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The Journal of Immunology, Vol 135, Issue 6 3691-3696, Copyright © 1985 by American Association of Immunologists

ARTICLES

Expression of H-2I region-restricted cytolytic activity by an Lyt-2+ influenza virus-specific T lymphocyte clone

LA Morrison, VL Braciale and TJ Braciale

The expression of Lyt-2 on T lymphocytes has been postulated to correlate closely with restriction by, or alloreactivity to, class I MHC gene products, whereas I region-restricted or alloreactive populations appear to be associated with Lyt-1 and L3T4 expression. However, exceptions to this axiom among alloreactive T cells have been shown to exist. In this report we describe a clonal population of influenza virus-specific T lymphocytes that bears the Lyt-2+, L3T4- phenotype. Notably, this clone is restricted in influenza virus recognition by class II MHC molecules and is cytolytic for virus- infected target cells expressing the appropriate class II molecules. Antibody directed to the Lyt-2 molecule does not inhibit cytolysis.




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