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The Journal of Immunology, Vol 132, Issue 6 3011-3018, Copyright © 1984 by American Association of Immunologists

ARTICLES

Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines

ME Hemler, F Sanchez-Madrid, TJ Flotte, AM Krensky, SJ Burakoff, AK Bhan, TA Springer and JL Strominger

A glycoprotein complex of 210,000 and 130,000 m.w., found on mitogen or alloantigen-stimulated human T cells and not on other hematopoietic cells, has been defined by a monoclonal antibody (Mab). The components of this complex are a subset of a larger family of proteins (210,000, 165,000 and 130,000 m.w.) defined by a second Mab. In a panel of hematopoietic cell lines and cell types, only activated T cells (including the cell line HUT-102) express the 210,000/130,000 complex and these cells also express the IL 2 receptor, a characteristic marker for activated T cells. The 210,000/130,000 m.w. complex (reactive with the Mab TS2/7) is present on all long-term activated T cells, including both the OKT4 and OKT8 subsets. The 210,000 m.w. subunit is expressed only on activated T cells. Other lymphoid cells express either the 130,000 m.w. subunit alone (unactivated lymphocytes, thymocytes, HUT- 78) or the 130,000 subunit together with a 165,000 subunit (MOLT-4, HSB, and other leukemic T cell lines). The 210,000/130,000 m.w., 165,000/130,000 m.w. and 130,000 m.w. complexes are antigenically related in that all share reactivity with the Mab A- 1A5 . Among non- lymphoid hematopoietic cells and cell lines, none express the 210,000 m.w. chain; adherent cells (monocytes) and myeloid cell lines each express single proteins of 130,000 to 155,000 m.w. Granulocytes and red blood cells are negative and platelets express multiple bands (165,000 and 140,000 m.w.). Immunoperoxidase staining of tissue sections showed that a broad range of tissues and cell types had material cross- reactive with the lymphoid 130,000 m.w. protein. However, only a discrete subset of those tissues and cells including blood vessel walls, connective tissue, smooth muscle, kidney mesangial cells, and some non-cellular matrix tissue, had material cross-reactive with the 210,000 m.w. protein on activated T lymphocytes.


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F. Berditchevski, S. Chang, J. Bodorova, and M. E. Hemler
Generation of Monoclonal Antibodies to Integrin-associated Proteins. EVIDENCE THAT alpha 3beta 1 COMPLEXES WITH EMMPRIN/BASIGIN/OX47/M6
J. Biol. Chem., November 14, 1997; 272(46): 29174 - 29180.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
I. Tachibana, J. Bodorova, F. Berditchevski, M. M. Zutter, and M. E. Hemler
NAG-2, a Novel Transmembrane-4 Superfamily (TM4SF) Protein That Complexes with Integrins and Other TM4SF Proteins
J. Biol. Chem., November 14, 1997; 272(46): 29181 - 29189.
[Abstract] [Full Text] [PDF]

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 JCBHome page
L. Camper, D. Heinegard, and E. Lundgren-Akerlund
Integrin {alpha}2{beta}1 Is a Receptor for the Cartilage Matrix Protein Chondroadherin
J. Cell Biol., September 8, 1997; 138(5): 1159 - 1167.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
J. Takagi, T. Kamata, J. Meredith, W. Puzon-McLaughlin, and Y. Takada
Changing Ligand Specificities of alpha vbeta 1 and alpha vbeta 3 Integrins by Swapping a Short Diverse Sequence of the beta  Subunit
J. Biol. Chem., August 8, 1997; 272(32): 19794 - 19800.
[Abstract] [Full Text] [PDF]

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 Circ. Res.Home page
J. G. Pickering, S. Uniyal, C. M. Ford, T. Chau, M. A. Laurin, L. H. Chow, C. G. Ellis, J. Fish, and B. M. C. Chan
Fibroblast Growth Factor-2 Potentiates Vascular Smooth Muscle Cell Migration to Platelet-Derived Growth Factor : Upregulation of {alpha}2ß1 Integrin and Disassembly of Actin Filaments
Circ. Res., May 19, 1997; 80(5): 627 - 637.
[Abstract] [Full Text]

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 J. Clin. Endocrinol. Metab.Home page
A. J. Castelbaum, L. Ying, S. G. Somkuti, J. Sun, A. O. Ilesanmi, and B. A. Lessey
Characterization of Integrin Expression in a Well Differentiated Endometrial Adenocarcinoma Cell Line (Ishikawa)
J. Clin. Endocrinol. Metab., January 1, 1997; 82(1): 136 - 142.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
L. L. Smith, H.-K. Cheung, L. E. Ling, J. Chen, D. Sheppard, R. Pytela, and C. M. Giachelli
Osteopontin N-terminal Domain Contains a Cryptic Adhesive Sequence Recognized by alpha 9beta 1 Integrin
J. Biol. Chem., November 8, 1996; 271(45): 28485 - 28491.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R. J. Faull, J. Wang, D. I. Leavesley, W. Puzon, G. R. Russ, D. Vestweber, and Y. Takada
A Novel Activating Anti-beta 1 Integrin Monoclonal Antibody Binds to the Cysteine-rich Repeats in the beta 1 Chain
J. Biol. Chem., October 11, 1996; 271(41): 25099 - 25106.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
W. Puzon-McLaughlin and Y. Takada
Critical Residues for Ligand Binding in an I Domain-like Structure of the Integrin beta 1 Subunit
J. Biol. Chem., August 23, 1996; 271(34): 20438 - 20443.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
W. Puzon-McLaughlin, T. A. Yednock, and Y. Takada
Regulation of Conformation and Ligand Binding Function of Integrin alpha 5beta 1 by the beta 1 Cytoplasmic Domain
J. Biol. Chem., July 12, 1996; 271(28): 16580 - 16585.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
A. Luque, M. Gómez, W. Puzon, Y. Takada, F. Sánchez-Madrid, and C. Cabañas
Activated Conformations of Very Late Activation Integrins Detected by a Group of Antibodies (HUTS) Specific for a Novel Regulatory Region(355-425) of the Common beta1 Chain
J. Biol. Chem., May 10, 1996; 271(19): 11067 - 11075.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
G. O. Delwel, F. Hogervorst, and A. Sonnenberg
Cleavage of the alpha6A Subunit Is Essential for Activation of the alpha6Abeta1 Integrin by Phorbol 12-Myristate 13-Acetate
J. Biol. Chem., March 29, 1996; 271(13): 7293 - 7296.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
M. Muñoz, J. Serrador, F. Sánchez-Madrid, and J.ín Teixidó
A Region of the Integrin VLAalpha4 Subunit Involved in Homotypic Cell Aggregation and in Fibronectin but Not Vascular Cell Adhesion Molecule-1 Binding
J. Biol. Chem., February 2, 1996; 271(5): 2696 - 2702.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
G. Bazzoni, D.-T. Shih, C. A. Buck, and M. E. Hemler
Monoclonal Antibody 9EG7 Defines a Novel beta(1) Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by Calcium
J. Biol. Chem., October 27, 1995; 270(43): 25570 - 25577.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
E. H. J. Danen, S.-i. Aota, A. A. van Kraats, K. M. Yamada, D. J. Ruiter, and G. N. P. van Muijen
Requirement for the Synergy Site for Cell Adhesion to Fibronectin Depends on the Activation State of Integrin alpha5beta1
J. Biol. Chem., September 15, 1995; 270(37): 21612 - 21618.
[Abstract] [Full Text] [PDF]

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 ScienceHome page
J Meredith Jr, Y Takada, M Fornaro, L. Languino, and M. Schwartz
Inhibition of cell cycle progression by the alternatively spliced integrin beta 1C
Science, September 15, 1995; 269(5230): 1570 - 1572.
[Abstract] [PDF]

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 Circ. Res.Home page
R. T. Lee, F. Berditchevski, G. C. Cheng, and M. E. Hemler
Integrin-Mediated Collagen Matrix Reorganization by Cultured Human Vascular Smooth Muscle Cells
Circ. Res., February 1, 1995; 76(2): 209 - 214.
[Abstract] [Full Text]

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 J. Cell Sci.Home page
J. Weitzman, A Chen, and M. Hemler
Investigation of the role of beta 1 integrins in cell-cell adhesion
J. Cell Sci., January 11, 1995; 108(11): 3635 - 3644.
[Abstract] [PDF]

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 J. Cell Sci.Home page
J. Marshall, D. Rutherford, A. McCartney, F Mitjans, S. Goodman, and I. Hart
Alpha v beta 1 is a receptor for vitronectin and fibrinogen, and acts with alpha 5 beta 1 to mediate spreading on fibronectin
J. Cell Sci., January 3, 1995; 108(3): 1227 - 1238.
[Abstract] [PDF]

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 J. Cell Sci.Home page
P Simon-Assmann, C Leberquier, N Molto, T Uezato, F Bouziges, and M Kedinger
Adhesive properties and integrin expression profiles of two colonic cancer populations differing by their spreading on laminin
J. Cell Sci., January 3, 1994; 107(3): 577 - 587.
[Abstract] [PDF]

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 J. Cell Sci.Home page
G. Dickson, A. Azad, G. E. Morris, H. Simon, M. Noursadeghi, and F. S. Walsh
Co-localization and molecular association of dystrophin with laminin at the surface of mouse and human myotubes
J. Cell Sci., December 1, 1992; 103(4): 1223 - 1233.
[Abstract] [PDF]

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 J. Cell Sci.Home page
P. Kaur and W. G. Carter
Integrin expression and differentiation in transformed human epidermal cells is regulated by fibroblasts
J. Cell Sci., November 1, 1992; 103(3): 755 - 763.
[Abstract] [PDF]

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 LupusHome page
J. Alcocer-Varela, D. Aleman-Hoey, and D. Alarcon-Segovia
Interleukin-1 and Interleukin-6 Activities are Increased in the Cerebrospinal Fluid of Patients with CNS Lupus Erythematosus and Correlate with Local Late T-Cell Activation Markers
Lupus, February 1, 1992; 1(2): 111 - 117.
[Abstract] [PDF]

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 JDRHome page
M. Hormia, J. Ylanne, and I. Virtanen
Expression of Integrins in Human Gingiva
Journal of Dental Research, December 1, 1990; 69(12): 1817 - 1823.
[Abstract] [PDF]

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 J. Biol. Chem.Home page
V. Wixler, D. Geerts, E. Laplantine, D. Westhoff, N. Smyth, M. Aumailley, A. Sonnenberg, and M. Paulsson
The LIM-only Protein DRAL/FHL2 Binds to the Cytoplasmic Domain of Several alpha and beta Integrin Chains and Is Recruited to Adhesion Complexes
J. Biol. Chem., October 20, 2000; 275(43): 33669 - 33678.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
H. Takahashi, T. Isobe, S. Horibe, J. Takagi, Y. Yokosaki, D. Sheppard, and Y. Saito
Tissue Transglutaminase, Coagulation Factor XIII, and the Pro-polypeptide of von Willebrand Factor Are All Ligands for the Integrins alpha 9beta 1 and alpha 4beta 1
J. Biol. Chem., July 28, 2000; 275(31): 23589 - 23595.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
T. Tarui, A. P. Mazar, D. B. Cines, and Y. Takada
Urokinase-type Plasminogen Activator Receptor (CD87) Is a Ligand for Integrins and Mediates Cell-Cell Interaction
J. Biol. Chem., February 2, 2001; 276(6): 3983 - 3990.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C. Claas, C. S. Stipp, and M. E. Hemler
Evaluation of Prototype Transmembrane 4 Superfamily Protein Complexes and Their Relation to Lipid Rafts
J. Biol. Chem., March 9, 2001; 276(11): 7974 - 7984.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
R. G. Rodrigues, N.-h. Guo, L. Zhou, J. M. Sipes, S. B. Williams, N. S. Templeton, H. R. Gralnick, and D. D. Roberts
Conformational Regulation of the Fibronectin Binding and alpha 3beta 1 Integrin-mediated Adhesive Activities of Thrombospondin-1
J. Biol. Chem., July 20, 2001; 276(30): 27913 - 27922.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
X. A. Zhang, A. L. Bontrager, and M. E. Hemler
Transmembrane-4 Superfamily Proteins Associate with Activated Protein Kinase C (PKC) and Link PKC to Specific beta 1 Integrins
J. Biol. Chem., June 29, 2001; 276(27): 25005 - 25013.
[Abstract] [Full Text] [PDF]

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 J. Biol. Chem.Home page
C. S. Stipp, T. V. Kolesnikova, and M. E. Hemler
EWI-2 Is a Major CD9 and CD81 Partner and Member of a Novel Ig Protein Subfamily
J. Biol. Chem., October 26, 2001; 276(44): 40545 - 40554.
[Abstract] [Full Text] [PDF]

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 JCBHome page
Z. Li, M. J. Calzada, J. M. Sipes, J. A. Cashel, H. C. Krutzsch, D. S. Annis, D. F. Mosher, and D. D. Roberts
Interactions of thrombospondins with {alpha}4{beta}1 integrin and CD47 differentially modulate T cell behavior
J. Cell Biol., April 29, 2002; 157(3): 509 - 519.
[Abstract] [Full Text] [PDF]


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