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The Journal of Immunology, Vol 133, Issue 1 273-276, Copyright © 1984 by American Association of Immunologists

ARTICLES

Dexamethasone-mediated inhibition of human T cell growth factor and gamma-interferon messenger RNA

SK Arya, F Wong-Staal and RC Gallo

Glucocorticoids suppress the proliferation of human T lymphocytes. Activated T lymphocytes require T cell growth factor (TCGF) for proliferation. TCGF is produced by a subset of T lymphocytes, and this production is regulated at the TCGF mRNA level. Dexamethasone, a synthetic glucocorticoid, strongly inhibits the synthesis of TCGF mRNA in human normal peripheral blood lymphocytes stimulated in culture with phytohemagglutinin. It also inhibits the accumulation of gamma- interferon mRNA in these cells. This dual effect may in part explain some of the immunosuppressive and anti-inflammatory effects of glucocorticoids.


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