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The Journal of Immunology, Vol 131, Issue 6 2781-2783, Copyright © 1983 by American Association of Immunologists

ARTICLES

Participation of auto-anti-idiotypes in immune complex glomerulonephritis in rabbits

M Zanetti and CB Wilson

We report the presence of auto-anti-Id antibodies in the glomerular immune deposits of a rabbit with chronic serum sickness induced by daily i.v. injections of bovine serum albumin. Auto-anti-Id antibodies were also documented in the serum of the same animal during the phase of chronic serum sickness in which immune complex glomerulonephritis develops. These results suggest that auto-anti-Id may normally participate in pathologic reactions and may be one of the mechanisms of potentiation and/or progression of immunopathologic lesions.




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