The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Janeway, C. A.
Right arrow Articles by Murphy, D. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Janeway, C. A., Jr
Right arrow Articles by Murphy, D. B.

The Journal of Immunology, Vol 132, Issue 2 662-667, Copyright © 1984 by American Association of Immunologists

ARTICLES

Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells

CA Janeway Jr, PJ Conrad, EA Lerner, J Babich, P Wettstein and DB Murphy

Two monoclonal antibodies, Y-3P and Y-8P, specific for conventional mouse Ia glycoprotein antigens are described. Both were raised by repeated immunization of primed mice with activated T cells over a period of 1 yr, and both detect a new and broad public Ia specificity. Both of the antibodies react with I-A subregion-controlled A alpha:A beta complexes of all mouse strains apart from the responder strain (H- 2d), as well as the equivalent of A alpha:A beta complexes in rats carrying seven independent haplotypes. These antibodies have great utility as almost universal Ia reagents. On the basis of these results, we propose that Ia antigens presented to the immune system bound to activated T cells are immunogenic, and may induce the production of Ia antibodies of novel and broad specificity. In addition, we propose that such bound Ia glycoproteins could be a target for immunoregulatory T cells, and could account for the specificity of suppression of graft-vs- host reactions and Ia-restricted helper T cells observed by others in F1 animals injected with parental T cells.


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M. Kasai, I. Tanida, T. Ueno, E. Kominami, S. Seki, T. Ikeda, and T. Mizuochi
Autophagic Compartments Gain Access to the MHC Class II Compartments in Thymic Epithelium
J. Immunol., December 1, 2009; 183(11): 7278 - 7285.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. M. Rojo, E. Pini, G. Ojeda, R. Bello, C. Dong, R. A. Flavell, U. Dianzani, and P. Portoles
CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo'
Int. Immunol., April 1, 2008; 20(4): 577 - 589.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. P. Karunakaran, J. Rey-Ladino, N. Stoynov, K. Berg, C. Shen, X. Jiang, B. R. Gabel, H. Yu, L. J. Foster, and R. C. Brunham
Immunoproteomic Discovery of Novel T Cell Antigens from the Obligate Intracellular Pathogen Chlamydia
J. Immunol., February 15, 2008; 180(4): 2459 - 2465.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
X. Chen and P. E. Jensen
Cutting Edge: Primary B Lymphocytes Preferentially Expand Allogeneic FoxP3+ CD4 T Cells
J. Immunol., August 15, 2007; 179(4): 2046 - 2050.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
Y. Kuwano, C. M. Prazma, N. Yazawa, R. Watanabe, N. Ishiura, A. Kumanogoh, H. Okochi, K. Tamaki, M. Fujimoto, and T. F. Tedder
CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells
Int. Immunol., August 1, 2007; 19(8): 977 - 992.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
I. Tsunoda, T. Tanaka, E. J. Terry, and R. S. Fujinami
Contrasting Roles for Axonal Degeneration in an Autoimmune versus Viral Model of Multiple Sclerosis: When Can Axonal Injury Be Beneficial?
Am. J. Pathol., January 1, 2007; 170(1): 214 - 226.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. J. Guyver, D. A. Copland, C. J. Calder, A. Sette, J. Sidney, A. D. Dick, and L. B. Nicholson
Mapping Immune Responses to mRBP-3 1-16 Peptide with Altered Peptide Ligands
Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 2027 - 2035.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
I. Tsunoda, L.-Q. Kuang, M. Kobayashi-Warren, and R. S. Fujinami
Central Nervous System Pathology Caused by Autoreactive CD8+ T-Cell Clones following Virus Infection
J. Virol., December 1, 2005; 79(23): 14640 - 14646.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
Z. Karabekian, S. D. Lytton, P. B. Silver, Y. V. Sergeev, J. P. Schneck, and R. R. Caspi
Antigen/MHC Class II/Ig Dimers for Study of Uveitogenic T Cells: IRBP p161-180 Presented by both IA and IE Molecules
Invest. Ophthalmol. Vis. Sci., October 1, 2005; 46(10): 3769 - 3776.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
N. N. Logunova, C. Viret, L. A. Pobezinsky, S. A. Miller, D. B. Kazansky, J. P. Sundberg, and A. V. Chervonsky
Restricted MHC-peptide repertoire predisposes to autoimmunity
J. Exp. Med., July 5, 2005; 202(1): 73 - 84.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
M. A. Parent, K. N. Berggren, I. K. Mullarky, F. M. Szaba, L. W. Kummer, J. J. Adamovicz, and S. T. Smiley
Yersinia pestis V Protein Epitopes Recognized by CD4 T Cells
Infect. Immun., April 1, 2005; 73(4): 2197 - 2204.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. K. Dissanayake, N. Tuera, and S. Ostrand-Rosenberg
Presentation of Endogenously Synthesized MHC Class II-Restricted Epitopes by MHC Class II Cancer Vaccines Is Independent of Transporter Associated with Ag Processing and the Proteasome
J. Immunol., February 15, 2005; 174(4): 1811 - 1819.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
A. Dani, A. Chaudhry, P. Mukherjee, D. Rajagopal, S. Bhatia, A. George, V. Bal, S. Rath, and S. Mayor
The pathway for MHCII-mediated presentation of endogenous proteins involves peptide transport to the endo-lysosomal compartment
J. Cell Sci., August 15, 2004; 117(18): 4219 - 4230.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. Martinez-Soria, N. Ibnou-Zekri, M. Iwamoto, M.-L. Santiago-Raber, S. Kikuchi, M. Kosco-Vilbois, and S. Izui
Epitope-Dependent Inhibition of T Cell Activation by the Ea Transgene: An Explanation for Transgene-Mediated Protection from Murine Lupus
J. Immunol., August 15, 2004; 173(4): 2842 - 2848.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Honey, K. Forbush, P. E. Jensen, and A. Y. Rudensky
Effect of Decreasing the Affinity of the Class II-Associated Invariant Chain Peptide on the MHC Class II Peptide Repertoire in the Presence or Absence of H-2M1
J. Immunol., April 1, 2004; 172(7): 4142 - 4150.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
J. C. Huang, M. Vestberg, A. Minguela, R. Holmdahl, and E. S. Ward
Analysis of autoreactive T cells associated with murine collagen-induced arthritis using peptide-MHC multimers
Int. Immunol., February 1, 2004; 16(2): 283 - 293.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
K. Honey, T. Nakagawa, C. Peters, and A. Rudensky
Cathepsin L Regulates CD4+ T Cell Selection Independently of Its Effect on Invariant Chain: A Role in the Generation of Positively Selecting Peptide Ligands
J. Exp. Med., May 20, 2002; 195(10): 1349 - 1358.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C.-S. Hsieh, P. deRoos, K. Honey, C. Beers, and A. Y. Rudensky
A Role for Cathepsin L and Cathepsin S in Peptide Generation for MHC Class II Presentation
J. Immunol., March 15, 2002; 168(6): 2618 - 2625.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Zuo, C. M. Cullen, M. L. DeLay, S. Thornton, L. K. Myers, E. F. Rosloniec, G. P. Boivin, and R. Hirsch
A Single-Chain Class II MHC-IgG3 Fusion Protein Inhibits Autoimmune Arthritis by Induction of Antigen-Specific Hyporesponsiveness
J. Immunol., March 1, 2002; 168(5): 2554 - 2559.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
S. J. Bensinger, A. Bandeira, M. S. Jordan, A. J. Caton, and T. M. Laufer
Major Histocompatibility Complex Class II-Positive Cortical Epithelium Mediates the Selection of Cd4+25+ Immunoregulatory T Cells
J. Exp. Med., August 20, 2001; 194(4): 427 - 438.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Chen, B. T. Huber, R. J. Grand, and W. Li
Recombinant Adenovirus Coexpressing Covalent Peptide/MHC Class II Complex and B7-1: In Vitro and In Vivo Activation of Myelin Basic Protein-Specific T Cells
J. Immunol., August 1, 2001; 167(3): 1297 - 1305.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. V. Golovkina, Y. Agafonova, D. Kazansky, and A. Chervonsky
Diverse Repertoire of the MHC Class II-Peptide Complexes Is Required for Presentation of Viral Superantigens
J. Immunol., February 15, 2001; 166(4): 2244 - 2250.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H Vincent-Schneider, C Thery, D Mazzeo, D Tenza, G Raposo, and C Bonnerot
Secretory granules of mast cells accumulate mature and immature MHC class II molecules
J. Cell Sci., January 1, 2001; 114(2): 323 - 334.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
C. Viret, X. He, and C. A. Janeway Jr.
On the Self-Referential Nature of Naive MHC Class II-Restricted T Cells
J. Immunol., December 1, 2000; 165(11): 6183 - 6192.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. G. Radu, S. M. Anderton, M. Firan, D. C. Wraith, and E. S. Ward
Detection of autoreactive T cells in H-2u mice using peptide-MHC multimers
Int. Immunol., November 1, 2000; 12(11): 1553 - 1560.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Viret and C. A. Janeway Jr.
Functional and Phenotypic Evidence for Presentation of E{alpha}52-68 Structurally Related Self-Peptide(s) in I-E{alpha}-Deficient Mice
J. Immunol., May 1, 2000; 164(9): 4627 - 4634.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Ibnou-Zekri, M. Iwamoto, M. E. Gershwin, and S. Izui
Protection of Murine Lupus by the Ead Transgene Is MHC Haplotype-Dependent
J. Immunol., January 1, 2000; 164(1): 505 - 511.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
V. Brachet, G. Péhau-Arnaudet, C. Desaymard, G. Raposo, and S. Amigorena
Early Endosomes Are Required for Major Histocompatiblity Complex Class II Transport to Peptide-loading Compartments
Mol. Biol. Cell, September 1, 1999; 10(9): 2891 - 2904.
[Abstract] [Full Text]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. Madsen, N. Labrecque, J. Engberg, A. Dierich, A. Svejgaard, C. Benoist, D. Mathis, and L. Fugger
Mice lacking all conventional MHC class II genes
PNAS, August 31, 1999; 96(18): 10338 - 10343.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. S. Vacchio, J. Y. M. Lee, and J. D. Ashwell
Thymus-Derived Glucocorticoids Set the Thresholds for Thymocyte Selection by Inhibiting TCR-Mediated Thymocyte Activation
J. Immunol., August 1, 1999; 163(3): 1327 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Kenty and E. K. Bikoff
BALB/c Invariant Chain Mutant Mice Display Relatively Efficient Maturation of CD4+ T Cells in the Periphery and Secondary Proliferative Responses Elicited upon Peptide Challenge
J. Immunol., July 1, 1999; 163(1): 232 - 241.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Qadri, J. Thatte, C. G. Radu, B. Ober, and E. S. Ward
Characterization of the interaction of a TCR {alpha} chain variable domain with MHC II I-A molecules
Int. Immunol., June 1, 1999; 11(6): 967 - 977.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Nishimura, J. Washizu, Y. Naiki, T. Hara, Y. Fukui, T. Sasazuki, and Y. Yoshikai
MHC Class II-Dependent NK1.1+ {gamma}{delta} T Cells Are Induced in Mice by Salmonella Infection
J. Immunol., February 1, 1999; 162(3): 1573 - 1581.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
J. Antoine, T Lang, E Prina, N Courret, and R Hellio
H-2M molecules, like MHC class II molecules, are targeted to parasitophorous vacuoles of Leishmania-infected macrophages and internalized by amastigotes of L. amazonensis and L. mexicana
J. Cell Sci., January 8, 1999; 112(15): 2559 - 2570.
[Abstract] [PDF]

Home page
 J. Immunol.Home page
N. A. Wilson, P. Wolf, H. Ploegh, L. Ignatowicz, J. Kappler, and P. Marrack
Invariant Chain Can Bind MHC Class II at a Site Other Than the Peptide Binding Groove
J. Immunol., November 1, 1998; 161(9): 4777 - 4784.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. V. Chervonsky, R. M. Medzhitov, L. K. Denzin, A. K. Barlow, A. Yu. Rudensky, and C. A. Janeway Jr.
Subtle conformational changes induced in major histocompatibility complex class II molecules by binding peptides
PNAS, August 18, 1998; 95(17): 10094 - 10099.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. G. Radu, B. T. Ober, L. Colantonio, A. Qadri, and E. S. Ward
Expression and Characterization of Recombinant Soluble Peptide: I-A Complexes Associated with Murine Experimental Autoimmune Diseases
J. Immunol., June 15, 1998; 160(12): 5915 - 5921.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. K. Barlow, X. He, and C. Janeway Jr.
Exogenously Provided Peptides of a Self-antigen Can Be Processed into Forms that Are Recognized by Self-T Cells
J. Exp. Med., May 4, 1998; 187(9): 1403 - 1415.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. K. Bikoff, G. Kenty, and L. Van Kaer
Distinct Peptide Loading Pathways for MHC Class II Molecules Associated with Alternative Ii Chain Isoforms
J. Immunol., April 1, 1998; 160(7): 3101 - 3110.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Kenty, W. D. Martin, L. Van Kaer, and E. K. Bikoff
MHC Class II Expression in Double Mutant Mice Lacking Invariant Chain and DM Functions
J. Immunol., January 15, 1998; 160(2): 606 - 614.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. Pasare, V. Morafo, M. Entringer, P. Bansal, A. George, V. Bal, S. Rath, and J. M. Durdik
Presence of Activated Antigen-Binding B Cells During Immunization Enhances Relative Levels of IFN-{gamma} in T Cell Responses
J. Immunol., January 15, 1998; 160(2): 778 - 787.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
G. Raposo, D. Tenza, S. Mecheri, R. Peronet, C. Bonnerot, and C. Desaymard
Accumulation of Major Histocompatibility Complex Class II Molecules in Mast Cell Secretory Granules and Their Release upon Degranulation
Mol. Biol. Cell, December 1, 1997; 8(12): 2631 - 2645.
[Abstract] [Full Text]

Home page
 JCBHome page
V. Brachet, G. Raposo, S. Amigorena, and I. Mellman
Ii Chain Controls the Transport of Major Histocompatibility Complex Class II Molecules to and from Lysosomes
J. Cell Biol., April 7, 1997; 137(1): 51 - 65.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
S De Souza Leao, T Lang, E Prina, R Hellio, and J. Antoine
Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells
J. Cell Sci., January 10, 1995; 108(10): 3219 - 3231.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
T Lang, R Hellio, P. Kaye, and J. Antoine
Leishmania donovani-infected macrophages: characterization of the parasitophorous vacuole and potential role of this organelle in antigen presentation
J. Cell Sci., January 8, 1994; 107(8): 2137 - 2150.
[Abstract] [PDF]

Home page
 J. Cell Sci.Home page
T Lang, C de Chastellier, C Frehel, R Hellio, P Metezeau, S. Leao, and J. Antoine
Distribution of MHC class I and of MHC class II molecules in macrophages infected with Leishmania amazonensis
J. Cell Sci., January 1, 1994; 107(1): 69 - 82.
[Abstract] [PDF]

Home page
 ScienceHome page
F. Wells, S. Gahm, S. Hedrick, J. Bluestone, A Dent, and L. Matis
Requirement for positive selection of gamma delta receptor-bearing T cells
Science, August 23, 1991; 253(5022): 903 - 905.
[Abstract] [PDF]

Home page
 ScienceHome page
K. Rock, S Gamble, and L Rothstein
Presentation of exogenous antigen with class I major histocompatibility complex molecules
Science, August 24, 1990; 249(4971): 918 - 921.
[Abstract] [PDF]

Home page
 ScienceHome page
L. Matis, A. Fry, R. Cron, M. Cotterman, R. Dick, and J. Bluestone
Structure and specificity of a class II MHC alloreactive gamma delta T cell receptor heterodimer
Science, August 18, 1989; 245(4919): 746 - 749.
[Abstract] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
T. Sasazuki, T. Iwanaga, T. Inamitsu, Y. Yanagawa, M. Yasunami, A. Kimura, K. Hirokawa, and Y. Nishimura
Expression and Function of Human Major Histocompatibility Complex HLA-DQw6 Genes in the C57BL/6 Mouse
Cold Spring Harb Symp Quant Biol, January 1, 1989; 54(0): 513 - 520.
[Abstract] [PDF]

Home page
 ScienceHome page
M Hattori, J. Buse, R. Jackson, L Glimcher, M. Dorf, M Minami, S Makino, K Moriwaki, H Kuzuya, H Imura, et al.
The NOD mouse: recessive diabetogenic gene in the major histocompatibility complex
Science, February 14, 1986; 231(4739): 733 - 735.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Fukui, T. Oono, J.-P. Cabaniols, K. Nakao, K. Hirokawa, A. Inayoshi, T. Sanui, J. Kanellopoulos, E. Iwata, M. Noda, et al.
Diversity of T cell repertoire shaped by a single peptide ligand is critically affected by its amino acid residue at a T cell receptor contact
PNAS, December 5, 2000; 97(25): 13760 - 13765.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1984 by The American Association of Immunologists, Inc. All rights reserved.