The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kohl, S.
Right arrow Articles by Anderson, D. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kohl, S.
Right arrow Articles by Anderson, D. C.

The Journal of Immunology, Vol 133, Issue 6 2972-2978, Copyright © 1984 by American Association of Immunologists

ARTICLES

Defective natural killer cytotoxicity and polymorphonuclear leukocyte antibody-dependent cellular cytotoxicity in patients with LFA-1/OKM-1 deficiency

S Kohl, TA Springer, FC Schmalstieg, LS Loo and DC Anderson

Four children with an immunodeficiency involving the absence of leukocyte membrane glycoproteins reacting with anti-LFA-1 and OKM-1 monoclonal antibodies were unable to mediate adherence-dependent leukocyte functions. Even with normal Fc receptor function, their PMN- ADCC and MC-NKC were markedly deficient. Single cell analysis demonstrated deficient antibody-mediated PMN-target cell adherence. Monoclonal antibodies against LFA-1 and OKM-1 reproduced this immunodeficiency in leukocytes from normal adults. LFA-1/OKM-1 mediates a PMN-target cell adhesive step.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
D. F. Barber, M. Faure, and E. O. Long
LFA-1 Contributes an Early Signal for NK Cell Cytotoxicity
J. Immunol., September 15, 2004; 173(6): 3653 - 3659.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C. Wagner, C. Iking-Konert, B. Denefleh, S. Stegmaier, F. Hug, and G. M. Hansch
Granzyme B and perforin: constitutive expression in human polymorphonuclear neutrophils
Blood, February 1, 2004; 103(3): 1099 - 1104.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. S. Orange, K. E. Harris, M. M. Andzelm, M. M. Valter, R. S. Geha, and J. L. Strominger
The mature activating natural killer cell immunologic synapse is formed in distinct stages
PNAS, November 25, 2003; 100(24): 14151 - 14156.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Microbiol. Rev.Home page
T. Andrews and K. E. Sullivan
Infections in Patients with Inherited Defects in Phagocytic Function
Clin. Microbiol. Rev., October 1, 2003; 16(4): 597 - 621.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S.-Z. Wang, P. K. Smith, M. Lovejoy, J. J. Bowden, J. H. Alpers, and K. D. Forsyth
Shedding of L-selectin and PECAM-1 and upregulation of Mac-1 and ICAM-1 on neutrophils in RSV bronchiolitis
Am J Physiol Lung Cell Mol Physiol, November 1, 1998; 275(5): L983 - L989.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
D. D. Billadeau, K. M. Brumbaugh, C. J. Dick, R. A. Schoon, X. R. Bustelo, and P. J. Leibson
The Vav-Rac1 Pathway in Cytotoxic Lymphocytes Regulates the Generation of Cell-mediated Killing
J. Exp. Med., August 3, 1998; 188(3): 549 - 559.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
C. Wegner, R. Gundel, P Reilly, N Haynes, L. Letts, and R Rothlein
Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma
Science, January 26, 1990; 247(4941): 456 - 459.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.