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The Journal of Immunology, Vol 132, Issue 5 2180-2182, Copyright © 1984 by American Association of Immunologists

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LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation

AM Krensky, E Robbins, TA Springer and SJ Burakoff

Three cell surface antigens associated with the CTL-target cell interaction were previously identified by generation of mAb against OKT4+, HLA-DR-specific CTL, and selection for inhibition of cytolysis in a 51Cr-release assay. In this report, we showed that these mAb inhibit cytolysis by blocking CTL-target cell conjugate formation. It appears that LFA-1, LFA-2, and LFA-3 are cell surface structures involved in strengthening effector-target adhesion that accompanies antigen-specific recognition.


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