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The Journal of Immunology, Vol 133, Issue 2 775-778, Copyright © 1984 by American Association of Immunologists


ARTICLES

Naturally occurring anti-interferon antibodies in Lou/c rats

J De Maeyer-Guignard, A Cachard-Thomas and E De Maeyer

Rats of the Lou/c strain have natural antibodies with binding and neutralizing activity against mouse and rat interferon. The antibodies can be purified on a column of goat IgG directed against rat IgG, and they have an affinity for protein A-Sepharose. They are already present in very young (2-wk-old) animals, and the titers increase with increasing age.





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