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The Journal of Immunology, Vol 132, Issue 6 3054-3057, Copyright © 1984 by American Association of Immunologists
ARTICLES |
DE Griswold, S Alessi, AM Badger, G Poste and N Hanna
The effect of histamine type 2 (H2) receptor antagonists, cimetidine and ranitidine, on the induction and expression of hapten-specific suppressor T cells was studied. The activity of DNBSO3 -induced suppressor cells was evaluated after adoptive transfer to naive syngeneic recipients. Treatment with cimetidine or ranitidine markedly inhibited suppressor T cell activity in a dose-related manner and enhanced the contact sensitivity response to DNFB. Both H2 antagonists were effective in inhibiting the expression and, to a lesser extent, the induction of suppressor T cells. In contrast, norburimamide , a non- H2 antagonist structurally related to cimetidine, was inactive. The relevance of these findings to the clinical observation of cimetidine- induced reversal of acquired tolerance to dinitrochlorobenzene in anergic patients is discussed.
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