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The Journal of Immunology, Vol 132, Issue 3 1124-1129, Copyright © 1984 by American Association of Immunologists

ARTICLES

Mechanisms of contact photosensitivity in mice. IV. Antigen-specific suppressor T cells induced by preirradiation of photosensitizing site to UVB

M Takigawa, Y Miyachi, K Toda and A Yoshioka

Mice were successfully contact photosensitized with 3,3',4',5- tetrachlorosalicylanilide (TCSA) plus black light irradiation. Pre- exposure of the photosensitizing site (ca 5 cm2) to UVB (280 to 320 nm; 400 mJ/cm2) rendered mice unresponsive to a challenge reaction. Cell transfer experiments demonstrated that the spleens from the nonreactive mice contained suppressor T cells (Ts) that were antigen-specific and that blocked the afferent limb of contact photosensitivity to TCSA. To exert suppressive functions, Ts required another population of cyclophosphamide-sensitive T cells that resided in the spleens of nonsensitized mice. The results provide evidence that UVB-induced aberrant homeostasis of the skin caused a marked suppression of immune system that is associated with the generation of Ts.


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V. K. Shreedhar, M. W. Pride, Y. Sun, M. L. Kripke, and F. M. Strickland
Origin and Characteristics of Ultraviolet-B Radiation-Induced Suppressor T Lymphocytes
J. Immunol., August 1, 1998; 161(3): 1327 - 1335.
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