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The Journal of Immunology, Vol 131, Issue 3 1600-1603, Copyright © 1983 by American Association of Immunologists

ARTICLES

Immunotherapy of a murine B cell tumor with antibodies and F(ab')2 fragments against idiotypic determinants of its cell surface IgM

Y Perek, E Hurwitz, D Burowski and J Haimovich

Anti-idiotype antibodies against the IgM of the 38C-13 murine B lymphocyte cell line and F(ab')2 fragments derived from them were checked for their therapeutic effect against the killing of mice by 38C- 13 cells. Both intact molecules and the F(ab')2 fragments were effective in delaying or preventing the killing of mice by 38C-13 tumors when used in large amounts and by the appropriate routes.


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