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The Journal of Immunology, Vol 133, Issue 1 277-280, Copyright © 1984 by American Association of Immunologists

ARTICLES

Release of discrete interferons by cytotoxic T lymphocytes in response to immune and nonimmune stimuli

MS Pasternack, MJ Bevan and JR Klein

We have examined the potential of murine cytotoxic T lymphocytes (CTL) to synthesize both IFN-gamma and IFN-alpha, beta by using three cloned antigen-reactive CTL lines. These lines, which produce IFN-gamma in an antigen-specific manner or after stimulation with mitogen, were also found to produce IFN-alpha, beta upon nonspecific contact with Newcastle disease virus. The requirement for viral integrity in this process has been examined. Virus infectivity was not necessary to stimulate the release of IFN-alpha, beta from CTL, but acid- inactivation of virus abrogated its IFN-inducing property.


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