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The Journal of Immunology, Vol 133, Issue 5 2288-2290, Copyright © 1984 by American Association of Immunologists

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Lyt-1 cells mediate acute murine experimental allergic encephalomyelitis

SL Hauser, HL Weiner, AK Bhan, ME Shapiro, M Che, WR Aldrich and NL Letvin

Adult SJL/J mice were depleted of T lymphocytes and were reconstituted with Lyt-1, Lyt-2, or Lyt-1 + Lyt-2 cells. After immunization with MSCH, severe acute EAE developed in the Lyt-1- and the Lyt-1 + Lyt-2- reconstituted mice. Only 25% of the Lyt-2-reconstituted mice developed signs of EAE, and in those EAE onset was delayed. Thus, Lyt-1 cells mediate EAE in the mouse.




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