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The Journal of Immunology, Vol 133, Issue 3 1174-1178, Copyright © 1984 by American Association of Immunologists

ARTICLES

Immunoregulation of T-dependent responses by a cloned dendritic cell

C Clayberger, RH DeKruyff, R Fay, M Pavlakis and H Cantor

We have described a cloned dendritic cell, Clone Den-1, which is a potent accessory cell for some T-dependent immune responses. Clone Den- 1 activates T cells in both autologous and allogeneic mixed lymphocyte reactions, but cannot present soluble antigen to T cells that co- recognize nominal antigen plus I-Ab gene products. In addition, Clone Den-1 or factors produced by it can reconstitute plaque-forming cell responses by accessory cell-depleted B plus T cells to the T-dependent antigen sheep red blood cells. The relationship of this clone to heterogeneous populations of dendritic cells and other accessory cells is discussed.


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D. N.J. Hart
Dendritic Cells: Unique Leukocyte Populations Which Control the Primary Immune Response
Blood, November 1, 1997; 90(9): 3245 - 3287.
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