The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lemonnier, F. A.
Right arrow Articles by Jordan, B. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lemonnier, F. A.
Right arrow Articles by Jordan, B. R.

The Journal of Immunology, Vol 132, Issue 3 1176-1182, Copyright © 1984 by American Association of Immunologists

ARTICLES

Transformation of LMTK- cells with purified class I genes. V. Antibody- induced structural modification of HLA class I molecules results in potentiation of the fixation of a second monoclonal antibody

FA Lemonnier, PP Le Bouteiller, D Olive, B Malissen, Z Mishal, C Layet, J Dubreuil, DH Caillol, FM Kourilsky and BR Jordan

A potentiation phenomenon was observed with HLA-A3 and CW3 transformed murine L cells between anti-HLA class I B10.6 (potentiated) and B10.8 (potentiating) monoclonal antibodies (m.Ab.). Further studies of this phenomenon with these transformed L cells indicated that: 1) no significant specific binding of B10.6 m.Ab. to HLA-A3 and CW3 transformed L cells could be demonstrated by conventional radioimmunoassay or cytofluorometric study in the absence of B10.8 m.Ab.; 2) potentiation of the fixation of B10.6 m.Ab. was induced by other anti-HLA class I m.Ab., which all reacted with the same cluster of antigenic determinants; 3) potentiation reflects an increased specific fixation of B10.6 m.Ab. to HLA class I molecules implicating its combining site; 4) potentiation was mediated by B10.8 Fab fragments. These results indicate that potentiation of the fixation of B10.6 m.Ab. to the HLA-A3 and CW3 molecules expressed by the transformed L cells reflects conformational changes of these molecules after interaction with B10.8 m.Ab.


This article has been cited by other articles:


Home page
 Int ImmunolHome page
M. T. Barel, N. Pizzato, P. Le Bouteiller, E. J. H. J. Wiertz, and F. Lenfant
Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation
Int. Immunol., January 1, 2006; 18(1): 173 - 182.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
M. Derrien, N. Pizzato, G. Dolcini, E. Menu, G. Chaouat, F. Lenfant, F. Barre-Sinoussi, and P. L. Bouteiller
Human immunodeficiency virus 1 downregulates cell surface expression of the non-classical major histocompatibility class I molecule HLA-G1
J. Gen. Virol., July 1, 2004; 85(7): 1945 - 1954.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. T. Barel, M. Ressing, N. Pizzato, D. van Leeuwen, P. Le Bouteiller, F. Lenfant, and E. J. H. J. Wiertz
Human Cytomegalovirus-Encoded US2 Differentially Affects Surface Expression of MHC Class I Locus Products and Targets Membrane-Bound, but Not Soluble HLA-G1 for Degradation
J. Immunol., December 15, 2003; 171(12): 6757 - 6765.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.