 2 without the need of any T cell mitogen. The lymphocytes from MRL/1 mice seemed to lack the functionality in terms of IL 2 production. The macrophagic IL 1 production in these animals was normal. Our data suggest that the type II collagen arthritis model may closely resemble human rheumatoid arthritis in which IL 1 and IL 2 production by the mononuclear cells is significantly enhanced.


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
P Mukherjee, B Wu, L Mayton, S-H Kim, P D Robbins, and P H Wooley
TNF receptor gene therapy results in suppression of IgG2a anticollagen antibody in collagen induced arthritis
Ann Rheum Dis, August 1, 2003; 62(8): 707 - 714.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Philippe, P. Gegout-Pottie, C. Guingamp, K. Bordji, B. Terlain, P. Netter, and P. Gillet
Relations between functional, inflammatory, and degenerative parameters during adjuvant arthritis in rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1997; 273(4): R1550 - R1556.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. A. Rittenhouse and E. Redei
Thyroxine Administration Prevents Streptococcal Cell Wall-Induced Inflammatory Responses
Endocrinology, April 1, 1997; 138(4): 1434 - 1439.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1986 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1986 by The American Association of Immunologists, Inc. All rights reserved.