| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 134, Issue 5 3307-3315, Copyright © 1985 by American Association of Immunologists
ARTICLES |
GD Ross, JA Cain and PJ Lachmann
Human leukocyte complement receptor type three (CR3) was shown to be lectin-like and to resemble bovine serum conglutinin (K) in that it bound to both iC3b and unopsonized yeast (Saccharomyces cerevisiae), and was inhibited by EDTA or N-acetyl-D-glucosamine (NADG). CR3 and K also bound to zymosan (Z), a yeast cell wall extract that contains primarily polysaccharide and no detectable protein. However, structural differences and the absence of K on bovine phagocytes indicated that CR3 was not the human homologue of bovine K. Phagocytic and respiratory responses to unopsonized Z were CR3 dependent because they were inhibited by monoclonal antibodies specific for the alpha-chain of CR3 and did not occur with phagocytes from patients with a genetic deficiency of CR3. The binding of CR3 to Z did not require opsonization of the Z with neutrophil-secreted C3, as Z binding and responses were not inhibited by Fab anti-C3. In addition, CR3-dependent binding of yeast occurred with neutrophils from which protein secretion was blocked by fixation with paraformaldehyde. Rabbit erythrocytes (RaE) also bound weakly to neutrophil CR3 and triggered ingestion. Anti-CR3 not only blocked the binding and ingestion of RaE but also blocked selectively the ingestion of RaEC3b without affecting the strong binding mediated by CR1. Even though sheep E and sheep EC3b were not ingested by neutrophils, a weak binding of CR3 to sheep E was suggested by the finding of 20 to 40% inhibition of sheep EAIgG ingestion by anti- CR3. Such inhibition was only observed in buffers that allowed activity of the CR3 binding site and not in buffers containing either EDTA or NADG. An apparently contradictory finding was that the weak CR3- dependent binding of Z triggered neutrophil ingestion and a superoxide burst, whereas the avid CR3-dependent binding of sheep EC3bi did not induce significant ingestion or a respiratory burst. Blocking studies with monoclonal antibodies specific for different epitopes of the alpha- chain of CR3 suggested that this might result from the presence of two distinct binding sites in CR3: one site for fixed iC3b that did not trigger functions, and a second function-triggering site for Z that did not bind to fixed iC3b.
This article has been cited by other articles:
|
|
 |
|
  M. Gil, F. X. McCormack, and A. M. LeVine Surfactant Protein A Modulates Cell Surface Expression of CR3 on Alveolar Macrophages and Enhances CR3-mediated Phagocytosis J. Biol. Chem., March 20, 2009; 284(12): 7495 - 7504. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. E. Morrison, J. D. Simmons, and M. T. Heise Complement Receptor 3 Promotes Severe Ross River Virus-Induced Disease J. Virol., November 15, 2008; 82(22): 11263 - 11272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. D. Kim, T. Miwa, Y. Kimura, R. A. Schwendener, M. van Lookeren Campagne, and W.-C. Song Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg Blood, August 15, 2008; 112(4): 1109 - 1119. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. B. Shah, Y. Huang, R. Keshwara, T. Ozment-Skelton, D. L. Williams, and L. Keshvara {beta}-Glucan Activates Microglia without Inducing Cytokine Production in Dectin-1-Dependent Manner J. Immunol., March 1, 2008; 180(5): 2777 - 2785. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. S. Lee, W. M. Nauseef, A. Moeenrezakhanlou, L. M. Sly, S. Noubir, K. G. Leidal, J. M. Schlomann, G. Krystal, and N. E. Reiner Monocyte p110{alpha} phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production J. Leukoc. Biol., June 1, 2007; 81(6): 1548 - 1561. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Skoberne, S. Somersan, W. Almodovar, T. Truong, K. Petrova, P. M. Henson, and N. Bhardwaj The apoptotic-cell receptor CR3, but not {alpha}vbeta5, is a regulator of human dendritic-cell immunostimulatory function Blood, August 1, 2006; 108(3): 947 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Megiovanni, F. Sanchez, M. Robledo-Sarmiento, C. Morel, J. C. Gluckman, and S. Boudaly Polymorphonuclear neutrophils deliver activation signals and antigenic molecules to dendritic cells: a new link between leukocytes upstream of T lymphocytes J. Leukoc. Biol., May 1, 2006; 79(5): 977 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nozaki, B. J. Raisler, E. Sakurai, J. V. Sarma, S. R. Barnum, J. D. Lambris, Y. Chen, K. Zhang, B. K. Ambati, J. Z. Baffi, et al. Drusen complement components C3a and C5a promote choroidal neovascularization PNAS, February 14, 2006; 103(7): 2328 - 2333. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Ehirchiou, Y.-M. Xiong, Y. Li, S. Brew, and L. Zhang Dual Function for a Unique Site within the {beta}2I Domain of Integrin {alpha}M{beta}2 J. Biol. Chem., March 4, 2005; 280(9): 8324 - 8331. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Villeneuve, M. Gilleron, I. Maridonneau-Parini, M. Daffe, C. Astarie-Dequeker, and G. Etienne Mycobacteria use their surface-exposed glycolipids to infect human macrophages through a receptor-dependent process J. Lipid Res., March 1, 2005; 46(3): 475 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.-Y. Hsu, K.-F. Hua, C.-C. Lin, C.-H. Lin, J. Hsu, and C.-H. Wong Extract of Reishi Polysaccharides Induces Cytokine Expression via TLR4-Modulated Protein Kinase Signaling Pathways J. Immunol., November 15, 2004; 173(10): 5989 - 5999. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Wu, K. H. Van der Hoek, N. K. Ryan, R. J. Norman, and R. L. Robker Macrophage contributions to ovarian function Hum. Reprod. Update, March 1, 2004; 10(2): 119 - 133. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. M. Hoffmeister, E. C. Josefsson, N. A. Isaac, H. Clausen, J. H. Hartwig, and T. P. Stossel Glycosylation Restores Survival of Chilled Blood Platelets Science, September 12, 2003; 301(5639): 1531 - 1534. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Xiong, J. Chen, and L. Zhang Modulation of CD11b/CD18 Adhesive Activity by Its Extracellular, Membrane-Proximal Regions J. Immunol., July 15, 2003; 171(2): 1042 - 1050. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-M. Xiong, T. A. Haas, and L. Zhang Identification of Functional Segments within the beta 2I-domain of Integrin alpha Mbeta 2 J. Biol. Chem., November 22, 2002; 277(48): 46639 - 46644. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Zen, Y. Liu, D. Cairo, and C. A. Parkos CD11b/CD18-Dependent Interactions of Neutrophils with Intestinal Epithelium Are Mediated by Fucosylated Proteoglycans J. Immunol., November 1, 2002; 169(9): 5270 - 5278. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. R. Taylor, G. D. Brown, D. M. Reid, J. A. Willment, L. Martinez-Pomares, S. Gordon, and S. Y. C. Wong The {beta}-Glucan Receptor, Dectin-1, Is Predominantly Expressed on the Surface of Cells of the Monocyte/Macrophage and Neutrophil Lineages J. Immunol., October 1, 2002; 169(7): 3876 - 3882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Le Cabec, S. Carreno, A. Moisand, C. Bordier, and I. Maridonneau-Parini Complement Receptor 3 (CD11b/CD18) Mediates Type I and Type II Phagocytosis During Nonopsonic and Opsonic Phagocytosis, Respectively J. Immunol., August 15, 2002; 169(4): 2003 - 2009. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Takahashi, J. Cohen-Solal, A. Galinha, W. H. Fridman, C. Sautes-Fridman, and K. Kato N-glycosylation profile of recombinant human soluble Fc{gamma} receptor III Glycobiology, August 1, 2002; 12(8): 507 - 515. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-J. Hsu, S.-S. Lee, and W.-W. Lin Polysaccharide purified from Ganoderma lucidum inhibits spontaneous and Fas-mediated apoptosis in human neutrophils through activation of the phosphatidylinositol 3 kinase/Akt signaling pathway J. Leukoc. Biol., July 1, 2002; 72(1): 207 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. B. Forsyth and H. L. Mathews Lymphocyte Adhesion to Candida albicans Infect. Immun., February 1, 2002; 70(2): 517 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Willment, S. Gordon, and G. D. Brown Characterization of the Human beta -Glucan Receptor and Its Alternatively Spliced Isoforms J. Biol. Chem., November 16, 2001; 276(47): 43818 - 43823. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Liese, M. Q. Siddiqi, J. H. Siegel, T. Denny, and Z. Spolarics Augmented TNF-{alpha} and IL-10 production by primed human monocytes following interaction with oxidatively modified autologous erythrocytes J. Leukoc. Biol., August 1, 2001; 70(2): 289 - 296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Prince, C. F. Brayton, M. C. Fossett, J. A. Durand, S. L. Kaplan, C. W. Smith, and C. M. Ballantyne The Differential Roles of LFA-1 and Mac-1 in Host Defense Against Systemic Infection with Streptococcus pneumoniae J. Immunol., June 15, 2001; 166(12): 7362 - 7369. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Bharadwaj, C. Mold, E. Markham, and T. W. Du Clos Serum Amyloid P Component Binds to Fc{{gamma}} Receptors and Opsonizes Particles for Phagocytosis J. Immunol., June 1, 2001; 166(11): 6735 - 6741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Peyron, C. Bordier, E.-N. N'Diaye, and I. Maridonneau-Parini Nonopsonic Phagocytosis of Mycobacterium kansasii by Human Neutrophils Depends on Cholesterol and Is Mediated by CR3 Associated with Glycosylphosphatidylinositol-Anchored Proteins J. Immunol., November 1, 2000; 165(9): 5186 - 5191. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Albanyan and M. S. Edwards Lectin Site Interaction with Capsular Polysaccharide Mediates Nonimmune Phagocytosis of Type III Group B Streptococci Infect. Immun., October 1, 2000; 68(10): 5794 - 5802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Fradin, D. Poulain, and T. Jouault beta -1,2-Linked Oligomannosides from Candida albicans Bind to a 32-Kilodalton Macrophage Membrane Protein Homologous to the Mammalian Lectin Galectin-3 Infect. Immun., August 1, 2000; 68(8): 4391 - 4398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Le Cabec, C. Cols, and I. Maridonneau-Parini Nonopsonic Phagocytosis of Zymosan and Mycobacterium kansasii by CR3 (CD11b/CD18) Involves Distinct Molecular Determinants and Is or Is Not Coupled with NADPH Oxidase Activation Infect. Immun., August 1, 2000; 68(8): 4736 - 4745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. K. Petersen, C. W. Smith, and A. L. Jensen Characterization of the Priming Effect by Pituitary Canine Growth Hormone on Canine Polymorphonuclear Neutrophil Granulocyte Function Clin. Vaccine Immunol., March 1, 2000; 7(2): 226 - 232. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Fitch, C. Doller, C. K. Combs, G. E. Landreth, and J. Silver Cellular and Molecular Mechanisms of Glial Scarring and Progressive Cavitation: In Vivo and In Vitro Analysis of Inflammation-Induced Secondary Injury after CNS Trauma J. Neurosci., October 1, 1999; 19(19): 8182 - 8198. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xia and G. D. Ross Generation of Recombinant Fragments of CD11b Expressing the Functional {beta}-Glucan-Binding Lectin Site of CR3 (CD11b/CD18) J. Immunol., June 15, 1999; 162(12): 7285 - 7293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Harler, E. Wakshull, E. J. Filardo, J. E. Albina, and J. S. Reichner Promotion of Neutrophil Chemotaxis Through Differential Regulation of {beta}1 and {beta}2 Integrins J. Immunol., June 1, 1999; 162(11): 6792 - 6799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xia, V. Vetvicka, J. Yan, M. Hanikyrova, T. Mayadas, and G. D. Ross The {beta}-Glucan-Binding Lectin Site of Mouse CR3 (CD11b/CD18) and Its Function in Generating a Primed State of the Receptor That Mediates Cytotoxic Activation in Response to iC3b-Opsonized Target Cells J. Immunol., February 15, 1999; 162(4): 2281 - 2290. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mevorach, J. O. Mascarenhas, D. Gershov, and K. B. Elkon Complement-dependent Clearance of Apoptotic Cells by Human Macrophages J. Exp. Med., December 21, 1998; 188(12): 2313 - 2320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Avni, Z. Pur, E. Yefenof, and M. Baniyash Complement Receptor 3 of Macrophages Is Associated with Galectin-1-Like Protein J. Immunol., June 15, 1998; 160(12): 6151 - 6158. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Klugewitz, K Ley, D Schuppan, R Nuck, P Gaehtgens, and B Walzog Activation of the beta2 integrin Mac-1 (CD11b/CD18) by an endogenous lipid mediator of human neutrophils and HL-60 cells J. Cell Sci., January 4, 1997; 110(8): 985 - 990. [Abstract] [PDF]
|
|
|
|
|
|
Z. Zhu, Z. Bao, and J. Li MacMARCKS Mutation Blocks Macrophage Phagocytosis of Zymosan J. Biol. Chem., July 28, 1995; 270(30): 17652 - 17655. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Mathew, C. S. Rinder, J. B. Tracey, L. A. Auszura, T. O'Connor, E. Davis, and B. R. Smith Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 448 - 456. [Abstract] [Full Text]
|
|
|
|
|
|
T.ás Szabó, J. L. Kadish, and J. K. Czop Biochemical Properties of the Ligand-binding 20-kDa Subunit of the beta-Glucan Receptors on Human Mononuclear Phagocytes J. Biol. Chem., February 3, 1995; 270(5): 2145 - 2151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Rinder, D. Gaal, L. A. Student, and B. R. Smith Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 280 - 288. [Abstract] [Full Text]
|
|
|
|
|
|
Y.-M. Xiong and L. Zhang Structure-Function of the Putative I-domain within the Integrin beta 2 Subunit J. Biol. Chem., May 25, 2001; 276(22): 19340 - 19349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Yalamanchili, C. Lu, C. Oxvig, and T. A. Springer Folding and Function of I Domain-deleted Mac-1 and Lymphocyte Function-associated Antigen-1 J. Biol. Chem., July 14, 2000; 275(29): 21877 - 21882. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
