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The Journal of Immunology, Vol 134, Issue 3 1914-1919, Copyright © 1985 by American Association of Immunologists
ARTICLES |
VE Kelley, A Ferretti, S Izui and TB Strom
Dietary supplementation of fish oil as the exclusive source of lipid suppresses autoimmune lupus in MRL-lpr mice. This marine oil diet decreases the lymphoid hyperplasia regulated by the lpr gene, prevents an increase in macrophage surface Ia expression, reduces the formation of circulating retroviral gp70 immune complexes, delays the onset of renal disease, and prolongs survival. We show that a fatty acid component uniquely present in fish oil but not in vegetable oil decreases the quantity of dienoic prostaglandin E, thromboxane B, and prostacyclin normally synthesized by multiple tissues, including kidney, lung, and macrophages, and promotes the synthesis of small amounts of trienoic prostaglandin in autoimmune mice. We suggest that this change in endogenous cyclooxygenase metabolite synthesis directly suppresses immunologic and/or inflammatory mediators of murine lupus.
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 E. Soyland, J. Funk, G. Rajka, M. Sandberg, P. Thune, L. Rustad, S. Helland, K. Middelfart, S. Odu, E. S. Falk, et al. Effect of Dietary Supplementation with Very-Long-Chain n-3 Fatty Acids in Patients with Psoriasis N. Engl. J. Med., June 24, 1993; 328(25): 1812 - 1816. [Abstract] [Full Text]
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O. Trocki, T. J. Heyd, J. P. Waymack, and J. W. Alexander Effects of Fish Oil on Postburn Metabolism and Immunity JPEN J Parenter Enteral Nutr, November 1, 1987; 11(6): 521 - 528. [Abstract] [PDF]
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