| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
The Journal of Immunology, Vol 132, Issue 2 745-750, Copyright © 1984 by American Association of Immunologists
ARTICLES |
RP Kimberly, JE Salmon, JB Bussel, MK Crow and MW Hilgartner
To assess the effects on mononuclear phagocyte function of i.v. gamma- globulin treatment in idiopathic thrombocytopenic purpura, we examined in vivo and in vitro mononuclear phagocyte function in 11 patients before and after therapy. All patients, both splenectomized and non- splenectomized, demonstrated a prolongation of in vivo clearance of autologous IgG-sensitized erythrocytes (p less than 0.01). Concurrent in vitro assessment of blood monocyte function showed decreased IgG- sensitized erythrocyte (EA) rosette formation (mean +/- SD: 31.6% +/- 8.2 vs 24.5% +/- 9.5; p less than 0.03) and decreased affinity of Fc receptor-specific IgG oligomer binding (9.9 +/- 16.3 vs 1.8 +/- 2.1 X 10(8) M-1; p less than 0.008), but no consistent change in the estimate of the maximum number of binding sites. Phagocytosis of two different EA probes was decreased (EhuA:0.49 +/- 0.26 vs 0.25 +/- 0.14 erythrocyte/monocyte/hr; p less than 0.02, EoxA: 1.76 +/- 0.66 vs 1.27 +/- 0.67 erythrocyte/monocyte/hr, p less than 0.05). The change in in vivo mononuclear phagocyte system clearance was significantly correlated with the change in the association constant for oligomer binding (r = 0.98, p less than 0.05). These data demonstrate that i.v. gamma-globulin infusions induce alterations of mononuclear phagocyte function that are not dependent on the presence of autologous serum containing infusate. The change in apparent Fc receptor affinity rather than receptor number may reflect an altered Fc receptor population with different binding properties.
This article has been cited by other articles:
|
|
 |
|
  E. Roy, E. Stavropoulos, J. Brennan, S. Coade, E. Grigorieva, B. Walker, B. Dagg, R. E. Tascon, D. B. Lowrie, M. J. Colston, et al. Therapeutic Efficacy of High-Dose Intravenous Immunoglobulin in Mycobacterium tuberculosis Infection in Mice Infect. Immun., September 1, 2005; 73(9): 6101 - 6109. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. SAPIR, M. BLANK, and Y. SHOENFELD Immunomodulatory Effects of Intravenous Immunoglobulins as a Treatment for Autoimmune Diseases, Cancer, and Recurrent Pregnancy Loss Ann. N.Y. Acad. Sci., June 1, 2005; 1051(1): 743 - 778. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lamoureux, E. Aubin, and R. Lemieux Autoantibodies purified from therapeutic preparations of intravenous immunoglobulins (IVIg) induce the formation of autoimmune complexes in normal human serum: a role in the in vivo mechanisms of action of IVIg? Int. Immunol., July 1, 2004; 16(7): 929 - 936. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Lamoureux, E. Aubin, and R. Lemieux Autoimmune complexes in human serum in presence of therapeutic amounts of intravenous immunoglobulins Blood, February 15, 2003; 101(4): 1660 - 1660. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Gomez, P. Ruiz, R. Lopez, and C. Rivera Treatment with Megestrol Acetate Improves Human Immunodeficiency Virus-Associated Immune Thrombocytopenia Clin. Vaccine Immunol., May 1, 2002; 9(3): 583 - 587. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Kazatchkine and S. V. Kaveri Immunomodulation of Autoimmune and Inflammatory Diseases with Intravenous Immune Globulin N. Engl. J. Med., September 6, 2001; 345(10): 747 - 755. [Full Text] [PDF]
|
|
|
|
|
|
F. Gomez, P. Ruiz, J. A. Bernal, M. Escobar, A. Garcia-Egido, and J. J. B. Lopez-Saez Enhancement of Splenic-Macrophage Fc{gamma} Receptor Expression by Treatment with Estrogens Clin. Vaccine Immunol., July 1, 2001; 8(4): 806 - 810. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Gomez, P. Ruiz, R. Lopez, C. Rivera, S. Romero, and J. A. Bernal Effects of Androgen Treatment on Expression of Macrophage Fcgamma Receptors Clin. Vaccine Immunol., July 1, 2000; 7(4): 682 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. G. Sturgill, R. A. Drachtman, A. G. Ettinger, J. Rubin, and L. J. Ettinger The Influence of Epstein-Barr Virus Seropositivity on the Efficacy of Intravenous Immune Globulin in Children with Immune Thrombocytopenic Purpura Clinical Pediatrics, April 1, 1999; 38(3): 171 - 173. [PDF]
|
|
|
|
|
|
R. Rieben, A. Roos, Y. Muizert, C. Tinguely, A. F. Gerritsen, and M. R. Daha Immunoglobulin M-Enriched Human Intravenous Immunoglobulin Prevents Complement Activation In Vitro and In Vivo in a Rat Model of Acute Inflammation Blood, February 1, 1999; 93(3): 942 - 951. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
