The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Maron, R.
Right arrow Articles by Cohen, I. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Maron, R.
Right arrow Articles by Cohen, I. R.

The Journal of Immunology, Vol 131, Issue 5 2316-2322, Copyright © 1983 by American Association of Immunologists

ARTICLES

T lymphocyte line specific for thyroglobulin produces or vaccinates against autoimmune thyroiditis in mice

R Maron, R Zerubavel, A Friedman and IR Cohen

We investigated Ly-1+ T lymphocyte line cells specifically reactive to thyroglobulin (Tg) that were isolated from mice primed with mouse Tg in adjuvant. Intravenous inoculation of as few as 10(5) line cells was sufficient to cause severe and prolonged thyroiditis in recipient mice that were intact, irradiated, or athymic nudes. Disease was independent of circulating Tg antibodies, suggesting that anti-Tg T lymphocytes could cause thyroiditis unaided by antibodies. Thyroiditogenic T lymphocytes could be isolated as cell lines from apparently healthy mice that had been immunized with non-thyroiditogenic bovine Tg in adjuvant, which indicates that autoimmune effector T lymphocytes may develop covertly in the course of immunization with foreign antigens. Finally, a single i.v. inoculation of anti-Tg T lymphocyte line cells attenuated by irradiation vaccinated mice completely against subsequent development of autoimmune thyroiditis produced either by active immunization to Tg or by passive transfer of intact line cells. Vaccinated mice that were protected from inflammatory lesions of thyroiditis still produced high titers of Tg antibodies in response to active immunization. Thus, vaccination specifically inhibited thyroiditogenic T lymphocytes but not helper T lymphocytes required for the production of Tg autoantibodies.


This article has been cited by other articles:


Home page
 EndocrinologyHome page
S. H. Wang, Z. Cao, J. M. Wolf, M. Van Antwerp, and J. R. Baker Jr.
Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis
Endocrinology, November 1, 2005; 146(11): 4721 - 4726.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
H. P. Ng, J. Paul Banga, and A. W. C. Kung
Development of a Murine Model of Autoimmune Thyroiditis Induced with Homologous Mouse Thyroid Peroxidase
Endocrinology, February 1, 2004; 145(2): 809 - 816.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Verginis, M. M. Stanford, and G. Carayanniotis
Delineation of Five Thyroglobulin T Cell Epitopes with Pathogenic Potential in Experimental Autoimmune Thyroiditis
J. Immunol., November 1, 2002; 169(9): 5332 - 5337.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
E. K. Akpek, S. H. Liu, and J. D. Gottsch
Induction of Experimental Autoimmune Keratitis by Adoptive Transfer of Human Corneal Antigen-Specific T-Cell Line
Invest. Ophthalmol. Vis. Sci., December 1, 2000; 41(13): 4182 - 4188.
[Abstract] [Full Text]

Home page
 IOVSHome page
C. Verhagen, F. Mor, J. B. A. Kipp, A. F. de Vos, R. van der Gaag, and I. R. Cohen
Experimental Autoimmune Keratitis Induced in Rats by Anti-Cornea T-cell Lines
Invest. Ophthalmol. Vis. Sci., September 1, 1999; 40(10): 2191 - 2198.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
D. Sun, J. N. Whitaker, and D. B. Wilson
Regulatory T cells in experimental allergic encephalomyelitis. I. Frequency and specificity analysis in normal and immune rats of a T cell subset that inhibits disease
Int. Immunol., March 1, 1999; 11(3): 307 - 315.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
F. Batteux, L. Tourneur, H. Trebeden, J. Charreire, and G. Chiocchia
Gene Therapy of Experimental Autoimmune Thyroiditis by In Vivo Administration of Plasmid DNA Coding for Fas Ligand
J. Immunol., January 1, 1999; 162(1): 603 - 608.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. A. M. Borghans, R. J. De Boer, E. Sercarz, and V. Kumar
T Cell Vaccination in Experimental Autoimmune Encephalomyelitis: A Mathematical Model
J. Immunol., August 1, 1998; 161(3): 1087 - 1093.
[Abstract] [Full Text] [PDF]

Home page
 LupusHome page
A. Ben-Yehuda, R. Bar-Tana, A. Livoff, N. Ron, I. Cohen, and Y. Naparstek
Lymph node cell vaccination against the lupus syndrome of MRL/lpr/lpr mice
Lupus, June 1, 1996; 5(3): 232 - 236.
[Abstract] [PDF]

Home page
 ScienceHome page
D Faustman and C Coe
Prevention of xenograft rejection by masking donor HLA class I antigens
Science, June 21, 1991; 252(5013): 1700 - 1702.
[Abstract] [PDF]

Home page
 ScienceHome page
A. Sinha, M. Lopez, and H. McDevitt
Autoimmune diseases: the failure of self tolerance
Science, June 15, 1990; 248(4961): 1380 - 1388.
[Abstract] [PDF]

Home page
 ScienceHome page
A. Lohse, F Mor, N Karin, and I. Cohen
Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells
Science, May 19, 1989; 244(4906): 820 - 822.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.