The JI PBL Intereron Source
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cheung, R. K.
Right arrow Articles by Gelfand, E. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cheung, R. K.
Right arrow Articles by Gelfand, E. W.

The Journal of Immunology, Vol 131, Issue 5 2291-2295, Copyright © 1983 by American Association of Immunologists

ARTICLES

Permissive role of calcium in the inhibition of T cell mitogenesis by calmodulin antagonists

RK Cheung, S Grinstein and EW Gelfand

The importance of Ca++ in the initiation of lymphocyte activation and mitogenesis has been supported by several studies. Because calmodulin functions as the intracellular mediator of the effects of Ca++, it likely plays a major role in the regulation of lymphocyte function. We have examined the effects of known calmodulin antagonists, the phenothiazines, on lectin-induced T cell mitogenesis and have shown a central role for Ca++ uptake in the expression of a phenothiazine- sensitive stage after lectin activation. The drug effects were observed only if the cells were previously activated by PHA or the ionophore A23187, and only in the presence of Ca++. These effects were restricted to a defined time period (5 hr) after lectin activation. The data support the concept that calmodulin is the target for the phenothiazine effects and demonstrate the permissive role of Ca++ in the mediation of these events.


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
R. Khanna, M. C. Chang, W. J. Joiner, L. K. Kaczmarek, and L. C. Schlichter
hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes. ROLES IN PROLIFERATION AND VOLUME REGULATION
J. Biol. Chem., May 21, 1999; 274(21): 14838 - 14849.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 1983 by The American Association of Immunologists, Inc. All rights reserved.