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The Journal of Immunology, Vol 134, Issue 5 2966-2970, Copyright © 1985 by American Association of Immunologists

ARTICLES

Immunogenetic studies of spontaneous abortion in mice. Preimmunization of females with allogeneic cells

N Kiger, G Chaouat, JP Kolb, TG Wegmann and JL Guenet

CBA females (H-2k) mated with DBA2 males (H-2d) exhibit a high rate of fetal resorption (30%) when compared with the CBA female BALB/c male, CBA female/CBA male, DBA2 female/CBA male, DBA2 female/DBA2 male combinations (6 to 8%). Preimmunization of CBA females with spleen cells from DBA2, BALB/c, or CBA males were performed in order to test their effects on CBA maternal tolerance of (CBA X DBA2)F1 fetuses. Only preimmunization with BALB/c male cells was effective in decreasing resorption; cells from BALB/c females had no effect. In order to further test 1) the role of non-MHC-encoded antigens present in the BALB/c male background, 2) the necessity of an additional H-2 difference, and 3) whether or not the phenomenon is H-2d restricted, preimmunizations were performed by using cells from congenic BALB/k (H- 2k), BALB/b (H-2b), or BALB/c (H-2d). Only the latter treatment was efficient, which suggests that the paternal H-2d haplotype must be presented in synergy with some non-MHC-encoded antigens in the BALB/c male background. Immunogenetic studies with cells from nine recombinant inbred strains that reassorted DBA2 and BALB/c genomes showed that three of them behave like BALB/c and six like DBA2. This would suggest that the genetic determinism of this phenomenon is simple.


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W.-H. Zhou, L. Dong, M.-R. Du, X.-Y. Zhu, and D.-J. Li
Cyclosporin A improves murine pregnancy outcome in abortion-prone matings: involvement of CD80/86 and CD28/CTLA-4
Reproduction, March 1, 2008; 135(3): 385 - 395.
[Abstract] [Full Text] [PDF]

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M.-R. Du, L. Dong, W.-H. Zhou, F.-T. Yan, and D.-J. Li
Cyclosporin A Improves Pregnancy Outcome by Promoting Functions of Trophoblasts and Inducing Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings in the Mouse
Biol Reprod, May 1, 2007; 76(5): 906 - 914.
[Abstract] [Full Text] [PDF]


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