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The Journal of Immunology, Vol 136, Issue 1 44-47, Copyright © 1986 by American Association of Immunologists

ARTICLES

Cytolytic activity of antigen-specific T cells with helper phenotype

M Nakamura, DT Ross, TJ Briner and ML Gefter

We have investigated an unusual cytolytic activity displayed in vitro by cloned T cells which have the cell surface phenotype of helper T cells. When the cloned T cells are cultured with the appropriate antigen and antigen-presenting cells (APC), the T cells become activated in that they produce lymphokines and proliferate in an antigen-specific and major histocompatibility complex-restricted manner. At the same time, these T cells cause lysis of the APC. In addition, innocent non-histocompatible bystander cells present in the cultures can also be killed. The cytolytic activity may be involved in a mechanism of immune regulation.


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