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The Journal of Immunology, Vol 135, Issue 6 3817-3822, Copyright © 1985 by American Association of Immunologists

ARTICLES

B lymphocyte regulation of human hematopoiesis

FM Uckun, DA Vallera and SL Wee

Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines (BLCL) were derived from seven different individuals. The ability of BLCL supernatants to stimulate hematopoietic colony formation in vitro was tested in a conventional stem cell assay system. Supernatants promoted the growth of single (GM, E, MK) as well as multi-lineage (GEMM) colonies in bone marrow cultures. Our results indicate that EBV- transformed B lymphocytes produce cytokines that affect in vitro stem cell proliferation and differentiation. These studies demonstrate the regulatory potential of activated B lymphocytes in human hematopoiesis.




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