The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quaranta, V.
Right arrow Articles by Knapp, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quaranta, V.
Right arrow Articles by Knapp, W.

The Journal of Immunology, Vol 132, Issue 4 1900-1905, Copyright © 1984 by American Association of Immunologists

ARTICLES

A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3)

V Quaranta, O Majdic, G Stingl, K Liszka, H Honigsmann and W Knapp

An antigenic determinant present in the cytoplasm, but not on the surface membrane of human Ia+ cells, is defined by a monoclonal antibody (VIC-Y1) and is shown by immunoprecipitation and by NEPHGE to be expressed by Ia oligomers. Immunoprecipitations of cellfree translates and of purified Ia subunits indicate that the VIC-Y1 determinant is located on the Ia gamma-(invariant) chain, as well as on two other related molecules, provisionally termed gamma 2 and gamma 3. Within our experimental conditions, the three forms of gamma-chains co- precipitate exclusively with Ia oligomers. As detected by VIC-Y1 and in the limits of our assays, gamma-chains could not be found at the cell surface; their tissue distribution, determined by cytoplasmic indirect immunofluorescence with VIC-Y1, closely resembles that of Ia antigens, with the possible exception of acute lymphatic leukemia cells (Ia+, gamma-chain-).


This article has been cited by other articles:


Home page
 Int ImmunolHome page
T. F. Gregers, B. Fleckenstein, F. Vartdal, P. Roepstorff, O. Bakke, and I. Sandlie
MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation
Int. Immunol., November 1, 2003; 15(11): 1291 - 1299.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Muntasell, M. Carrascal, L. Serradell, P. v. Veelen, F. Verreck, F. Koning, G. Raposo, J. Abian, and D. Jaraquemada
HLA-DR4 Molecules in Neuroendocrine Epithelial Cells Associate to a Heterogeneous Repertoire of Cytoplasmic and Surface Self Peptides
J. Immunol., November 1, 2002; 169(9): 5052 - 5060.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
T. W. Nordeng, T. F. Gregers, T. L. Kongsvik, S. Meresse, J.-P. Gorvel, F. Jourdan, A. Motta, and O. Bakke
The Cytoplasmic Tail of Invariant Chain Regulates Endosome Fusion and Morphology
Mol. Biol. Cell, June 1, 2002; 13(6): 1846 - 1856.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
S. Badve, C. Deshpande, Z. Hua, and L. Logdberg
Expression of Invariant Chain (CD 74) and Major Histocompatibility Complex (MHC) Class II Antigens in the Human Fetus
J. Histochem. Cytochem., April 1, 2002; 50(4): 473 - 482.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Pond and C. Watts
Functional Early Endosomes Are Required for Maturation of Major Histocompatibility Complex Class II Molecules in Human B Lymphoblastoid Cells
J. Biol. Chem., June 18, 1999; 274(25): 18049 - 18054.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
M. Catalfamo, L. Serradell, C. Roura-Mir, E. Kolkowski, M. Sospedra, M. Vives-Pi, F. Vargas-Nieto, R. Pujol-Borrell, and D. Jaraquemada
HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules
Int. Immunol., February 1, 1999; 11(2): 269 - 277.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
R Wubbolts, M Fernandez-Borja, I Jordens, E Reits, S Dusseljee, C Echeverri, R. Vallee, and J Neefjes
Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments
J. Cell Sci., January 3, 1999; 112(6): 785 - 795.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
I. M. Siebenkotten, C. Carstens, and N. Koch
Identification of a Sequence That Mediates Promiscuous Binding of Invariant Chain to MHC Class II Allotypes
J. Immunol., April 1, 1998; 160(7): 3355 - 3362.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Lightstone, R. Hargreaves, G. Bobek, M. Peterson, G. Aichinger, G. Lombardi, and R. Lechler
In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DM
PNAS, May 27, 1997; 94(11): 5772 - 5777.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J.-P. Gorvel, J.-M. Escola, E. Stang, and O. Bakke
Invariant Chain Induces a Delayed Transport from Early to Late Endosomes
J. Biol. Chem., February 10, 1995; 270(6): 2741 - 2746.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J Pieters, O Bakke, and B Dobberstein
The MHC class II-associated invariant chain contains two endosomal targeting signals within its cytoplasmic tail
J. Cell Sci., January 11, 1993; 106(3): 831 - 846.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
S. Zachgo, B. Dobberstein, and G. Griffiths
A block in degradation of MHC class II-associated invariant chain correlates with a reduction in transport from endosome carrier vesicles to the prelysosome compartment
J. Cell Sci., November 1, 1992; 103(3): 811 - 822.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.